Results 11 to 20 of about 378,605 (167)

HELIOS-expressing human CD8 T cells exhibit limited effector functions

Frontiers in Immunology, 2023
IntroductionThe transcription factor HELIOS is primarily known for its expression in CD4 regulatory T cells, both in humans and mice. In mice, HELIOS is found in exhausted CD8 T cells.
Damien Neyens, Thibault Hirsch, Achraqat Abdel Aziz Issa Abdel Hadi, Nicolas Dauguet, Christophe Vanhaver, Alexandre Bayard, Claude Wildmann, Mathieu Luyckx, Mathieu Luyckx, Jean-Luc Squifflet, Jean-Luc Squifflet, Quentin D’Hondt, Céline Duhamel, Antoine Huaux, Virginie Montiel, Mélanie Dechamps, Pierre van der Bruggen, Pierre van der Bruggen   +17 more
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Circulating activated immune cells as a potential blood biomarkers of non-small cell lung cancer occurrence and progression

BMC Pulmonary Medicine, 2021
Background Treatment for non-small cell lung cancer (NSCLC) has greatly improved in recent years. However, noninvasive early screening for carcinogenesis and progression unclear.
Yingyi Wang, Na Zhou, Rui Zhu, Xiaoyuan Li, Zhao Sun, Yang Gao, Wei Liu, Changting Meng, Yuping Ge, Chunmei Bai, Taisheng Li, Hongsheng Liu   +11 more
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Defining Memory CD8 T Cell [PDF]

Frontiers in Immunology, 2018
CD8 T cells comprising the memory pool display considerable heterogeneity, with individual cells differing in phenotype and function. This review will focus on our current understanding of heterogeneity within the antigen-specific memory CD8 T cell compartment and classifications of memory CD8 T cell subsets with defined and discrete functionalities ...
Matthew D. Martin, Vladimir P. Badovinac, Vladimir P. Badovinac, Vladimir P. Badovinac   +3 more
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Skewed distribution of IL-7 receptor-α-expressing effector memory CD8+ T cells with distinct functional characteristics in oral squamous cell carcinoma.

PLoS ONE, 2014
CD8(+) T cells play important roles in anti-tumor immunity but distribution profile or functional characteristics of effector memory subsets during tumor progression are unclear.
Jang-Jaer Lee, Chiou-Yueh Yeh, Chiau-Jing Jung, Ching-Wen Chen, Mao-Kuang Du, Hui-Ming Yu, Chia-Ju Yang, Hui-Yi Lin, Andy Sun, Jenq-Yuh Ko, Shih Jung Cheng, Yen-Liang Chang, Jean-San Chia   +12 more
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Circulating activated lymphocyte subsets as potential blood biomarkers of cancer progression

Cancer Medicine, 2020
The objective of this study was to predict the value of lymphocyte subsets in cancer progression. Peripheral blood was obtained from 327 untreated patients with cancer and 158 healthy volunteers.
Ying‐Yi Wang, Na Zhou, Hong‐sheng Liu, Xiao‐Lei Gong, Rui Zhu, Xiao‐Yuan Li, Zhao Sun, Xu‐Hong Zong, Ning‐Ning Li, Chang‐Ting Meng, Chun‐Mei Bai, Tai‐Sheng Li   +11 more
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Understanding memory CD8 + T cells [PDF]

Immunology Letters, 2017
Memory CD8+ T cells were originally thought to exist as two populations (effector and central memory). In recent years, a third population called resident memory T cells has been discovered and further to this these populations are being divided into different subtypes. Understanding the function and developmental pathways of memory CD8+ T cells is key
Tasleem, Samji, Kamal M, Khanna
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The Timing of Stimulation and IL-2 Signaling Regulate Secondary CD8 T Cell Responses. [PDF]

PLoS Pathogens, 2015
Memory CD8 T cells provide protection to immune hosts by eliminating pathogen-infected cells during re-infection. While parameters influencing the generation of primary (1°) CD8 T cells are well established, the factors controlling the development of ...
Shaniya H Khan, Matthew D Martin, Gabriel R Starbeck-Miller, Hai-Hui Xue, John T Harty, Vladimir P Badovinac   +5 more
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Intratumoral CXCL13+CD8+T cell infiltration determines poor clinical outcomes and immunoevasive contexture in patients with clear cell renal cell carcinoma

Journal for ImmunoTherapy of Cancer, 2021
Background Chemokine (C-X-C motif) ligand 13 (CXCL13) was known as a selective chemotaxis for B cells, a product of follicular helper CD4+T cells (TFH) and a contributor to tertiary lymphoid structures (TLS).
Jiejie Xu, Yu Xia, Ying Xiong, Yu Zhu, Zewei Wang, Han Zeng, Zhaopei Liu, Jiajun Wang, Yuan Chang, Le Xu, Qi Bai, Jianming Guo, Siyuan Dai, Kaifeng Jin, Wenbin Jiang, Zhiyuan Lin, Yang Qu   +16 more
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CD4 T Cell-Dependent CD8 T Cell Maturation [PDF]

The Journal of Immunology, 2004
Abstract We have investigated the contribution of CD4 T cells to the optimal priming of functionally robust memory CD8 T cell subsets. Intranasal infection of CD4 T cell-deficient (CD4−/−) mice with lymphocytic choriomeningitis virus resulted in the elaboration of virus-specific CD8 T cell responses that cleared the infection.
Aaruni, Khanolkar, Michael J, Fuller, Allan J, Zajac   +2 more
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Prognostic values of tissue-resident CD8+T cells in human hepatocellular carcinoma and intrahepatic cholangiocarcinoma

World Journal of Surgical Oncology, 2023
Background Tissue-resident CD8+T cells (CD103+CD8+T cells) are the essential effector cell population of anti-tumor immune response in tissue regional immunity. And we have reported that IL-33 can promote the proliferation and effector function of tissue-
Lujun Chen, Hao Huang, Ziyi Huang, Junjun Chen, Yingting Liu, Yue Wu, An Li, Junwei Ge, Zhang Fang, Bin Xu, Xiao Zheng, Changping Wu   +11 more
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