CNS Macrophages Control Neurovascular Development via CD95L [PDF]
Cell Reports, 2017 The development of neurons and vessels shares striking anatomical and molecular features, and it is presumably orchestrated by an overlapping repertoire of extracellular signals.
Si Chen +11 more
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Therapeutic approaches targeting CD95L/CD95 signaling in cancer and autoimmune diseases
Cell Death and Disease, 2022 Cell death plays a pivotal role in the maintenance of tissue homeostasis. Key players in the controlled induction of cell death are the Death Receptors (DR).
Vesna Risso +2 more
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CD95L and Anti-Tumor Immune Response: Current Understanding and New Evidence
Cancer Management and Research, 2021 David M Richards, Christian Merz, Christian Gieffers, Andriy Krendyukov Apogenix AG, Heidelberg, GermanyCorrespondence: Andriy Krendyukov Tel +49 6221 5860877Email andriy.krendyukov@apogenix.comAbstract: The ability of FasL/CD95L to induce apoptosis in ...
Richards DM +3 more
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Cell Apoptosis and Glucocorticoid‐Induced Osteonecrosis
Med ResearchGlucocorticoids (GCs) are steroid hormones commonly used to treat inflammation, autoimmune diseases, and malignant tumors. By inhibiting bone formation and promoting osteoclast apoptosis, GCs significantly accelerate the onset of femoral head ...
Xiumei Tang +7 more
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A Novel Tetravalent CD95/Fas Fusion Protein With Superior CD95L/FasL Antagonism. [PDF]
ProteinsABSTRACT Inhibition of CD95/Fas activation is currently under clinical investigation as a therapy for glioblastoma multiforme and preclinical studies suggest that disruption of the CD95–CD95L interaction could also be a strategy to treat inflammatory and neurodegenerative disorders.
Lang I, Paulus O, Zaitseva O, Wajant H.
europepmc +2 more sources
Pre-existing CD95-based Temra immunity in patients with recurrent/metastatic nasopharyngeal carcinoma predicts response and hyperprogression to dual PD-L1 and TGFβ inhibition. [PDF]
Clin Transl Med• Lower baseline CD95⁺ Temra levels were associated with treatment response and longer survival. • Higher CD57⁺ Temra frequencies predicted improved overall survival, independent of response. • Post‐treatment shifts in CD95/CD57 expression correlated with survival outcomes.
Kam NW +8 more
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The CD95/CD95L signaling pathway: A role in carcinogenesis [PDF]
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 2014 Apoptosis is a fundamental process that contributes to tissue homeostasis, immune responses, and development. The receptor CD95, also called Fas, is a member of the tumor necrosis factor receptor (TNF-R) superfamily. Its cognate ligand, CD95L, is implicated in immune homeostasis and immune surveillance, and various lineages of malignant cells exhibit ...
Fouqué, Amélie +2 more
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The naturally processed CD95L elicits a c-yes/calcium/PI3K-driven cell migration pathway. [PDF]
PLoS Biology, 2011 Patients affected by chronic inflammatory disorders display high amounts of soluble CD95L. This homotrimeric ligand arises from the cleavage by metalloproteases of its membrane-bound counterpart, a strong apoptotic inducer.
Sébastien Tauzin +13 more
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African Journal of Laboratory Medicine, 2021 Background: Chronic viral hepatitis B (HBV) is characterised by progressive hepatocyte destruction and T-cell depletion. The mechanisms of the CD95-CD95 ligand (CD95L) signalling pathway during this chronic disease and the cirrhotic process remains ...
Franklin S. Azebaze Agueguia +8 more
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Decoy Receptors in Autoimmunity: Molecular Guardians and Pathogenic Players in Immune Dysregulation. [PDF]
Mediators InflammAutoimmune disorders encompass a varied range of diseases in which the immune system mistakenly targets and attacks the body’s own tissues. The causes of the conditions are unknown. It is presumed that various genetic, environmental, and immune factors all play a part.
Farahani H +4 more
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