Results 41 to 50 of about 6,938 (195)

Markers of apoptosis in patients with type 1 diabetes mellitus at the onset of the disease

Сахарный диабет, 2009
Aim. This work was to study activation markers of apoptosis (CD95, CD95L) on peripheral blood lymphocytes of patients with type 1 diabetes mellitus (DM1) at the onset of the disease. Materials and methods.
Elena Vladimirovna Pekareva, Tatiana Vasil'evna Nikonova, Vera Anatol'evna Gorelysheva, Yana Stanislavovna Zvereva, Svetlana Mikhailovna Stepanova, Sergey Alexandrovich Prokof'ev, Olga Mikhailovna Smirnova   +6 more
doaj   +1 more source

B Cell apoptosis in the central nervous system in experimental autoimmune Encephalomyelitis: Roles of B Cell CD95, CD95L and Bcl-2 expression [PDF]

, 2000
The role and fate of B cells in the central nervous system (CNS) in experimental autoimmune encephalomyelitis (EAE) are unknown. Using enzyme-linked immunospot assays we now show that B cells reactive to myelin basic protein (MBP) accumulate in the CNS ...
Catherine A White, Czerkinsky, Deibler, Eugster, Garrone, Gausas, Hahne, Hartley, Hjelmström, Hsu, Ishigami, Kim B Nguyen, La Pushin, Lens, MacPhee, McCombe, McCombe, Michael P Pender, Myers, Nguyen, Nguyen, Nguyen, Nguyen, Parry, Pender, Pender, Pender, Peter, Rathmell, Rothstein, Russell, Scaffidi, Schmied, Sedgwick, Sriram, Tabi, Tsubata, Tsubata, Valentine, Varndell, Wang, White, White, Willenborg, Wolf, Woollett   +45 more
core   +1 more source

Bacteroides acidifaciens in the gut plays a protective role against CD95-mediated liver injury

Gut Microbes, 2022
The intestinal flora plays an important role in the development of many human and animal diseases. Microbiome association studies revealed the potential regulatory function of intestinal bacteria in many liver diseases, such as autoimmune hepatitis ...
Hesuiyuan Wang, Qing Wang, Chengmao Yang, Mingming Guo, Xiaoyue Cui, Zhe Jing, Yujie Liu, Wanjin Qiao, Hang Qi, Hongyang Zhang, Xu Zhang, Na Zhao, Mengjuan Zhang, Min Chen, Song Zhang, Haijin Xu, Liqing Zhao, Mingqiang Qiao, Zhenzhou Wu   +18 more
doaj   +1 more source

Analysis of knockout/knockin mice that express a mutant FasL lacking the intracellular domain [PDF]

, 2009
Fas ligand (FasL; CD178; CD95L) is a type II transmembrane protein belonging to the tumour necrosis factor family; its binding to the Fas receptor (CD95; APO-1) triggers apoptosis in the receptor-bearing cell.
Kirkin, Vladimir, Lückerath, Katharina Maria, Zörnig, Martin   +2 more
core   +1 more source

CD95 ligand (CD95L) immunohistochemistry: a critical study on 12 antibodies [PDF]

Cell Death & Differentiation, 2001
In recent years, some studies on the expression of CD95(Fas/APO-1) ligand (CD95L) in tissues or cells raised concerns about the specificity of the antibodies used. We therefore tested 12 CD95L antibodies for their reliability in immunocyto/histochemistry by (i) staining CD95L-transfected and control CV-1/EBNA cells and (ii) comparing staining patterns ...
J, Sträter, H, Walczak, C, Hasel, I, Melzner, F, Leithäuser, P, Möller   +5 more
openaire   +2 more sources

Immunogenetic characteristics of LADA

Сахарный диабет, 2011
Latent autoimmune diabetes of adults (LADA) is a variant of autoimmune diabetes mellitus. Its clinical feature not typical for classical DM1 despitethe presence of positive autoantibodies is characterized by the low rate of autoimmune destruction that ...
Tatiana Vasil'evna Nikonova, Pavel Vasil'evich Apanovich, Elena Vladimirovna Pekareva, Vera Anatol'evna Gorelysheva, Svetlana Mikhailovna Stepanova, Yulia Vladimirovna Tishina, Sergey Alexandrovich Prokof'ev, Alexander Vasil'evich Karpukhin   +7 more
doaj   +1 more source

Activation-Induced Apoptosis of Autoreactive and Alloreactive T Lymphocytes in the Target Organ as a Major Mechanism of Tolerance [PDF]

, 1999
Normal individuals have mature T lymphocytes that are capable of reacting to self-antigens and can be activated by cross-reacting environmental antigens. The mechanism that maintains immune tolerance and prevents these activated autoreactive T cells from
Ahmed, Alderson, Allison, Ashkenazi, Barac-Latas, Bauer, Bellgrau, Bertolino, Bertolino, Bishop, Boise, Brunner, Charriaut-Marlangue, Collette, Collette, Deng, Dhein, Dowling, Firestein, Ford, Gold, Grasl-Kraupp, Griffith, Groux, Hickey, Ishigami, Itoh, Ju, Kohji, Kong, Kurts, Lee, Lenardo, Levine, Levine, Li, Liu, Lou, Luo, MacPhee, Martin, Mason, Matsumoto, Matsumoto, Matzinger, McCombe, McCombe, Michael P Pender, Mueller, Nakajima, Nguyen, Nguyen, Nuti, Ohmori, Ozawa, Pender, Pender, Pender, Pender, Pender, Qian, Refaeli, Russell, Scaffidi, Schmied, Schweitzer, Smith, Smith, Strasser, Sun, Tabi, Tabi, Van Parijs, Weishaupt, Wekerle, White, White, Willenborg, Yang, Zacharchuk, Zettl, Zettl, Zettl   +82 more
core   +1 more source

CD95/Fas, Non-Apoptotic Signaling Pathways, and Kinases

Frontiers in Immunology, 2017
Endothelial cells lining new blood vessels that develop during inflammatory disorders or cancers act as doors that either allow or block access to the tumor or inflamed organ.
Matthieu Le Gallo, Matthieu Le Gallo, Matthieu Le Gallo, Amanda Poissonnier, Amanda Poissonnier, Amanda Poissonnier, Patrick Blanco, Patrick Blanco, Patrick Legembre, Patrick Legembre, Patrick Legembre   +10 more
doaj   +1 more source

Activation of CD95L fusion protein prodrugs by tumor-associated proteases [PDF]

Cell Death & Differentiation, 2006
To achieve tumor cell-restricted activation of CD95, we developed a CD95L fusion protein format, in which CD95L activity is only unmasked upon antibody-mediated binding to tumor cells and subsequent processing by tumor-associated proteases, such as matrix metalloproteases (MMPs) and urokinase plasminogen activator (uPA).
Watermann, Iris, Gerspach, Jeanette, Lehne, M., Seufert, Jochen, Schneider, Britta, Pfizenmaier, Klaus, Wajant, Harald   +6 more
openaire   +3 more sources

CD95L pro-drug: a novel Swiss Army Knife in cancer therapy? [PDF]

Cell Death & Differentiation, 2006
In the search for the 'magic bullet' to fight cancer, scientists have developed a plethora of more or less useful drugs and treatments. Nonetheless, the current success rate of various antitumor chemotherapeutics and biologics for the noninvasive treatment is still quite disappointing.
Kassahn, Daniela, Nachbur, Ueli, Brunner, Thomas   +2 more
openaire   +3 more sources