Results 51 to 60 of about 6,938 (195)

CD95 Structure, Aggregation and Cell Signaling

Frontiers in Cell and Developmental Biology, 2020
CD95 is a pre-ligand-associated transmembrane (TM) receptor. The interaction with its ligand CD95L brings to a next level its aggregation and triggers different signaling pathways, leading to cell motility, differentiation or cell death.
Nicolas Levoin, Mickael Jean, Patrick Legembre   +2 more
doaj   +1 more source

CD95/Fas suppresses NF-κB activation through recruitment of KPC2 in a CD95L/FasL-independent mechanism

iScience, 2021
Summary: CD95 expression is preserved in triple-negative breast cancers (TNBCs), and CD95 loss in these cells triggers the induction of a pro-inflammatory program, promoting the recruitment of cytotoxic NK cells impairing tumor growth.
Jean-Philippe Guégan, Justine Pollet, Christophe Ginestier, Emmanuelle Charafe-Jauffret, Marcus E. Peter, Patrick Legembre   +5 more
doaj   +1 more source

P16-20. TB co-infection is associated with increased cytotoxic phenotype marker expression on CD8+ T lymphocytes, but reduced HIV-specific degranulation [PDF]

, 2009
Please help us populate SUNScholar with the post print version of this article.
Glashoff RH, Kabue J, de Swardt D, Pillay ST   +3 more
core   +2 more sources

Correction: The Naturally Processed CD95L Elicits a c-Yes/Calcium/PI3K-Driven Cell Migration Pathway. [PDF]

PLoS Biology, 2019
[This corrects the article DOI: 10.1371/journal.pbio.1001090.].
Sébastien Tauzin, Benjamin Chaigne-Delalande, Eric Selva, Nadine Khadra, Sophie Daburon, Cécile Contin-Bordes, Patrick Blanco, Jacques Le Seyec, Thomas Ducret, Laurent Counillon, Jean-François Moreau, Paul Hofman, Pierre Vacher, Patrick Legembre   +13 more
doaj   +1 more source

Many si/shRNAs can kill cancer cells by targeting multiple survival genes through an off-target mechanism

eLife, 2017
Over 80% of multiple-tested siRNAs and shRNAs targeting CD95 or CD95 ligand (CD95L) induce a form of cell death characterized by simultaneous activation of multiple cell death pathways preferentially killing transformed and cancer stem cells. We now show
William Putzbach, Quan Q Gao, Monal Patel, Stijn van Dongen, Ashley Haluck-Kangas, Aishe A Sarshad, Elizabeth T Bartom, Kwang-Youn A Kim, Denise M Scholtens, Markus Hafner, Jonathan C Zhao, Andrea E Murmann, Marcus E Peter   +12 more
doaj   +1 more source

Involvement of raft aggregates enriched in Fas/CD95 death-inducing signaling complex in the antileukemic action of edelfosine in Jurkat cells [PDF]

, 2012
[Background]: Recent evidence suggests that co-clustering of Fas/CD95 death receptor and lipid rafts plays a major role in death receptor-mediated apoptosis.
Gajate, Consuelo, González-Camacho, Fernando, Mollinedo, Faustino   +2 more
core   +2 more sources

Non‐Coding RNAs in Breast Cancer Radioresistance: Mechanisms, Functional Roles and Translational Potentials

Cell Proliferation, Volume 59, Issue 2, February 2026.
Non‐coding RNAs (ncRNAs) regulate breast cancer radioresistance via cell cycle, DNA repair and tumour microenvironment pathways. Targeting ncRNAs (e.g., HOTAIR and miR‐155) with RNA‐based therapies (ASOs and CRISPR) shows promise but faces delivery challenges.
Xiaohui Zhao, Yuting Qiu, Jie Chen, Danni Wang, Zairui Wang, Shuang Ma, Yimin Liu, Guoying Liu, Zhuofei Bi   +8 more
wiley   +1 more source

Reactome knowledgebase of human biological pathways and processes [PDF]

, 2009
Reactome (http://www.reactome.org) is an expert-authored, peer-reviewed knowledgebase of human reactions and pathways that functions as a data mining resource and electronic textbook.
Birney, E., Caudy, M., Croft, D., D'Eustachio, P., de Bono, B., Garapati, P., Gillespie, M., Gopinath, G., Hemish, J., Hermjakob, H., Jassal, B., Kanapin, A., Lewis, S., Mahajan, S., Matthews, L., May, B., Schmidt, E., Stein, L. D., Vastrik, I., Wu, G.   +19 more
core   +3 more sources

Nitric Oxide Synthase Type III Overexpression By Gene Therapy Exerts Antitumoral Activity In Mouse Hepatocellular Carcinoma

Redox Biology, 2015
Hepatocellular carcinoma develops in cirrhotic liver. The nitric oxide (NO) synthase type III (NOS-3) overexpression induces cell death in hepatoma cells.
Raúl González, Ángel J. De la Rosa, Santiago Romero-Brufau, Lydia Barrera-Pulido, Francisco Gallardo-Chamizo, Sheila Pereira, Luís M. Marín, José M. Álamo, Ángeles Rodríguez-Hernández, Francisco J. Padillo, Jordi Muntané   +10 more
doaj   +1 more source

Death Induced by CD95 or CD95 Ligand Elimination

Cell Reports, 2014
CD95 (Fas/APO-1), when bound by its cognate ligand CD95L, induces cells to die by apoptosis. We now show that elimination of CD95 or CD95L results in a form of cell death that is independent of caspase-8, RIPK1/MLKL, and p53, is not inhibited by Bcl-xL ...
Abbas Hadji, Paolo Ceppi, Andrea E. Murmann, Sonia Brockway, Abhinandan Pattanayak, Bhavneet Bhinder, Annika Hau, Shirley De Chant, Vamsi Parimi, Piotre Kolesza, JoAnne Richards, Navdeep Chandel, Hakim Djaballah, Marcus E. Peter   +13 more
doaj   +1 more source