Results 61 to 70 of about 6,938 (195)
BMC Immunology, 2023 Background Patients with Sjögren’s syndrome, like other patients with autoimmune disorders, display dysregulation in the function of their immune system. Fas and Fas Ligand (FasL) are among the dysregulated proteins. Methods We studied Fas and FasL on IL-
Irena Lindrova +9 more
doaj +1 more source
Modulation of host cell pathways by Coxiella burnetii Dot/Icm effectors
mLife, Volume 4, Issue 6, Page 577-596, December 2025.Abstract Coxiella burnetii, the etiological agent of Q fever, is a significant intracellular bacterial pathogen. C. burnetii is a highly infectious pathogen that primarily targets pulmonary alveolar macrophages during natural infection. It can then disseminate to macrophages in other tissues and organs, leading to chronic infections. C.
Jingya Yuan +3 more
wiley +1 more source
The Scientific World Journal, 2013 Up- and downregulation of eosinopoiesis control pulmonary eosinophilia in human asthma. In mice, eosinopoiesis is suppressed in vitro by prostaglandin E2 (PGE2) and in vivo by diethylcarbamazine, through a proapoptotic mechanism sequentially requiring ...
Bianca de Luca +9 more
doaj +1 more source
eLife, 2016 Integrin activation is crucial for the regulation of leukocyte rolling, adhesion and trans-vessel migration during inflammation and occurs by engagement of myeloid cells through factors presented by inflamed vessels.
Liang Gao +5 more
doaj +1 more source
Death receptor-based enrichment of Cas9-expressing cells [PDF]
, 2016 Background: The CRISPR/Cas9 genome editing system has greatly facilitated and expanded our capacity to engineer mammalian genomes, including targeted gene knock-outs. However, the phenotyping of the knock-out effect requires a high DNA editing efficiency.
Aschenbrenner, S. +6 more
core +1 more source
CD95L-Blockade als therapeutisches Target beim Pankreaskarzinom
, 2012 129.
Goumas, FA +6 more
openaire +2 more sources
Effect of reactive oxygen species generation in rabbit corneal epithelial cells on inflammatory and apoptotic signaling pathways in the presence of high osmotic pressure. [PDF]
PLoS ONE, 2013 It is generally accepted that high osmotic pressure (HOP) of lacrimal fluid is the core mechanism causing ocular inflammation and injury. However, the association between HOP and the regulation of cell inflammatory response and apoptotic pathways remains
Yihui Chen +5 more
doaj +1 more source
CD73 Expression by CD4 + T Cells Marks Early Effector Memory T Cells
Immunology, Volume 176, Issue 4, Page 454-467, December 2025.The role of CD73 in the development of naïve CD4+ T cells. Naïve CD4+ T cells, which are negative for CD25, CD44, and positive for CD62L, are depicted based on the expression of CD73. CD73− and CD73+ subpopulations among naïve CD4+ T cells bear distinct characteristics.
Luxia Chen +5 more
wiley +1 more source
Pro- and anti-apoptotic CD95 signaling in T cells
Cell Communication and Signaling, 2011 The TNF receptor superfamily member CD95 (Fas, APO-1, TNFRSF6) is known as the prototypic death receptor in and outside the immune system. In fact, many mechanisms involved in apoptotic signaling cascades were solved by addressing consequences and ...
Janssen Ottmar, Paulsen Maren
doaj +1 more source
Monocytes in Neonatal Bacterial Sepsis: Think Tank or Workhorse?
BioChem, 2022 Infection and sepsis remain among the leading causes of neonatal mortality. The susceptibility of newborns to infection can be attributed to their immature immune system.
Caitlin Doughty +5 more
doaj +1 more source