Results 71 to 80 of about 6,938 (195)

Weight Loss‐Associated Remodeling of Adipose Tissue Immunometabolism

Obesity Reviews, Volume 26, Issue 12, December 2025.
ABSTRACT Obesity is a multifactorial condition characterized by excessive adiposity and systemic chronic low‐grade inflammation. Recent literature reflects a growing appreciation for the complex interplay between metabolism and the immune system in the pathogenesis of obesity‐related health conditions.
Paulo José Basso, Alejandro Schcolnik‐Cabrera, Mengyi Zhu, Erin Strachan, Xavier Clemente‐Casares, Sue Tsai   +5 more
wiley   +1 more source

Gene expression profiling of the anti-glioma effect of Cilengitide [PDF]

, 2013
Cilengitide (EMD121974), an inhibitor of the adhesive function of integrins, demonstrated preclinical efficacy against malignant glioma. It is speculated that cilengitide can inhibit tumor growth, invasion, and angiogenesis.
Chiocca, E Antonio, Date, Isao, Fujii, Kentaro, Ichikawa, Tomotsugu, Ishida, Joji, Kaur, Balveen, Kurozumi, Kazuhiko, Michiue, Hiroyuki, Onishi, Manabu, Shimazu, Yosuke   +9 more
core   +1 more source

Reirradiation: Standards, challenges, and patient‐focused strategies across tumor types

CA: A Cancer Journal for Clinicians, Volume 75, Issue 6, Page 630-666, November/December 2025.
Abstract Reirradiation (reRT), defined as administering a course of radiation therapy to a specific area previously irradiated, is an evolving treatment strategy for locoregionally recurrent cancer that offers significant potential and poses inherent challenges.
Arnaud Beddok, Jonas Willmann, Anna Embring, Ane L. Appelt, Panagiotis Balermpas, Kevin Chua, J. Isabelle Choi, Bernice Simone Elger, Dorota Gabrys, Peter Hoskin, Maximilian Niyazi, David Pasquier, Kelly Paradis, Orit Kaidar‐Person, Corien Plaisier, Nicole C. Schmitt, Conor E. Steuer, Juliette Thariat, Sue S. Yom, Philip Poortmans, Eliana Vasquez Osorio, Nicolaus Andratschke   +21 more
wiley   +1 more source

Self‐Assembling Multi‐Antigen T Cell Hybridizers for Precision Immunotherapy of Multiple Myeloma

Advanced Healthcare Materials, Volume 14, Issue 29, November 14, 2025.
A novel modular T‐cell engager platform, MATCH, is developed for personalized multiple myeloma therapy. MATCH uses complementary oligonucleotide‐linked Fab’ fragments to enable flexible targeting of MM antigens and controlled T‐cell activation. The system shows potent, antigen‐specific cytotoxicity in vitro and in vivo, highlighting its potential for ...
Shannuo Li, Jiahui Li, Hasan Al Faruque, Paul Shami, Birgit Knoechel, Jens Lohr, Douglas Sborov, Jiyuan Yang, Jindřich Kopeček   +8 more
wiley   +1 more source

Fas Ligand (CD95L) Protects Neurons Against Perforin- Mediated T Lymphocyte Cytotoxicity [PDF]

The Journal of Immunology, 2001
Abstract Previous work showed that neurons of the CNS are protected against perforin-mediated T cell cytotoxicity, but are susceptible to Fas-mediated apoptosis. In this study, we report that Fas ligand (FasL) expression by neurons is involved in protection against perforin-mediated T cell cytotoxicity.
I, Medana, Z, Li, A, Flügel, J, Tschopp, H, Wekerle, H, Neumann   +5 more
openaire   +2 more sources

CSIG-22. Cd95l/Cd95 GENE DELETION DECREASES MOUSE GLIOMA TUMORIGENESIS THROUGH THE INHIBITION OF NON-CANONICAL CD95L/CD95-MEDIATED CELL GROWTH AND IMMUNOSUPPRESSION

Neuro-Oncology, 2021
Abstract CD95 is a transmembrane receptor with potential to promote both cell death and growth. Initially described to trigger apoptosis upon ligand (CD95L) engagement, CD95 may also prompt cell proliferation, invasion and stemness. CD95 stimulation to induce cancer cell apoptosis has been proved clinically impracticable.
Clara Quijano-Rubio, Michael Weller
openaire   +1 more source

Cytofluorymetryczna analiza wybranych markerów apoptozy Fas/FasL (CD95/CD95L) w tkance gruczołu tarczowego u młodocianych pacjentów z chorobą Gravesa-Basedowa oraz zapaleniem tarczycy typu Hashimoto [PDF]

Pediatric Endocrinology, Diabetes and Metabolism, 2006
Wprowadzenie: Apoptoza, to jedna z postaci programowanej śmierci komórek, nazwana także śmiercią fizjologiczną albo śmiercią samobójczą komórek – jest mechanizmem regulacyjnym, pozwalającym na usunięcie komórek wytworzonych w nadmiarze i ...
Artur Bossowski, Anna Stasiak-Barmuta, Barbara Czarnocka, Mirosława Urban, Anna Łyczkowska, Marek Niedziela, Krzysztof Bardadin, Jolanta Czerwińska, Jacek Dadan, Marek Baltaziak   +9 more
doaj  

Dendritic cell-elicited B-cell activation fosters immune privilege via IL-10 signals in hepatocellular carcinoma

Nature Communications, 2016
Activation and biological function of B cells in cancer are still unclear. Here, the authors show that hepatocarcinoma cells drive the formation of semimature dendritic cells that in turn activate FcγRIIlow/−tumour B cells through the CD95L/CD95 axis ...
Fang-Zhu Ouyang, Rui-Qi Wu, Yuan Wei, Rui-Xian Liu, Dong Yang, Xiao Xiao, Limin Zheng, Bo Li, Xiang-Ming Lao, Dong-Ming Kuang   +9 more
doaj   +1 more source

ACSS2/AATF Drives Soluble FasL‐Mediated CD8+ T Cell Apoptosis in Pancreatic Neuroendocrine Tumors

Advanced Science, Volume 12, Issue 40, October 27, 2025.
This study unveils that ACSS2‐driven acetate metabolism fuels histone pan‐acetylation in pancreatic neuroendocrine tumors (PNETs), remodeling the epigenetic landscape. The ACSS2/AATF axis transcriptionally activates soluble FasL (sFasL), which engages Fas receptors on infiltrating CD8+ T cells to trigger caspase‐8/3‐mediated apoptosis.
Qin Dang, Ting Wang, Yan Wang, Zeng Ye, Borui Li, Xuan Pan, Zheng Li, Guixiong Fan, Desheng Jing, Junfeng Xu, Qiangsheng Hu, Shunrong Ji, Xiaowu Xu, Xianjun Yu, Yi Qin   +14 more
wiley   +1 more source

Phenotypic and functional characterization of T cells in white matter lesions of multiple sclerosis patients [PDF]

, 2017
T cells are considered pivotal in the pathology of multiple sclerosis (MS), but their function and antigen specificity are unknown. To unravel the role of T cells in MS pathology, we performed a comprehensive analysis on T cells recovered from paired ...
Hintzen, R.Q. (Rogier), Janssen, M. (Malou), Langerak, A.W. (Anton), Luijn, M.M. (Marvin) van, Melief, M.J. (Marie-José), Michels, S.S. (Samira S.), Nierop, G.P. (Gijs) van, Ouwendijk, W.J.D. (Werner), Verjans, G.M.G.M. (George)   +8 more
core   +1 more source