Results 81 to 90 of about 6,938 (195)

Advancements in DNA‐Driven Precision Modulation of Cell Surface Receptor for Programmable Cellular Functions

Advanced Science, Volume 12, Issue 32, August 28, 2025.
DNA‐Based Genetic and Non‐Genetic Tools for Receptor Engineering. This review highlights recent advances in DNA‐based strategies for receptor engineering, including genetic approaches like domain fusion and site‐directed mutagenesis, as well as non‐genetic methods using functional nucleic acids, DNA nanostructures, and dynamic DNA reactions.
Hexin Nan, Ming Cai, Yiyu Wang, Hong‐Hui Wang, Zhou Nie   +4 more
wiley   +1 more source

Asunercept as an innovative therapeutic approach for recurrent glioblastoma and other malignancies

Cancer Management and Research, 2019
Andriy Krendyukov, Christian GieffersApogenix AG, Heidelberg, GermanyCorrespondence: Andriy KrendyukovApogenix AG, Im Neuenheimer Feld 584, Heidelberg 69120, GermanyEmail andriy.krendyukov@apogenix.comAbstract: Glioblastoma is the most common and ...
Krendyukov A, Gieffers C
doaj  

Isolation and cultivation of adult primary bovine hepatocytes from abattoir derived liver [PDF]

, 2016
The aim was to establish a cell culture of adult primary bovine hepatocytes obtained from liver following slaughter and to cultivate the cells in a sandwich culture. Cells and medium samples were taken after separation of cells (day 0), during monolayer (
Ehrhardt, Sonja, Schmicke, Marion
core   +1 more source

Sjogren’s syndrome: apoptosis by anti-SSA and anti-SSB antibodies

Reumatismo, 2011
The pathogenesis of the Sjogren’s Syndrome (SjS) has not yet been completely defined. However, the cell-mediated immunity plays an important role and the apoptosis of the ductal and acinar epithelial cells is responsible of the glandular tissue damage ...
A. Scagliusi, S. D'Amore, M. D'Amore, P. Scagliusi   +3 more
doaj   +1 more source

Effects of DNA Origami‐Based Nanoagent Design on Apoptosis Induction in a Large 3D Cancer Spheroid Model

Small, Volume 21, Issue 24, June 19, 2025.
The ability of DNA origami to penetrate through spheroid tissue and to induce cell death via the extrinsic apoptosis pathway is examined. Both structure of the DNA origami and the attachment of the apoptosis‐inducing ligands are varied. The penetration is dependent on DNA origami size, not flexibility, but the apoptosis efficacy is dependent on ligand ...
Johann M. Weck, Riya Nair, Merve‐Z. Kesici, Xiaoyue Shang, Svetozar Gavrilović, Cornelia Monzel, Amelie Heuer‐Jungemann   +6 more
wiley   +1 more source

Potential benefits and risks of clinical xenotransplantation [PDF]

, 2012
The transplantation of organs and cells from pigs into humans could overcome the critical and continuing problem of the lack of availability of deceased human organs and cells for clinical transplantation.
Ayares, D, Cooper, DKC
core   +2 more sources

Unlocking Transplant Tolerance with Biomaterials

Advanced Healthcare Materials, Volume 14, Issue 5, February 18, 2025.
Transplantation holds great promise, but the lack of long‐term success outcomes highlights the need for more targeted therapeutics and insights from immune rejection mechanisms. This review delves into how biomaterials offer a versatile toolbox for engineering next‐generation therapeutics, emphasizing the inherent properties of materials that suit ...
John‐Paul A. Pham, María M. Coronel
wiley   +1 more source

CD95 recruits PLCγ1 to trigger a calcium response promoting Th17 accumulation in inflamed organs of lupus mice [PDF]

CD95 ligand (CD95L) is expressed by immune cells and triggers apoptotic death. Metalloprotease-cleaved CD95L (cl-CD95L) is released into the bloodstream but does not trigger apoptotic signaling.
Barrow, Paul A., Blanco, Patrick, Contin, Cecile, Ducret, Thomas, Dupuy, Alain, Fautrel, Alain, Flynn, Robin J., Forcade, Edouard, Jouan, Florence, Le Gallo, Matthieu, Legembre, Patrick, Levoin, Nicolas, Malleter, Marine, Morere, Lucie, Penna, Aubin, Poissonnier, Amanda, Poizeau, Florence, Rioux, Nathalie, Ritz, Jerome, Sanseau, Doriane, Seneschal, Julien, Vacher, Anne-Marie, Vacher, Pierre, Viel, Roselyne   +23 more
core  

Clinical-pathological study on β-APP, IL-1β, GFAP, NFL, Spectrin II, 8OHdG, TUNEL, miR-21, miR-16, miR-92 expressions to verify DAI-diagnosis, grade and prognosis [PDF]

, 2018
Traumatic brain injury (TBI) is one of the most important death and disability cause, involving substantial costs, also in economic terms, when considering the young age of the involved subject. Aim of this paper is to report a series of patients treated
A Frati, AA Hyder, AM Palmer, AW Selassie, B Buller, B Roozenbeek, CJ Murray, D Thurman, DH Smith, DK Menon, DM Stein, DR Li, EM Graham, F Masson, F Tagliaferri, FE Sherriff, FM Barabas, FM Shahim, G Illerhaus, H Bayir, HA Kontos, I Humphreys, JB Redell, JB Redell, JB Redell, JF Geddes, JH Adams, JT Povlishock, JT Povlishock, K Blennow, K Dams-O’Connor, K Fukuda, K Sakai, KM O’Connell, L Tao, M Oehmichen, M Oehmichen, M Ogata, M Valiyaveettil, M Ziu, MA Ansari, MB Grosjean, N Stoicea, OG Bhalala, PR Turner, R Sandhir, RM Chesnut, S Griffiths-Jones, S Griffiths-Jones, S Schiavone, S Thornhill, S Yokobori, SK Kwon, T Frugier, T Strickland, TY Sun, V Pietro Di, VA Tyurin, W Peeters, WL Maxwell, WX Wang, X Ge, X Ge, Y Li, Y Zhang, Z Hu   +65 more
core   +3 more sources

Активация триггерных механизмов апоптоза у больных артериальной гипертензией с сопутствующим сахарным диабетом 2 типа [PDF]

, 2016
Отмечена прямая зависимость у пациентов с артериальной гипертонией между уровнем глюкозы и плазматической активностью циркулирующих маркеров апоптоза FasL (CD95L) и FasR ...
Аль Шейкх Диб, Х. Х., Ащеулова, Т. В., Ковалева, О. Н.   +2 more
core