Results 161 to 170 of about 6,241 (179)

Spatial Organisation of Tumour cDC1 States Correlates with Effector and Stem-Like CD8⁺ T Cells Location. [PDF]

Eur J Immunol
Piot C, Pereira da Costa M, Biram A, Minutti CM, Lim KHJ, Green M, Mikolajczak A, Jenkins RP, Meader L, Buck MD, Cardoso A, Rogers N, Sahai E, Reis E Sousa C.   +13 more
europepmc   +1 more source

Some of the next articles are maybe not open access.

Related searches:

Mechanisms of CD40-dependent cDC1 licensing beyond costimulation

Nature Immunology, 2022
CD40 signaling in classical type 1 dendritic cells (cDC1s) is required for CD8 T cell-mediated tumor rejection, but the underlying mechanisms are incompletely understood. Here, we identified CD40-induced genes in cDC1s, including Cd70, Tnfsf9, Ptgs2 and Bcl2l1, and examined their contributions to anti-tumor immunity.
Renee Wu, Ray A. Ohara, Suin Jo, Tian-Tian Liu, Stephen T. Ferris, Feiya Ou, Sunkyung Kim, Derek J. Theisen, David A. Anderson, Brian W. Wong, Timothy Gershon, Robert D. Schreiber, Theresa L. Murphy, Kenneth M. Murphy   +13 more
openaire   +3 more sources

cDC1 Vaccines Drive Tumor Rejection by Direct Presentation Independently of Host cDC1

Cancer Immunology Research, 2022
Abstract As a cell-based cancer vaccine, dendritic cells (DC), derived from peripheral blood monocytes or bone marrow (BM) treated with GM-CSF (GMDC), were initially thought to induce antitumor immunity by presenting tumor antigens directly to host T cells.
Stephen T. Ferris, Ray A. Ohara, Feiya Ou, Renee Wu, Xiao Huang, Sunkyung Kim, Jing Chen, Tian-Tian Liu, Robert D. Schreiber, Theresa L. Murphy, Kenneth M. Murphy   +10 more
openaire   +2 more sources

Cancer immunity derailed: PGE2 misconducts cDC1s

Immunity, 2023
Type 1 conventional dendritic cells (cDC1s) are critical for CD8+ T cell-mediated tumor control. In this issue of Immunity, Bayerl et al.1 expose a mechanism leading to cancer progression where prostaglandin E2 induces dysfunctional cDC1s, which cannot coordinate CD8+ T cell migration and expansion.
Matthew Brown, Michelle A. Tran, Nina Bhardwaj   +2 more
openaire   +2 more sources

cDC1 to cDC2: “Everything I do, Ido1 it for you”

Immunity, 2022
Distinct dendritic cell (DC) subsets exert specific functions in immune regulation, but their communication with each other has remained elusive. In this issue of Immunity, Gargaro et al. identify the IDO1-Kyn-AHR axis as a metabolic signaling pathway through which conventional DC subsets communicate and induce tolerogenicity.
Mirja Tamara, Prentzell, Christiane A, Opitz   +1 more
openaire   +2 more sources

cDC1 and cancer

Science, 2020
Tumor Immunology A subset of immune cells called conventional dendritic cell 1 (cDC1) has been shown to play a critical role in antitumor responses. Hubert et al. now show that human cDC1 contribute to antitumor responses through the production of type III interferon, also known as IFN-γ1.
openaire   +1 more source

Who on IRF are you? IRF8 deficiency redirects cDC1 lineage commitment

Trends in Immunology, 2022
Interferon regulatory factor 8 (IRF8) has long been associated with conventional dendritic cell type I (cDC1) development. In a recent study, Lança et al. demonstrate that IRF8 is also crucial in cells already committed to the cDC1 lineage. Here, deletion of IRF8 from the XCR1-expressing pre-cDC1 stage onward leads to a loss of commitment and ...
Waller, Kathryn, Scott, Charlotte L.
openaire   +2 more sources

IRF8 and BATF3 interaction enhances the cDC1 specific Pfkfb3 gene expression

Cellular Immunology, 2022
Dendritic cells (DCs) play central role in innate as well as adaptive immune responses regulated by diverse DC subtypes that vary in terms of surface markers, transcriptional profile and functional responses. Generation of DC diversity from progenitor stage is tightly regulated by complex molecular inter-play between transcription factors.
Kuldeep Singh Chauhan, Annesa Das, Hemant Jaiswal, Irene Saha, Monika Kaushik, Virendra Kumar Patel, Prafullakumar Tailor   +6 more
openaire   +2 more sources

Unexplored horizons of cDC1 in immunity and tolerance

2020
Dendritic cells are a specialized subset of hematopoietic cells essential for mounting immunity against tumors and infectious disease as well as inducing tolerance for maintenance of homeostasis. DCs are equipped with number of immunoregulatory or stimulatory molecules that interact with other leukocytes to modulate their functions.
Sreekumar, Balan, Kristen J, Radford, Nina, Bhardwaj   +2 more
openaire   +2 more sources

Zbtb10 transcription factor is crucial for murine cDC1 activation and cytokine secretion

European Journal of Immunology, 2021
Abstract Dendritic cell (DC) activation and cytokine production is tightly regulated. In this study, we found that Zbtb10 expression is activation dependent and it is essential for the immunogenic function of cDC1.
Shuchi Smita, Arup Ghosh, Viplov Kumar Biswas, Abdul Ahad, Sreeparna Podder, Atimukta Jha, Kaushik Sen, Hans Acha‐Orbea, Sunil K. Raghav   +8 more
openaire   +2 more sources