Results 111 to 120 of about 29,622 (230)

Regulation of peroxiredoxin I activity by Cdc2-mediated phosphorylation

, 2019
Hydrogen peroxide is implicated as an intracellular messenger in various cellular responses such as proliferation and differentiation. Peroxiredoxin (Prx) I is a member of the peroxiredoxin family of peroxidases and contains a consensus site (Thr90-Pro ...
창동신, 강상원, 정우진
core   +1 more source

A single‐cell census of pulmonary endarterectomies tissue across different anatomical regions in chronic thromboembolic pulmonary hypertension

Clinical and Translational Medicine, Volume 16, Issue 10, October 2026.
This study provides the first intra‐individual, regional single‐cell comparison of main/lobar versus bifurcate pulmonary endarterectomy (PEA) specimens. It reveals distinct macrophage polarisation, divergent T‐cell compositions and pronounced smooth muscle cell (SMC)‐to‐myofibroblast transition in the bifurcate region. These findings highlight regional
Rui Zhang, Yunlong Zhang, Huiting Li, Jing Zhang, Shou Han, Xinbo Cheng, Qinhua Zhao, Jing He, Cijun Luo, Hongling Qiu, Jianfeng Zhang, Sugang Gong, Lan Wang   +12 more
wiley   +1 more source

cdc2 and the regulation of mitosis: six interacting mcs genes

, 1989
A cdc2-3w weel-50 double mutant of fission yeast displays a temperature-sensitive lethal phenotype that is associated with gross abnormalities of chromosome segregation and has been termed mitotic catastrophe.
Booher, R., Young, P., Molz, L., Beach, D., P. Young, D. Beach, L. Molz, R. Booher   +7 more
core   +1 more source

Endometrial mesenchymal stem cells isolated from menstrual blood repaired epirubicin-induced damage to human ovarian granulosa cells by inhibiting the expression of Gadd45b in cell cycle pathway

Stem Cell Research & Therapy, 2019
Background To explore the effect of mesenchymal stem cells isolated from menstrual blood (MB-MSCs) on epirubicin-induced damage to human ovarian granulosa cells (GCs) and its potential mechanisms.
Zhongrui Yan, Fengyi Guo, Qing Yuan, Yu Shao, Yedan Zhang, Huiyan Wang, Shaohua Hao, Xue Du   +7 more
doaj   +1 more source

Synovial Fluid Immune Cell Landscape in Juvenile Idiopathic Arthritis

European Journal of Immunology, Volume 56, Issue 10, October 2026.
Synovial fluid immune cells in juvenile idiopathic arthritis were profiled using single‐cell multiomics and flow cytometry. The immune landscape in synovial fluid was markedly distinct from that of blood and was enriched for dendritic cells, CD56hi NK cells, γδ T cells, CD4+ T peripheral helper and regulatory T cells, tissue‐resident memory CD8+ T ...
Viola Pitkänen, Bella Lappalainen, Marja Rytkönen‐Nissinen, Terhi Remes‐Pakarinen, Paula Vähäsalo, Milja Möttönen, Minna‐Maija Grönlund, Miika Arvonen, Liisa Kröger, Anna‐Mari Schroderus, Tuure Kinnunen   +10 more
wiley   +1 more source

Nocodazole induced suppression of the Cdc2 (Tyr15) phosphorylation inhibited by the LANA expression.

, 2014
(A) BJAB cells transfected with the pA3M vector or pA3M-LANA were treated with nocodazole (200 ng/mL) for 24 hours. The cells were then harvested, total cell lysate were prepared and western blot was performed using antibodies against cyclin B1, Cdc2 ...
Shanmugam Rajasubramaniam (590076), Suchitra Mohanty (590070), Asutosh K. Jha (590074), Chanakya N. Kundu (590075), Sushil Kumar Sahu (473592), Tathagata Choudhuri (473593), Santanu Maji (590072), Sudipta Chakrabarti (590071), Amit Kumar (81180), Chandan Goswami (156526), R. Rajendra Reddy (590073), Subhash C. Verma (198268)   +11 more
core   +1 more source

Artonol B and Sikloartobilosanton dari Artocarpus teysmanii MIQ

Journal of Mathematical and Fundamental Sciences, 2019
Dua senyawa masing-masing turunan santon lakton, yaitu artonol B (1) dan turunan furanodihidrobenzosanton, yakni Sikloartobilosanton (2), telah ditemukan pada tumbuhan Artocarpus teysmanii Miq.
Lukman Makmur, Syamsurizal Syamsurizal, Tukiran Tukiran, Yoharmus Syamsu, Sjamsul Arifin Achmad, Euis Holisotan Hakim, Didin Mujahidin, Norio Aimi, Mariko Kitajima, Hiromitsu Takayama   +9 more
doaj  

TGF‐β/Smad‐Associated Epithelial–Fibroblast Remodeling Underlies Collagen Deposition in Chronic Rhinosinusitis With Nasal Polyps

Immunity, Inflammation and Disease, Volume 14, Issue 10, October 2026.
ABSTRACT Background Chronic rhinosinusitis with nasal polyps (CRSwNP) is frequently accompanied by epithelial barrier disruption and tissue remodeling. This study aimed to investigate whether epithelial–mesenchymal transition (EMT), fibroblast activation, collagen deposition, and TGF‐β/Smad signaling are coordinated during CRSwNP nasal mucosal ...
Shilong Liu, Peizheng Xie, Hanwei Deng, Zhenhua Zhu   +3 more
wiley   +1 more source

The histone deacetylase HDAC1 controls dendritic cell development and anti-tumor immunity

Cell Reports
Summary: Dendritic cell (DC) progenitors adapt their transcriptional program during development, generating different subsets. How chromatin modifications modulate these processes is unclear.
Cristiano De Sá Fernandes, Philipp Novoszel, Tommaso Gastaldi, Dana Krauß, Magdalena Lang, Ramona Rica, Ana P. Kutschat, Martin Holcmann, Wilfried Ellmeier, Davide Seruggia, Herbert Strobl, Maria Sibilia   +11 more
doaj   +1 more source

Myeloid Focal Adhesion Kinase Promotes Macrophage Accumulation but Does Not Alter Tumor Progression in Hepatocellular Carcinoma

Molecular Carcinogenesis, Volume 65, Issue 10, Page 1209-1225, October 2026.
ABSTRACT Hepatocellular carcinoma (HCC) develops within an immunologically complex tumor microenvironment that is heavily shaped by infiltrating myeloid cells. Immune‐based treatment strategies such as atezolizumab plus bevacizumab have shown promising therapeutic benefits, but patients do not experience durable responses.
Eugene Ham, Kyle Boedeker, Claudia Rose Keating, Ruisong Ye, Frankie Montalbano, Sophia Mankaruse, Xianzhong Ding, Jonathan P. Rennhack, Wei Qiu   +8 more
wiley   +1 more source