Results 121 to 130 of about 29,264 (228)
MedComm, Volume 7, Issue 9, September 2026.This work synthesizes recent insights into the pathological roles of cyclins and cyclin‐dependent kinases (CDKs) across human cancers, highlights state‐of‐the‐art innovative approaches (especially targeted degradation and redistribution of CDK/cyclin proteins) for cancer therapy, and outlines future directions for CDK/cyclin‐related biomedical research.
Suya Zheng +9 more
wiley +1 more source
Role of cDC2 in priming CD8+ T cells in cancer
Journal for ImmunoTherapy of CancerType 2 conventional dendritic cell (cDC2) gene signature was shown to be associated with better overall survival in patients with lung cancer and a fraction of patients with breast carcinoma, indicating that they may possess antitumoral function ...
Damya Laoui, Ahmed E I Hamouda
doaj +1 more source
Advances in FGF/FGFR Signaling: Implications for Disease and Therapy
MedComm, Volume 7, Issue 9, September 2026.The FGF/FGFR signaling is indispensable for the maintenance of physiological homeostasis and governs multiple biological processes, including embryonic development, bone metabolism, angiogenesis, and neurogenesis, whereas aberrant hyperactivation of this pathway drives the progression of malignancies and autoimmune disorders, including inflammatory ...
Miaoyu Song +4 more
wiley +1 more source
Distinct ontogenetic lineages dictate cDC2 heterogeneity
Nature ImmunologyAbstractConventional dendritic cells (cDCs) include functionally and phenotypically diverse populations, such as cDC1s and cDC2s. The latter population has been variously subdivided into Notch-dependent cDC2s, KLF4-dependent cDC2s, T-bet+ cDC2As and T-bet− cDC2Bs, but it is unclear how all these subtypes are interrelated and to what degree they ...
Minutti, Carlos +14 more
openaire +3 more sources
British Journal of Haematology, Volume 209, Issue 3, Page 964-977, September 2026.Moderate DHX15, HNRNPL and RBM33 expression drives predominant AML1‐ETO mRNA production, while elevated expression of them promotes generating more AE9a mRNA (Aspartic acid ‐ Glutamic acid ‐ Alanine ‐ Aspartic acid sequence)(messenger ribonucleic acid).
Qiao Liu +13 more
wiley +1 more source
Chemical Biology &Drug Design, Volume 108, Issue 3, September 2026.HUHS199, a novel inhibitor of ALKBH3, suppresses glioblastoma cell proliferation, induces G1 cell cycle arrest, and increases RNA m1A levels, with concomitant changes in GADD45A mRNA methylation status, highlighting the pathological relevance of ALKBH3‐mediated RNA demethylation in glioblastoma.
Manami Yamada +10 more
wiley +1 more source
Cdc2 exists in three forms with distinct phosphorylation levels.
, 2015 (A) Phosphorylation of S.pombe Cdc2 at threonine-14 (T14), tyrosine-15 (Y15) and threonine-167 (T167). Cdc2.1w is insensitive to inhibition by Wee1 kinase, whereas Cdc2.3w does not require activation by Cdc25 phosphatase. (B+C) Model of S.pombe Cdc2. The
Victoria Hilditch (763611) +1 more
core +1 more source
Plasma Cell Selection and Migration in the Establishment of Long‐Lived Antibody Responses
Immunological Reviews, Volume 342, Issue 1, September 2026.ABSTRACT As B cells are activated and differentiate into plasma cells, they execute migration programs that allow them to traffic within secondary lymphoid tissues and reach the bone marrow, where they can mature as long‐lived plasma cells. Recent studies have revealed mechanisms underlying not only affinity‐driven but also isotype‐driven plasma cell ...
Wataru Ise +2 more
wiley +1 more source
Abi enhances Abl-mediated Cdc2 phosphorylation and inactivation
, 2008 [[abstract]]Abelson tyrosine kinase (Abl) is a non-receptor tyrosine kinase which is frequently coupled with adaptor proteins to interact with its substrates for the regulation of cytoskeleton rearrangement, cell growth and apoptosis in response to a ...
Lin, TY; Huang, CH; Chou, WG; Juang, JL
core +1 more source