Results 121 to 130 of about 29,622 (230)

Cdc2 kinase

, 1997
During larval development, Drosophila imaginal discs increase in size about 1000-fold and cells are instructed to acquire distinct fates as a function of their position.
Weigmann, K., Lehner, C., Stephen M. Cohen, Christian F. Lehner, Katrin Weigmann, Cohen, S.   +5 more
core   +1 more source

Phytochemicals as Multitarget Therapeutics in Pancreatic Cancer: Mechanisms, Clinical Evidence, and Translational Challenges

Phytotherapy Research, Volume 40, Issue 10, Page 5973-5987, October 2026.
Pancreatic cancer, particularly pancreatic ductal adenocarcinoma, is aggressive and often diagnosed late, making treatment challenging. This review highlights the potential of phytochemicals, such as curcumin and quercetin, as multitarget agents that influence key carcinogenic pathways. These compounds exhibit anticancer effects by inhibiting processes
Md. Rezaul Islam, Abdur Rauf, F. M. Shourav, Hanan A. Ogaly, Abdullah S. M. Aljohani, Waleed Al Abdulmonem, Kamala Badalova, Marcello Iriti   +7 more
wiley   +1 more source

Unraveling porcine dendritic-cell diversity: welcome tDC and DC3

Frontiers in Immunology
Dendritic cells (DC) are professional antigen presenting cells playing a major role in orchestrating adaptative immune responses. To adapt to various immune challenges, such as different classes of pathogens, specialized subsets of DC have evolved across
Ambre Baillou, Ambre Baillou, Gaël Auray, Gaël Auray, Francisco Brito, Francisco Brito, Marius Botos, Marius Botos, Alizée Huber, Alizée Huber, Artur Summerfield, Artur Summerfield, Stephanie C. Talker, Stephanie C. Talker   +13 more
doaj   +1 more source

Spatial and Single‐Cell Multi‐Omics Analyses of T‐Cell Subsets and Interactions in Melanoma Lymph Node Metastasis

Experimental Dermatology, Volume 35, Issue 10, October 2026.
This figure illustrates how single‐cell and spatial multi‐omics can be applied to map T‐cell states and immune organisation in melanoma tumour‐draining lymph nodes (TDLNs). During regional immune remodelling and nodal metastasis, immune‐active and immune‐suppressed regions may coexist within the same tissue.
Ras Azira Ramli, Samuel Tan, Yibi Chen, Glen Boyle, Quan Nguyen   +4 more
wiley   +1 more source

Pro-apoptotic role of Cdc25A: Activation of cyclin B1/Cdc2 by the Cdc25A C-terminal domain

, 2010
[[abstract]]Cdc25A is a dual-specificity protein phosphatase that activates Cyclin/Cyclin-dependent protein kinase (Cdk) complexes by removing inhibitory phosphates from conserved threonine and tyrosine in Cdks.
Chou, ST;Yen, YC;Lee, CM;Chen, MS
core   +1 more source

Erianin inhibits proliferation of activated T cells by downregulating CyclinB1

陆军军医大学学报
Objective To investigate the inhibitory effect of erianin on T cell proliferation and its underlying mechanism. Methods Peripheral blood mononuclear cells (PBMCs) were isolated using density gradient centrifugation, and T cells were purified by ...
JING Lin, ZHANG Ting, LUO Xinyan
doaj   +1 more source

cDC2 subsets [PDF]

Nature Immunology, 2019
openaire   +2 more sources

Prophylactic Inhalation of Bergamot Essential Oil Ameliorates Hormone‐Simulated Pseudopregnancy Withdrawal‐Induced Postpartum Depression by Modulating Hippocampal Synaptic Plasticity

Journal of Cellular and Molecular Medicine, Volume 30, Issue 20, October 2026.
ABSTRACT Postpartum depression (PPD) affects approximately 17.2% of women giving birth globally, but current pharmacotherapies face significant limitations including invasive intravenous delivery (brexanolone) and high costs Bergamot essential oil (BEO) has demonstrated efficacy in aromatherapy for depression, yet its role in PPD remains unexplored ...
Huan Xu, Shike Zhang, Hui He, Xue Zhao, Yupei Cheng, Yingdong Wang, Jinzhou Li, Yi Yu, Yuhong Bian, Yi Guo, Mingxing Zhang   +10 more
wiley   +1 more source

Up-regulation of cdc2 protein during paclitaxel-induced apoptosis

, 2000
International audienceMicrotubule damages induced by paclitaxel inhibit proteasome-dependent degradation of cyclin B, resulting in a sustained activation of cyclin B/cdc2 kinase and a cell cycle arrest in mitosis.
Truchet, Isabelle, Valette, Annie, Brichese, Laetitia, Chadebech, Philippe, Meier R, Giovanoli O, Nooijen, Peet T.G.A., Humar B, Ten Hagen, Timo L.M., Eggermont, Alexander M.M., Parent, Marie-Élise, Attenhofer M, Müller H, Bendik I, Van Tiel, Sandra T.; id_orcid, Siemiatycki, Jack, Seynhaeve, Ann L.B., Dobbie Z, Van Der Veen, Alexander H., Wolf A, Dumas, Simone, Brisson, Jacques   +21 more
core   +1 more source

Role of cDC2 in priming CD8+ T cells in cancer

Journal for ImmunoTherapy of Cancer
Type 2 conventional dendritic cell (cDC2) gene signature was shown to be associated with better overall survival in patients with lung cancer and a fraction of patients with breast carcinoma, indicating that they may possess antitumoral function ...
Damya Laoui, Ahmed E I Hamouda
doaj   +1 more source