Results 101 to 110 of about 29,622 (230)
Phosphorylation substrates of Cdc2 that are transcription factors themselves.
, 2018 Phosphorylation substrates of Cdc2 that are transcription factors themselves.
Dania Humaidan (6041318) +2 more
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cdc2–cyclin B regulates eEF2 kinase activity in a cell cycle- and amino acid-dependent manner [PDF]
, 2008 The calcium/calmodulin-dependent kinase that phosphorylates and inactivates eukaryotic elongation factor 2 (eEF2 kinase; eEF2K) is subject to multisite phosphorylation, which regulates its activity.
Proud, C. +5 more
core +1 more source
Blocking CHK1 Expression Induces Apoptosis and Abrogates the G2 Checkpoint Mechanism
Neoplasia: An International Journal for Oncology Research, 2001 Checkpoint kinase 1 (Chki) is a checkpoint gene that is activated after DNA damage. It phosphorylates and inactivates the Cdc2 activating phosphatase Cdc25C. This in turn inactivates Cdc2, which leads to G2/M arrest.
Yan Luo +8 more
doaj +1 more source
Investigating CD8 T Cell Exhaustion in Chronic LCMV Infection by Flow Cytometry
Current Protocols, Volume 6, Issue 10, October 2026.Abstract CD8 T cells and the process of T cell exhaustion are central topics in both basic immunology and translational research, including clinical applications. Here, we provide a comprehensive, step‐by‐step guide to investigate CD8 T cells in murine in vivo lymphocytic choriomeningitis virus (LCMV) infection models.
Dominique Stark +5 more
wiley +1 more source
Cloning of the Eh cdc2 gene from Entamoeba histolytica encoding a protein kinase p34cdc2 homologue
, 1993 To understand better growth regulation in the protozoan parasite, Entamoeba histolytica (Eh), a homologue of the cdc2 gene encoding the yeast cyclin-dependent protein kinase, p34cdc2, has been cloned and sequenced.
Samuelson, John, Lohia, Anuradha
core +1 more source
Fungal immunization potentiates CD4+ T cell-independent cDC2 responses for cross-presentation
Frontiers in ImmunologyThe incidence rates of fungal infections are increasing, especially in immunocompromised individuals without an FDA-approved vaccine. Accumulating evidence suggests that T cells are instrumental in providing fungal immunity.
Nitish A. Kulkarni +2 more
doaj +1 more source
Clinical and Translational Discovery, Volume 6, Issue 5, October 2026.This review provides a comprehensive overview of how macrophages, neutrophils, T cells and other immune cells infiltrate the aortic wall, undergo phenotypic shifts and interact with one another in abdominal aortic aneurysm (AAA). Background Abdominal aortic aneurysm (AAA) is a lethal degenerative vascular disease with no approved clinical drugs. Immune
Junqi Peng +3 more
wiley +1 more source
Phosphorylation of amyloid-ß at the serine 26 residue by human cdc2 kinase
, 2001 The amyloid-β (Aβ) peptide has been implicated in the pathology of Alzheimer's disease (AD). Using an antisense peptide approach a novel interaction between Aβ and the human cdc2 kinase was identified.
Milton, N.G.N.
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Clinical and Translational Medicine, Volume 16, Issue 10, October 2026.ACKR1+ endothelial cells mark intraplaque neovessels with hyperactive glycolysis and lactate metabolism. Lactate, HIF‐1α and CXCL12 link this state to CXCR4+ CD8+ T‐cell recruitment in situ. SLC16A3 and SLC16A4 serve as quantitative readouts of this lactate–immune state.
Ji Zhang +10 more
wiley +1 more source
Expression of P34(Cdc2) in Oral Epithelial Dysplasia and Oral Squamous Cell Carcinoma
, 2011 Overexpression of p34(cdc2) has been demonstrated in a variety of human cancers and found to be significantly associated with the tumor size, lymph node metastasis, clinical stage, and prognosis of these cancers. In this study, we examined the expression
林彥宏;洪千雁;余權航;張嘉銓;王逸平;郭儒銓;郭英雄;郭生興;江俊斌 +1 more
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