Results 181 to 190 of about 29,622 (230)

Heterogeneity of the intestinal mononuclear phagocyte compartment in health and inflammatory bowel disease. [PDF]

Sci Immunol
Fenton TM, Wulff L, Väänänen V, Jones GR, Lemvigh CK, Riis LB, Wewer MD, Vandamme J, Jørgensen PB, Bain CC, Belling KG, Ho GT, Pers TH, Poulsen A, Madsen GR, Nielsen OH, Jakobsen HL, Izarzugaza JM, Bendtsen F, Brunak S, Mowat AM, Olsen LR, Mörbe U, Agace WW.   +23 more
europepmc   +1 more source

IRF8 deficiency induces the transcriptional, functional, and epigenetic reprogramming of cDC1 into the cDC2 lineage

Immunity, 2022
Conventional dendritic cells (cDCs) consist of two major functionally and phenotypically distinct subsets, cDC1 and cDC2, whose development is dependent on distinct sets of transcription factors.
Allan Mowat, Thorsten Joeris, Knut Kotarsky   +2 more
exaly   +2 more sources

Association with Cdc2 and inhibition of Cdc2/Cyclin B1 kinase activity by the p53-regulated protein Gadd45 [PDF]

Oncogene, 1999
Recently Gadd45, a p53-regulated stress protein, has been implicated in the activation of a G2/M checkpoint after damage by UV radiation and alkylating agents. While inhibitory phosphorylation of Cdc2 and suppression of cyclin B1 levels are known to be involved in G2 delays after genotoxic stress, Gadd45 has now been found to directly inhibit the ...
Albert J Fornace, Xin Wei Wang, France Carrier   +2 more
exaly   +3 more sources

Centrosomal and Cytoplasmic Cdc2/Cyclin B1 Activation Precedes Nuclear Mitotic Events

Experimental Cell Research, 2000
The activation of cdc2/cyclin B is the trigger for entry into mitosis. The mechanism of cdc2/cyclin B activation is complex, but the final step is the dephosphorylation of the Thr14 and Tyr15 residues on the cdc2 subunit, catalyzed by a member of the ...
Brian Gabrielli, K A Ellem
exaly   +2 more sources

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The fission yeast cell cycle control gene cdc2: structure of the cdc2 region

Molecular Genetics and Genomics, 1985
The cdc2 cell cycle control gene of Schizosaccharomyces pombe has been identified on a 3 kb DNA fragment. The gene is unique in the genome and is located near to a 5S ribosomal RNA gene. When a plasmid containing DNA sequences adjacent to the cdc2 gene is transformed into certain temperature sensitive cdc2 mutants it allows colony formation at the ...
Paul Nurse, Barbara Durkacz, David Beach
exaly   +2 more sources

Cdc2 regulatory factors

Current Opinion in Cell Biology, 1994
A growing family of kinases and phosphatases controls the activity of the cyclin-dependent kinase cdc2. The past year has seen the identification of the cdk activating kinase as well as considerable elucidation of the cdc25/wee1 regulatory pathways. Both cdc25 and wee1 appear to be regulated by upstream kinase/phosphatase networks.
T R, Coleman, W G, Dunphy
openaire   +2 more sources