Results 191 to 200 of about 29,622 (230)

Neuronal cdc2-like kinase

Trends in Biochemical Sciences, 1995
Neurofilament proteins and the neuron-specific microtubule-associated protein tau are phosphorylated in vivo at sites conforming to the phosphorylation consensus motif of the cell-cycle-control protein kinase, p34cdc2-cyclin. Abnormalities in the phosphorylation of these proteins are associated with neurodegenerative disorders, such as amylotrophic ...
J, Lew, J H, Wang
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Phosphorylation of Dynamin by CDC2 Kinase

Biochemical and Biophysical Research Communications, 1994
A 100kD microtubule-bundling protein dynamin was phosphorylated in vitro by cdc2 kinase to approximately 1 mol of phosphate/mol of dynamin at a serine residue. These phosphorylations of dynamin greatly reduced its binding ability to microtubules.
H, Hosoya, S, Komatsu, T, Shimizu, M, Inagaki, M, Ikegami, K, Yazaki   +5 more
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Movin' on through with Cdc2

Nature Cell Biology, 2003
Proteins that control the cell cycle would seem to have little to do with cell migration. However, a recent report indicates that Cdc2, a key cyclin-dependent kinase, can also enhance cell migration. Levels of Cdc2 are upregulated in cells that express high levels of the αvβ3 integrin, a protein that has long been implicated in enhanced migration and ...
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Molecular cloning and sequence analysis of mutant alleles of the fission yeast cdc2 protein kinase gene: Implications for cdc2 + protein structure and function

Molecular Genetics and Genomics, 1989
The cdc2+ gene function plays a central role in the control of the mitotic cell cycle of the fission yeast Schizosaccharomyces pombe. Recessive temperature-sensitive mutations in the cdc2 gene cause cell cycle arrest when shifted to the restrictive ...
Jacqueline Hayles, Paul Nurse
exaly   +1 more source

Elevation of cyclin B1, active cdc2, and HuR in cervical neoplasia with human papillomavirus type 18 infection

Cancer Letters, 2006
Over 30 cervical epitheliotrophic HPV types may lead to altered biological functions that affect the clinical outcome of HPV infection. In order to determine the regulatory mechanism and effect of different HPV subtypes, we performed functional assays on
Nam-Hoon Cho, Hee-Jung An, Suki Kang
exaly   +2 more sources

Genetic analysis of the Drosophila cdc2 homolog

Development, 1993
ABSTRACT We have identified mutations in the Drosophila cdc2 gene. The recessive lethality of these mutant alleles was rescued after P-element-mediated transformation with a genomic cdc2 fragment. Sequence analysis of amorphic alleles revealed non-conservative exchanges in evolutionary conserved positions.
Stern, B., Ried, G., Clegg, N., Grigliatti, T., Lehner, C.   +4 more
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Cloning of cDNAs encoding Bombyx homologues of Cdc2 and Cdc2‐related kinase from eggs

Insect Molecular Biology, 1997
Abstract In diapausing eggs of the silkworm, Bombyx mori , embryonic cells are arrested at G 2 phase. The ability to undertake cell division is resumed in the course of diapause termination caused by such a treatment as acclimation to ...
H, Iwasaki, M, Takahashi, T, Niimi, O, Yamashita, T, Yaginuma   +4 more
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CDK9 (PITALRE): A multifunctional cdc2-related kinase

Journal of Cellular Physiology, 1998
CDK9 is a cdc2-related kinase protein. Previously named PITALRE, this protein is a serine-threonine kinase involved in many physiological processes. Unlike most of the cdc2-like kinases, its activity is not cell cycle-regulated. CDK9 acts preferentially in processes different from cell-cycle regulation, such as differentiation.
de Falco G., Giordano A.
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Phosphorylation of Synthetic Vimentin Peptides by CDC2 Kinase

Biochemical and Biophysical Research Communications, 1993
Synthetic peptide representing the site Ser-41 in vimentin, Leu-Gly-Ser41-Ala42-Leu-Arg44-Arg-Arg-NH2, and its analogs in which Ala-42 was replaced by various amino acids were tested as substrates for cdc2 kinase. Among them, the analog containing sarcosine as well as proline was an excellent substrate.
S, Ando, K, Tsujimura, Y, Matsuoka, T, Tokui, S, Hisanaga, E, Okumura, M, Uchiyama, T, Kishimoto, H, Yasuda, M, Inagaki   +9 more
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Beacon interacts with cdc2/cdc28-like kinases

Biochemical and Biophysical Research Communications, 2003
Previously we found elevated beacon gene expression in the hypothalamus of obese Psammomys obesus. Beacon administration into the lateral ventricle of P. obesus stimulated food intake and body weight gain. In the current study we used yeast two-hybrid technology to screen for proteins in the human brain that interact with beacon.
Kantham, Lakshmi, Kerr-Bayles, Lyndal, Godde, Nathan, Quick, Melissa, Webb, Ryan, Sunderland, Terry, Bond, Judy, Walder, Ken, Augert, Guy, Collier, Greg   +9 more
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