Results 191 to 200 of about 29,264 (228)

Genetic analysis of the Drosophila cdc2 homolog

Development, 1993
ABSTRACT We have identified mutations in the Drosophila cdc2 gene. The recessive lethality of these mutant alleles was rescued after P-element-mediated transformation with a genomic cdc2 fragment. Sequence analysis of amorphic alleles revealed non-conservative exchanges in evolutionary conserved positions.
Stern, B., Ried, G., Clegg, N., Grigliatti, T., Lehner, C.   +4 more
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Cloning of cDNAs encoding Bombyx homologues of Cdc2 and Cdc2‐related kinase from eggs

Insect Molecular Biology, 1997
Abstract In diapausing eggs of the silkworm, Bombyx mori , embryonic cells are arrested at G 2 phase. The ability to undertake cell division is resumed in the course of diapause termination caused by such a treatment as acclimation to ...
H, Iwasaki, M, Takahashi, T, Niimi, O, Yamashita, T, Yaginuma   +4 more
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CDK9 (PITALRE): A multifunctional cdc2-related kinase

Journal of Cellular Physiology, 1998
CDK9 is a cdc2-related kinase protein. Previously named PITALRE, this protein is a serine-threonine kinase involved in many physiological processes. Unlike most of the cdc2-like kinases, its activity is not cell cycle-regulated. CDK9 acts preferentially in processes different from cell-cycle regulation, such as differentiation.
de Falco G., Giordano A.
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Phosphorylation of Synthetic Vimentin Peptides by CDC2 Kinase

Biochemical and Biophysical Research Communications, 1993
Synthetic peptide representing the site Ser-41 in vimentin, Leu-Gly-Ser41-Ala42-Leu-Arg44-Arg-Arg-NH2, and its analogs in which Ala-42 was replaced by various amino acids were tested as substrates for cdc2 kinase. Among them, the analog containing sarcosine as well as proline was an excellent substrate.
S, Ando, K, Tsujimura, Y, Matsuoka, T, Tokui, S, Hisanaga, E, Okumura, M, Uchiyama, T, Kishimoto, H, Yasuda, M, Inagaki   +9 more
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Beacon interacts with cdc2/cdc28-like kinases

Biochemical and Biophysical Research Communications, 2003
Previously we found elevated beacon gene expression in the hypothalamus of obese Psammomys obesus. Beacon administration into the lateral ventricle of P. obesus stimulated food intake and body weight gain. In the current study we used yeast two-hybrid technology to screen for proteins in the human brain that interact with beacon.
Kantham, Lakshmi, Kerr-Bayles, Lyndal, Godde, Nathan, Quick, Melissa, Webb, Ryan, Sunderland, Terry, Bond, Judy, Walder, Ken, Augert, Guy, Collier, Greg   +9 more
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Demonstration of cdc2 kinase in mature neuronal nuclei

NeuroReport, 1993
Immunocytochemistry has been used to assess the distribution of the mitosis-associated protein kinase, cdc2, in mature neurons of rat brain. A robust signal is apparent in most, but not all neurons in cerebellum, cortex and hippocampus. The signal is concentrated in neuronal nuclei with lower levels of immunoreactivity in neuronal cytoplasm.
J G, Wood, P, Zinsmeister
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Phosphorylation of NF-I in Vitro by cdc2 Kinase

Biochemical and Biophysical Research Communications, 1993
Nuclear factor I (NF-I) was purified to near homogeneity from Ehrlich ascites tumor cells. Mouse NF-I consisted of two peptides with relative molecular masses of 53 and 55 kDa and bound to the authentic NF-I site of the adenovirus DNA with no significant affinity with the CCAAT box.
H, Kawamura, K, Nagata, Y, Masamune, Y, Nakanishi   +3 more
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Cdk2/cdc2 expression in colon carcinogenesis and effects of cdk2/cdc2 inhibitor in colon cancer cells.

International Journal of Oncology, 1998
Cyclin dependent kinases propel the cell cycle in collaboration with cyclins. We have examined the expression of cdk2/cdc2 in adenoma and focal carcinoma in adenomatous tissue to explore their role in tumorigenesis of colorectum. Immunohistochemical study revealed that cdk2/cdc2 was overexpressed in a subsets of adenoma (14/50; 28.0%) but this ...
H, Yamamoto, T, Monden, H, Miyoshi, H, Izawa, K, Ikeda, M, Tsujie, T, Ohnishi, M, Sekimoto, N, Tomita, M, Monden   +9 more
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Regulatory properties of neuronal cdc2-like kinase

Molecular and Cellular Biochemistry, 1995
Neuronal cdc2-like kinase, nclk, is a heterodimer of cyclin dependent protein kinase 5, cdk5, and a 25 kDa subunit derived from a novel, neuron-specific, 35 kDa protein: p35. The characterization and regulation of nclk will be summarized in this minireview.
Qi, Robert Zhong, Yang, D., Matsuura, I., Lee, K.Y., Zhu, X., Huang, Q.Q., Wang, J.H.   +6 more
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Molecular evolution of cdc2 pseudogenes in spruce (Picea)

Plant Molecular Biology, 1998
The p34cdc2 protein and other cyclin-dependent protein kinases (CDK) are important regulators of eukaryotic cell cycle progression. We have previously cloned a functional cdc2 gene from Picea abies and found it to be part of a family of related sequences, largely consisting of pseudogenes. We now report on the isolation of partial cdc2 pseudogenes from
A, Kvarnheden, V A, Albert, P, Engström
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