Results 201 to 210 of about 29,622 (230)

Demonstration of cdc2 kinase in mature neuronal nuclei

NeuroReport, 1993
Immunocytochemistry has been used to assess the distribution of the mitosis-associated protein kinase, cdc2, in mature neurons of rat brain. A robust signal is apparent in most, but not all neurons in cerebellum, cortex and hippocampus. The signal is concentrated in neuronal nuclei with lower levels of immunoreactivity in neuronal cytoplasm.
J G, Wood, P, Zinsmeister
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Phosphorylation of NF-I in Vitro by cdc2 Kinase

Biochemical and Biophysical Research Communications, 1993
Nuclear factor I (NF-I) was purified to near homogeneity from Ehrlich ascites tumor cells. Mouse NF-I consisted of two peptides with relative molecular masses of 53 and 55 kDa and bound to the authentic NF-I site of the adenovirus DNA with no significant affinity with the CCAAT box.
H, Kawamura, K, Nagata, Y, Masamune, Y, Nakanishi   +3 more
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Cdk2/cdc2 expression in colon carcinogenesis and effects of cdk2/cdc2 inhibitor in colon cancer cells.

International Journal of Oncology, 1998
Cyclin dependent kinases propel the cell cycle in collaboration with cyclins. We have examined the expression of cdk2/cdc2 in adenoma and focal carcinoma in adenomatous tissue to explore their role in tumorigenesis of colorectum. Immunohistochemical study revealed that cdk2/cdc2 was overexpressed in a subsets of adenoma (14/50; 28.0%) but this ...
H, Yamamoto, T, Monden, H, Miyoshi, H, Izawa, K, Ikeda, M, Tsujie, T, Ohnishi, M, Sekimoto, N, Tomita, M, Monden   +9 more
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Regulatory properties of neuronal cdc2-like kinase

Molecular and Cellular Biochemistry, 1995
Neuronal cdc2-like kinase, nclk, is a heterodimer of cyclin dependent protein kinase 5, cdk5, and a 25 kDa subunit derived from a novel, neuron-specific, 35 kDa protein: p35. The characterization and regulation of nclk will be summarized in this minireview.
Qi, Robert Zhong, Yang, D., Matsuura, I., Lee, K.Y., Zhu, X., Huang, Q.Q., Wang, J.H.   +6 more
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Molecular evolution of cdc2 pseudogenes in spruce (Picea)

Plant Molecular Biology, 1998
The p34cdc2 protein and other cyclin-dependent protein kinases (CDK) are important regulators of eukaryotic cell cycle progression. We have previously cloned a functional cdc2 gene from Picea abies and found it to be part of a family of related sequences, largely consisting of pseudogenes. We now report on the isolation of partial cdc2 pseudogenes from
A, Kvarnheden, V A, Albert, P, Engström
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The substrates of the cdc2 kinase.

Seminars in cell biology, 1993
The eukaryotic cell cycle is characterized by two major events, DNA replication (S phase) and mitosis (M phase). According to the current paradigm of the cell cycle as a cdc2 cycle, both of these events are driven by serine-threonine specific protein kinases encoded by functional homologs of the fission yeast cdc2 gene.
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Regulation of Cdc2 activity by phosphorylation at T14/Y15

1996
The highly conserved Cdc2 serine/threonine kinase plays a central role in cell cycle progression. Although Cdc2 levels remain constant throughout the cell cycle, Cdc2 kinase activity peaks at the G2/M boundary, in order to drive entry into mitosis.
L D, Berry, K L, Gould
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Activation of the various cyclin/cdc2 protein kinases

Current Opinion in Cell Biology, 1993
Recent research has led to the near culmination of the biochemical confirmation of the most basic genetic predictions about how p34cdc2 activity is controlled. The field is now moving from a biochemical dissection of the machinery to understanding how the system is regulated.
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CDC2

2008
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Role of inhibitory CDC2 phosphorylation in radiation-induced G2 arrest in human cells.

Journal of Cell Biology, 1996
David O. Morgan
exaly