Results 101 to 110 of about 6,022 (190)

Unaltered maximal power and submaximal performance correlates with an oxidative vastus lateralis proteome phenotype during tapering in male cyclists

Physiological Reports, Volume 13, Issue 8, April 2025.
Abstract Little is known on how a short‐term reduction of training volume changes muscle proteome and physiological parameters. We investigated the impact of halving training volume during regular training of cyclists on physiological parameters in relation to vastus lateralis protein profiles and fiber percentage ratios. Fifteen male cyclists (age: 30.
Pieter de Lange, Giuseppe Petito, Hannah L. Notbohm, Antonia Giacco, Giovanni Renzone, Elena Silvestri, Arianna Cuomo, Frank Suhr, Thorsten Schiffer, Jonas Zacher, Federica Cioffi, Rosalba Senese, Andrea Scaloni, Moritz Schumann, Wilhelm Bloch   +14 more
wiley   +1 more source

Therapeutic Effect of Targeting Branched-Chain Amino Acid Catabolic Flux in Pressure-Overload Induced Heart Failure. [PDF]

, 2019
Background Branched-chain amino acid (BCAA) catabolic defect is an emerging metabolic hallmark in failing hearts in human and animal models. The therapeutic impact of targeting BCAA catabolic flux under pathological conditions remains understudied ...
Chen, Mengping, Chuang, David T, Gao, Chen, Ren, Shuxun, Sun, Haipeng, Wang, Menglong, Wang, Yibin, Wynn, R Max, Yu, Jiayu   +8 more
core   +1 more source

Targeting Hsp90α to inhibit HMGB1‐mediated renal inflammation and fibrosis

Cell Proliferation, Volume 58, Issue 3, March 2025.
The polyphenol derivative 5,2′‐dibromo‐2,4′,5′‐trihydroxydiphenylmethanone (LM49) synthesized by our group can effectively ameliorate unilateral ureteral obstruction‐ and folic acid‐induced renal fibrosis, which is connected to the suppression of high‐mobility group box 1 (HMGB1)‐induced inflammation and tubular epithelial cell necrosis.
Huizhi Wei, Jinhong Ren, Xiue Feng, Chengxiao Zhao, Yuanlin Zhang, Hongxia Yuan, Fan Yang, Qingshan Li   +7 more
wiley   +1 more source

Pleomorphic adenoma and carcinoma ex‐pleomorphic adenoma tumorigenesis: A proteomic analysis

Oral Diseases, Volume 31, Issue 3, Page 865-878, March 2025.
Abstract Objectives To conduct a comprehensive proteomic analysis of normal salivary gland tissue, pleomorphic adenoma (PA), and carcinoma ex‐pleomorphic adenoma (CXPA), and validate the proteomic findings using immunohistochemistry. Methods Six normal salivary gland tissues, seven PA and seven CXPA samples underwent laser microdissection followed by ...
Virgílio Gonzales Zanella, Sara Ferreira Dos Santos Costa, Lauren Frenzel Schuch, Emily Ferreira Salles Pilar, Adriana Franco Paes Leme, Jean Nunes dos Santos, Syed Ali Khurram, Fatima Elalawy, Lynne Bingle, Fabio Daumas Nunes, Felipe Paiva Fonseca, Pablo Agustin Vargas, Manoela Domingues Martins, Vivian Petersen Wagner   +13 more
wiley   +1 more source

Stimulation of CK2-dependent Grp94 phosphorylation by the nuclear localization signal peptide. [PDF]

, 2011
The nuclear localization signal sequence (NLS) of SV40 Large T antigen is essential and sufficient for the nuclear translocation of the protein. Phosphorylation often modulates the intracellular distribution of signaling proteins.
Miyata, Yoshihiko, Yahara, Ichiro, Yoneda, Yoshihiro   +2 more
core   +1 more source

Sex‐dependent molecular landscape of Alzheimer's disease revealed by large‐scale single‐cell transcriptomics

Alzheimer's &Dementia, Volume 21, Issue 2, February 2025.
Abstract INTRODUCTION Alzheimer's disease (AD) shows significant sex differences in prevalence and clinical manifestations, but the underlying molecular mechanisms remain unclear. METHODS This study used a large‐scale, single‐cell transcriptomic atlas of the human prefrontal cortex to investigate sex‐dependent molecular changes in AD.
Mohamed Soudy, Sophie Le Bars, Enrico Glaab   +2 more
wiley   +1 more source

Profiling humoral autoimmune repertoire of dilated cardiomyopathy (DCM) patients and development of a disease-associated protein chip

, 2006
Dilated cardiomyopathy (DCM) is a myocardial disease characterized by progressive depression of myocardial contractile function and ventricular dilatation.
Cahill, D., Felix, S., Gutjahr, C., Horn, S., König, A., Landsberger, M., Lehrach, H., Lueking, A., Murphy, D., Schulte, K., Staudt, A.   +10 more
core   +1 more source

Post-translational deregulation of YAP1 is genetically controlled in rat liver cancer and determines the fate and stem-like behavior of the human disease [PDF]

, 2016
Previous studies showed that YAP1 is over-expressed in hepatocellular carcinoma (HCC). Here we observed higher expression of Yap1/Ctgf axis in dysplastic nodules and HCC chemically-induced in F344 rats, genetically susceptible to hepatocarcinogenesis ...
Avila, Matias A., Berasain, Carmen, Brozzetti, Stefania, Calvisi, Diego F., Daino, Lucia, Demartis, Maria I., Feo, Claudio F., Feo, Francesco, Latte, Gavinella, Pascale, Rosa M., Porcu, Alberto, Seddaiu, Maria A., Simile, Maria M., Tomasi, Maria L.   +13 more
core   +2 more sources

Epidermal growth factor receptor promotes osteoclast differentiation probably through regulating ABCC1 and CDC37

陆军军医大学学报
Objective To observe the expression profile of epidermal growth factor receptor (EGFR) during the differentiation of osteoclasts, and to explore EGFR-related signaling pathways and key genes during the process.
TAN Xin, ZHANG Ziyuan, LIU Xing
doaj   +1 more source

STRAD Pseudokinases Regulate Axogenesis and LKB1 Stability [PDF]

, 2014
BACKGROUND: Neuronal polarization is an essential step of morphogenesis and connectivity in the developing brain. The serine/threonine kinase LKB1 is a key regulator of cell polarity, metabolism, tumorigenesis, and is required for axon formation.
Baas, Annette F., Barnes, Anthony P., Brown, Allyson, Clevers, Hans, Edmonds, Benjamin, Gardner, Alexandria P., Gaucher, Eric A., Hansen, Kelly, Klug, Lillian R., Rielly, Gabrielle, Smart, James L., Subbiah, Krishnaveni, Veleva-Rotse, Biliana O., Zhao, Zi-ming   +13 more
core   +3 more sources