Results 91 to 100 of about 86,770 (308)
Cloning and differential expression analyses of Cdc42 from sheep
Journal of Veterinary Research, 2018 Serological diagnosis of brucellosis is still a great challenge due to the infeasibility of discriminating infected animals from vaccinated ones, so it is necessary to search for diagnostic biomarkers for differential diagnosis of brucellosis.
Yang Yong-Jie +10 more
doaj +1 more source
Scientific Reports, 2022 The small GTPase Cdc42 is an integral component of the cytoskeleton, and its dysregulation leads to pathophysiological conditions, such as cancer. Binding of Cdc42 to the scaffold protein IQGAP1 stabilizes Cdc42 in its active form.
Samar Sayedyahossein +14 more
doaj +1 more source
Allosteric Activation of the Par-6 PDZ Via a Partial Unfolding Transition [PDF]
, 2013 Proteins exist in a delicate balance between the native and unfolded states, where thermodynamic stability may be sacrificed to attain the flexibility required for efficient catalysis, binding, or allosteric control.
Kovrigin, Evgeni L. +3 more
core +2 more sources
Molecules, 2018 Despite great improvements in the diagnosis and treatment of neoplasms, metastatic disease is still the leading cause of death in cancer patients, with mortality rates still rising.
Xing-Hua Xiao +6 more
semanticscholar +1 more source
The Journal of Cell Biology, 2008 ![Graphic][1] Epithelial cells are already polarized by the first division, as indicated by the presence of the apical marker ZO-1 (red) on the cells' inner surfaces. During development, epithelial cells need a little help figuring out which way is up.
openaire +1 more source
The Novel Cdc42 Guanine Nucleotide Exchange Factor, Zizimin1, Dimerizes via the Cdc42-binding CZH2 Domain [PDF]
Journal of Biological Chemistry, 2004 Rho family small GTPases are critical regulators of multiple cellular processes and activities. Dbl homology domain-containing proteins are the classical guanine nucleotide exchange factors (GEFs) responsible for activation of Rho proteins. Recently another group of mammalian Rho-GEFs was discovered that includes CDM (Ced-5, DOCK180, Myoblast city ...
Nahum, Meller +4 more
openaire +2 more sources
Advanced Science, EarlyView.This study revealed that low expression of YTHDC1 in TMZ‐resistant GBM cells leads to increased FSCN1 expression, which is suppressed by m6A modification. FSCN1 activates the CDC42/N‐WASP/Arp2/3 axis in the cell nucleus by recruiting the guanine nucleotide exchange factor (GEF) family member FGD1, thereby promoting F‐actin polymerization in the nucleus.
Minglong Yang +9 more
wiley +1 more source
PAK in Alzheimer disease, Huntington disease and X-linked mental retardation. [PDF]
, 2012 Developmental cognitive deficits including X-linked mental retardation (XLMR) can be caused by mutations in P21-activated kinase 3 (PAK3) that disrupt actin dynamics in dendritic spines.
Cole, Greg M +3 more
core +1 more source
KIF4A drives gliomas growth by transcriptional repression of Rac1/Cdc42 to induce cytoskeletal remodeling in glioma cells [PDF]
, 2022 Hui Zhang +6 more
openalex +1 more source
Advanced Science, EarlyView.It has been demonstrated that, in the bone extracellular matrix (ECM), integrins and growth factor receptors (GFRs) engage in synergistic signaling to guide bone healing and regeneration. This review provides a comprehensive overview of current strategies using ECM‐derived peptides to recreate the cellular microenvironment and harness synergistic ...
Lluís Oliver‐Cervelló +2 more
wiley +1 more source