Results 91 to 100 of about 81,267 (316)

Dbl3 drives Cdc42 signaling at the apical margin to regulate junction position and apical differentiation [PDF]

Epithelial cells develop morphologically characteristic apical domains that are bordered by tight junctions, the apical–lateral border. Cdc42 and its effector complex Par6–atypical protein kinase c (aPKC) regulate multiple steps during epithelial ...
Balda, M.S., Elbediwy, A., Harris, J., Keep, Nicholas H., Matter, K., Munro, P.M.G., Terry, S.J., Zihni, C.   +7 more
core   +1 more source

PAKing up to the endothelium [PDF]

, 2009
Angiogenesis recapitulates the growth of blood vessels that progressively expand and remodel into a highly organized and stereotyped vascular network. During adulthood, endothelial cells that formed the vascular wall retain their plasticity and can be ...
Armelle Le Guelte, Eva Maria, Galan Moya, Julie Gavard   +3 more
core   +6 more sources

CDC42 Deletion Elicits Cerebral Vascular Malformations via Increased MEKK3-Dependent KLF4 Expression

Circulation Research, 2019
Rationale: Aberrant formation of blood vessels precedes a broad spectrum of vascular complications; however, the cellular and molecular events governing vascular malformations are not yet fully understood.
Marco Castro, B. Lavina, Koji Ando, A. Álvarez-Aznar, Abdallah Abu Taha, C. Brakebusch, E. Dejana, C. Betsholtz, K. Gaengel   +8 more
semanticscholar   +1 more source

Discovery of small molecule inhibitors that effectively disrupt IQGAP1-Cdc42 interaction in breast cancer cells

Scientific Reports, 2022
The small GTPase Cdc42 is an integral component of the cytoskeleton, and its dysregulation leads to pathophysiological conditions, such as cancer. Binding of Cdc42 to the scaffold protein IQGAP1 stabilizes Cdc42 in its active form.
Samar Sayedyahossein, Jessica Smith, Elena Barnaeva, Zhigang Li, Jun Choe, Michael Ronzetti, Christopher Dextras, Xin Hu, Juan Marugan, Noel Southall, Bolormaa Baljinnyam, Louise Thines, Andy D. Tran, Marc Ferrer, David B. Sacks   +14 more
doaj   +1 more source

Parameter identification problems in the modelling of cell motility [PDF]

, 2014
We present a novel parameter identification algorithm for the estimation of parameters in models of cell motility using imaging data of migrating cells.
A Friedman, A Mogilner, AM Stuart, AS Ackleh, AS Ackleh, B Onken, Björn Stinner, C Hogea, C Jiang, C Weston, Cathryn Weston, Chandrasekhar Venkataraman, Charles M. Elliott, CT Kelley, D Bray, D Dormann, DW Marquardt, F Haußer, FD Kelly, G Dziuk, G Dziuk, G Dziuk, G Dziuk, Graham Ladds, H Tatebe, I Hecht, IF Sbalzarini, J Alamo Del, J Barrett, J Barrett, J Nocedal, J Satulovsky, JF Monahan, K Deckelnick, K Deckelnick, L Bosgraaf, M Burger, M Herant, M Lombardi, M Mos, M Neilson, MA Dewar, MA Iglesias, MJ Pittet, MR Garvie, O Lakkis, R Lefever, T Drake, TF Chan, V Isakov, Wayne Croft   +50 more
core   +1 more source

Cdc42 and Vesicle Trafficking in Polarized Cells [PDF]

Traffic, 2010
Cdc42, a highly conserved small GTPase of the Rho family, acts as a molecular switch to modulate a wide range of signaling pathways. Vesicle trafficking and cell polarity are two processes Cdc42 is known to regulate. Although the trafficking and polarity machineries are each well understood, how they interact to cross-regulate each other in cell ...
Ulrich Tepass, Kathryn P. Harris
openaire   +3 more sources

DNA Origami‐Cyanine Nanocomplex for Precision Imaging of KRAS‐Mutant Pancreatic Cancer Cells

Advanced Science, EarlyView.
DNA origami‐cyanine (Do‐Cy) nanocomplexes are synthesized to selectively image KRAS‐mutant pancreatic cancer cells in the highly desmoplastic tumors. This study shows that the Do‐Cy nanocomplexes are preferentially internalized by cancer cells over other stroma cells via KRAS‐dependent macropinocytosis.
Hye‐ran Moon, Yancheng Du, Sae Rome Choi, Seongmin Seo, Cih Cheng, Bennett D. Elzey, Jong Hyun Choi, Bumsoo Han   +7 more
wiley   +1 more source

Cdc42 defines apical identity and regulates epithelial morphogenesis by promoting apical recruitment of Par6-aPKC and Crumbs

Development, 2019
Cdc42 regulates epithelial morphogenesis together with the Par complex (Baz/Par3-Par6-aPKC), Crumbs (Crb/CRB3) and Stardust (Sdt/PALS1). However, how these proteins work together and interact during epithelial morphogenesis is not well understood.
Francisca Nunes de Almeida, Rhian F. Walther, Mary T Pressé, E. Vlassaks, F. Pichaud   +4 more
semanticscholar   +1 more source

Unraveling Neurodevelopment: Synergistic Effects of Intrinsic Genetic Programs and Extrinsic Environmental Cues

Advanced Science, EarlyView.
Overview of the regulation of intrinsic and extrinsic signals during neurodevelopment. Intrinsic genetic signals from NSCs, in conjunction with cues from microglia and blood vessels, collaboratively regulate the proliferation of NSCs, their fate determination, synaptogenesis, synaptic pruning, neuronal survival, and death, as well as communication ...
Yanyan Wang, Shukui Zhang, Huiyang Jia, Fen Ji, Jianwei Jiao   +4 more
wiley   +1 more source

Chronic inflammation evoked by pathogenic stimulus during carcinogenesis

4 open, 2019
A pathogenic (biological or chemical) stimulus is the earliest information received by a cell that can result in the disruption of homeostasis with consequent development of disease.
Brücher Björn L.D.M., Jamall Ijaz S.
doaj   +1 more source