Results 91 to 100 of about 39,671 (187)

Hypoxia and the cytoskeleton

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic outlining the activation of hypoxia‐sensitive pathways, the influence of hypoxia and associated pathways on the cytoskeleton, and the impact of these on disease progression. Abstract A highly‐regulated and dynamic cytoskeleton is vital for functional cellular physiology and the maintenance of homeostasis.
Darragh Flood, Cormac T. Taylor
wiley   +1 more source

Cdc42 deletion yielded enamel defects by disrupting mitochondria and producing reactive oxygen species in dental epithelium

Genes and Diseases
Developmental defects of enamel are common due to genetic and environmental factors before and after birth. Cdc42, a Rho family small GTPase, regulates prenatal tooth development in mice.
Jinxuan Zheng, Rongcheng Yu, Yiqi Tang, Sihui Su, Sainan Wang, Chenxi Liao, Xuecong Li, Jiabin Liao, Dongsheng Yu, Tingting Ai, Wei Zhao, Vicky Yau, Chufeng Liu, Liping Wu, Yang Cao   +14 more
doaj   +1 more source

miR-29a Negatively Affects Glucose-Stimulated Insulin Secretion and MIN6 Cell Proliferation via Cdc42/β-Catenin Signaling

International Journal of Endocrinology, 2019
Background. Diabetes is a progressive metabolic disease characterized by hyperglycemia. Functional impairment of islet β cells can occur to varying degrees.
Jing Duan, Xian-Ling Qian, Jun Li, Xing-Hua Xiao, Xiang-Tong Lu, Lin-Chen Lv, Qing-Yun Huang, Wen Ding, Hong-Yan Zhang, Li-Xia Xiong   +9 more
doaj   +1 more source

PTEN regulates colorectal epithelial apoptosis through Cdc42 signalling [PDF]

, 2011
Ravi Kiran Deevi, Aliya Fatehullah, Ishaan Jagan, Mulpuri Nagaraju, Victoria Bingham, F C Campbell   +5 more
openalex   +1 more source

Mechanisms That Prevent Vascular Leakage During Leukocyte Extravasation

Acta Physiologica, Volume 241, Issue 12, December 2025.
ABSTRACT Background Inflammation is the response of the immune system against harmful stimuli in tissues. Leukocyte extravasation or TransEndothelial Migration (TEM) is a crucial step during inflammation, in which leukocytes migrate over the endothelial barrier toward the damaged tissue.
Siem J. de Haan, Jaap D. van Buul
wiley   +1 more source

Rac and Cdc42 team up for platelets [PDF]

, 2013
Joseph E. Aslan, Owen J. T. McCarty
openalex   +1 more source

The Maternal Blood Transcriptome Reflects Changes in Fetal Growth and Is an Accurate Predictor of Birth Weight in Cattle

The FASEB Journal, Volume 39, Issue 21, 15 November 2025.
A bioinformatics approach demonstrated that the maternal blood transcriptome changes throughout gestation, with coexpression clustering indicating interferon responses early on, oxidative phosphorylation mid‐gestation, and immune pathways later in pregnancy.
Laura Thompson, Pim G. van Helvoort, Maurice Duijn, Daphne D. Reinders, Eliza M. Murphy, Michael McDonald, Alan D. Crowe, Stephen T. Butler, Patrick Lonergan, Maria Belen Rabaglino   +9 more
wiley   +1 more source

Mutation in CDC42 Gene Set as a Response Biomarker for Immune Checkpoint Inhibitor Therapy

Cancer Medicine
Background Immune checkpoint inhibitors (ICIs) have achieved great success; however, a subset of patients exhibits no response. Consequently, there is a critical need for reliable predictive biomarkers.
Kun Wang, Yingying Zhang, Zhaoming Su, Bei Wang, Yuanyang Zhou, Xiaochu Tong, Chengying Xie, Xiaomin Luo, Sulin Zhang, Mingyue Zheng   +9 more
doaj   +1 more source

Mechanotransduction in Shaping Immunity: Pathways, Crosstalk, and Pathophysiological Relevance

Advanced Science, Volume 12, Issue 41, November 6, 2025.
This review comprehensively summarizes the role of mechanotransduction in shaping immunity. It details how immune cells respond to biomechanical cues via mechanotransduction cascades and emphasizes the mechanical crosstalks within the immune microenvironment. The emerging significance of mechanoimmunology in both health and diseases is also highlighted.
Ruijiao Yan, Yuyu Li, Shuo Chen, Li Zhu, Chenchen Zhou, Jianwei Chen, Shujuan Zou, Xianglong Han   +7 more
wiley   +1 more source

Identification of miRNA Biomarkers Associated With Staphylococcal Musculoskeletal Infections

Journal of Orthopaedic Research, Volume 43, Issue 11, Page 2055-2065, November 2025.
ABSTRACT Musculoskeletal infections (MSKIs) pose significant challenges in orthopedic surgery. These infections are often caused by Staphylococcus aureus and S. epidermidis. Early diagnosis is crucial, as it allows prompt treatment before the infection becomes chronic and more difficult to manage.
Claudia Siverino, Eric Sumrall, Jorge Úbeda Garrido, Jan Puetzler, Andrej Trampuz, Svetlana Karbysheva, Lei Wang, Robert Geoff Richards, Thomas Fintan Moriarty, Elena Della Bella   +9 more
wiley   +1 more source