Results 11 to 20 of about 27,912 (176)

Cell Division Control Protein 42 Interacts With Hepatitis E Virus Capsid Protein and Participates in Hepatitis E Virus Infection

Frontiers in Microbiology, 2021
Hepatitis E Virus (HEV) causes viral hepatitis in humans worldwide, while a subset of HEV species, avian HEV, causes hepatitis-splenomegaly syndrome in chickens.
Mengnan Fan, Yuhang Luo, Beibei Zhang, Jiaxi Wang, Tianxiang Chen, Baoyuan Liu, Yani Sun, Yuchen Nan, Julian A. Hiscox, Qin Zhao, En-Min Zhou   +10 more
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Discovery of small molecule inhibitors that effectively disrupt IQGAP1-Cdc42 interaction in breast cancer cells

Scientific Reports, 2022
The small GTPase Cdc42 is an integral component of the cytoskeleton, and its dysregulation leads to pathophysiological conditions, such as cancer. Binding of Cdc42 to the scaffold protein IQGAP1 stabilizes Cdc42 in its active form.
Samar Sayedyahossein, Jessica Smith, Elena Barnaeva, Zhigang Li, Jun Choe, Michael Ronzetti, Christopher Dextras, Xin Hu, Juan Marugan, Noel Southall, Bolormaa Baljinnyam, Louise Thines, Andy D. Tran, Marc Ferrer, David B. Sacks   +14 more
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Cdc42/Rac Interactive Binding Containing Effector Proteins in Unicellular Protozoans With Reference to Human Host: Locks of the Rho Signaling

Frontiers in Genetics, 2022
Small GTPases are the key to actin cytoskeleton signaling, which opens the lock of effector proteins to forward the signal downstream in several cellular pathways. Actin cytoskeleton assembly is associated with cell polarity, adhesion, movement and other
Preeti Umarao, Pragyan Parimita Rath, Samudrala Gourinath   +2 more
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Cdc42 functions as a regulatory node for tumour‐derived microvesicle biogenesis

Journal of Extracellular Vesicles, 2021
Tumour‐derived microvesicles (MVs) serve as critical mediators of cell‐to‐cell communication in the tumour microenvironment. So far, the underlying mechanisms of MV biogenesis, especially how key tumorigenesis signals such as abnormal EGF signalling ...
Jing Wang, Xiangjin Zhuang, Kai Su Greene, Ha Si, Marc A. Antonyak, Joseph E. Druso, Kristin F. Wilson, Richard A. Cerione, Qiyu Feng, Hongyang Wang   +9 more
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Rho GTPases and regulation of cell migration and polarization in human corneal epithelial cells. [PDF]

PLoS ONE, 2013
PURPOSE:Epithelial cell migration is required for regeneration of tissues and can be defective in a number of ocular surface diseases. This study aimed to determine the expression pattern of Rho family small G-proteins in human corneal epithelial cells ...
Aihua Hou, Li Xian Toh, Kah Hui Gan, Khee Jin Ryan Lee, Edward Manser, Louis Tong   +5 more
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CDC42-mediated Wnt signaling facilitates odontogenic differentiation of DPCs during tooth root elongation

Stem Cell Research & Therapy, 2023
Background CDC42 is a member of Rho GTPase family, acting as a molecular switch to regulate cytoskeleton organization and junction maturation of epithelium in organ development.
Tao Zhou, Guoqing Chen, Yuchan Xu, Shuning Zhang, Huilin Tang, Tao Qiu, Weihua Guo   +6 more
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Bimodal expression of RHOH during myelomonocytic differentiation: Implications for the expansion of AML differentiation therapy

eJHaem, 2021
RhoH is an unusual member of the Rho family of small GTP‐binding proteins in that it lacks GTPase activity. Since the RhoH protein is constantly bound by GTP, it is constitutively active and controlled predominantly by changes in quantitative expression.
Sylvie Galiègue‐Zouitina, Qiangwei Fu, Céline Carton‐Latreche, Nicolas Poret, Meyling Cheok, Frédéric Leprêtre, Martin Figeac, Bruno Quesnel, Hassiba El Bouazzati, Carl S Shelley   +9 more
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Vav Proteins in Development of the Brain: A Potential Relationship to the Pathogenesis of Congenital Zika Syndrome?

Viruses, 2022
Zika virus (ZIKV) infection during pregnancy can result in a significant impact on the brain and eye of the developing fetus, termed congenital zika syndrome (CZS).
Aidan J. Norbury, Lachlan A. Jolly, Luke P. Kris, Jillian M. Carr   +3 more
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ARHGEF7 (Beta-PIX) acts as guanine nucleotide exchange factor for leucine-rich repeat kinase 2. [PDF]

PLoS ONE, 2010
Mutations within the leucine-rich repeat kinase 2 (LRRK2) gene are a common cause of familial and sporadic Parkinson's disease. The multidomain protein LRRK2 exhibits overall low GTPase and kinase activity in vitro.Here, we show that the rho guanine ...
Karina Haebig, Christian Johannes Gloeckner, Marta Garcia Miralles, Frank Gillardon, Claudia Schulte, Olaf Riess, Marius Ueffing, Saskia Biskup, Michael Bonin   +8 more
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The role of Cdc42 and Gic1 in the regulation of septin filament formation and dissociation

eLife, 2013
Septins are guanine nucleotide-binding proteins that polymerize into filamentous and higher-order structures. Cdc42 and its effector Gic1 are involved in septin recruitment, ring formation and dissociation.
Yashar Sadian, Christos Gatsogiannis, Csilla Patasi, Oliver Hofnagel, Roger S Goody, Marian Farkašovský, Stefan Raunser   +6 more
doaj   +1 more source