Results 11 to 20 of about 25,474 (119)

Enabling systemic identification and functionality profiling for Cdc42 homeostatic modulators [PDF]

Communications Chemistry
Maintaining body homeostasis is the ultimate key to health. There are rich resources of bioactive materials for the functionality of homeostatic modulators (HMs) from both natural and synthetic chemical repertories1–3.
Satyaveni Malasala, Fereshteh Azimian, Yan-Hua Chen, Jeffery L. Twiss, Christi Boykin, Shayan Nik Akhtar, Qun Lu   +6 more
doaj   +2 more sources

The Chlamydia pneumoniae effector SemD exploits its host’s endocytic machinery by structural and functional mimicry [PDF]

Nature Communications
To enter epithelial cells, the obligate intracellular pathogen Chlamydia pneumoniae secretes early effector proteins, which bind to and modulate the host-cell’s plasma membrane and recruit several pivotal endocytic host proteins.
Fabienne Kocher, Violetta Applegate, Jens Reiners, Astrid Port, Dominik Spona, Sebastian Hänsch, Amin Mirzaiebadizi, Mohammad Reza Ahmadian, Sander H. J. Smits, Johannes H. Hegemann, Katja Mölleken   +10 more
doaj   +2 more sources

Cell Division Control Protein 42 Interacts With Hepatitis E Virus Capsid Protein and Participates in Hepatitis E Virus Infection

Frontiers in Microbiology, 2021
Hepatitis E Virus (HEV) causes viral hepatitis in humans worldwide, while a subset of HEV species, avian HEV, causes hepatitis-splenomegaly syndrome in chickens.
Mengnan Fan, Yuhang Luo, Beibei Zhang, Jiaxi Wang, Tianxiang Chen, Baoyuan Liu, Yani Sun, Yuchen Nan, Julian A. Hiscox, Qin Zhao, En-Min Zhou   +10 more
doaj   +1 more source

Discovery of small molecule inhibitors that effectively disrupt IQGAP1-Cdc42 interaction in breast cancer cells

Scientific Reports, 2022
The small GTPase Cdc42 is an integral component of the cytoskeleton, and its dysregulation leads to pathophysiological conditions, such as cancer. Binding of Cdc42 to the scaffold protein IQGAP1 stabilizes Cdc42 in its active form.
Samar Sayedyahossein, Jessica Smith, Elena Barnaeva, Zhigang Li, Jun Choe, Michael Ronzetti, Christopher Dextras, Xin Hu, Juan Marugan, Noel Southall, Bolormaa Baljinnyam, Louise Thines, Andy D. Tran, Marc Ferrer, David B. Sacks   +14 more
doaj   +1 more source

Cdc42/Rac Interactive Binding Containing Effector Proteins in Unicellular Protozoans With Reference to Human Host: Locks of the Rho Signaling

Frontiers in Genetics, 2022
Small GTPases are the key to actin cytoskeleton signaling, which opens the lock of effector proteins to forward the signal downstream in several cellular pathways. Actin cytoskeleton assembly is associated with cell polarity, adhesion, movement and other
Preeti Umarao, Pragyan Parimita Rath, Samudrala Gourinath   +2 more
doaj   +1 more source

Cdc42 functions as a regulatory node for tumour‐derived microvesicle biogenesis

Journal of Extracellular Vesicles, 2021
Tumour‐derived microvesicles (MVs) serve as critical mediators of cell‐to‐cell communication in the tumour microenvironment. So far, the underlying mechanisms of MV biogenesis, especially how key tumorigenesis signals such as abnormal EGF signalling ...
Jing Wang, Xiangjin Zhuang, Kai Su Greene, Ha Si, Marc A. Antonyak, Joseph E. Druso, Kristin F. Wilson, Richard A. Cerione, Qiyu Feng, Hongyang Wang   +9 more
doaj   +1 more source

Rho GTPases and regulation of cell migration and polarization in human corneal epithelial cells. [PDF]

PLoS ONE, 2013
PURPOSE:Epithelial cell migration is required for regeneration of tissues and can be defective in a number of ocular surface diseases. This study aimed to determine the expression pattern of Rho family small G-proteins in human corneal epithelial cells ...
Aihua Hou, Li Xian Toh, Kah Hui Gan, Khee Jin Ryan Lee, Edward Manser, Louis Tong   +5 more
doaj   +1 more source

Energetic constraints on filament mediated cell polarization [PDF]

, 2021
Cell polarization underlies many cellular processes, such as differentiation, migration, and budding. Many living cells, such as budding yeast and fission yeast, use cytoskeletal structures to actively transport proteins to one location on the membrane and create a high density spot of membrane-bound proteins.
arxiv   +1 more source

CDC42-mediated Wnt signaling facilitates odontogenic differentiation of DPCs during tooth root elongation

Stem Cell Research & Therapy, 2023
Background CDC42 is a member of Rho GTPase family, acting as a molecular switch to regulate cytoskeleton organization and junction maturation of epithelium in organ development.
Tao Zhou, Guoqing Chen, Yuchan Xu, Shuning Zhang, Huilin Tang, Tao Qiu, Weihua Guo   +6 more
doaj   +1 more source

Bimodal expression of RHOH during myelomonocytic differentiation: Implications for the expansion of AML differentiation therapy

eJHaem, 2021
RhoH is an unusual member of the Rho family of small GTP‐binding proteins in that it lacks GTPase activity. Since the RhoH protein is constantly bound by GTP, it is constitutively active and controlled predominantly by changes in quantitative expression.
Sylvie Galiègue‐Zouitina, Qiangwei Fu, Céline Carton‐Latreche, Nicolas Poret, Meyling Cheok, Frédéric Leprêtre, Martin Figeac, Bruno Quesnel, Hassiba El Bouazzati, Carl S Shelley   +9 more
doaj   +1 more source