Results 21 to 30 of about 25,474 (119)
Viruses, 2022 Zika virus (ZIKV) infection during pregnancy can result in a significant impact on the brain and eye of the developing fetus, termed congenital zika syndrome (CZS).
Aidan J. Norbury +3 more
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ARHGEF7 (Beta-PIX) acts as guanine nucleotide exchange factor for leucine-rich repeat kinase 2. [PDF]
PLoS ONE, 2010 Mutations within the leucine-rich repeat kinase 2 (LRRK2) gene are a common cause of familial and sporadic Parkinson's disease. The multidomain protein LRRK2 exhibits overall low GTPase and kinase activity in vitro.Here, we show that the rho guanine ...
Karina Haebig +8 more
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The role of Cdc42 and Gic1 in the regulation of septin filament formation and dissociation
eLife, 2013 Septins are guanine nucleotide-binding proteins that polymerize into filamentous and higher-order structures. Cdc42 and its effector Gic1 are involved in septin recruitment, ring formation and dissociation.
Yashar Sadian +6 more
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Molecules and mechanisms that regulate multipolar migration in the intermediate zone
Frontiers in Cellular Neuroscience, 2014 Most neurons migrate with an elongated, bipolar morphology, extending a long leading process that explores the environment. However, when immature projection neurons enter the intermediate zone of the neocortex they become multipolar.
Jonathan A Cooper
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Cell Communication and Signaling, 2011 Background Host cell invasion by the foodborne pathogen Campylobacter jejuni is considered as one of the primary reasons of gut tissue damage, however, mechanisms and key factors involved in this process are widely unclear. It was reported that small Rho
Krause-Gruszczynska Malgorzata +7 more
doaj +1 more source
Topological and functional properties of the small GTPases protein interaction network. [PDF]
PLoS ONE, 2012 Small GTP binding proteins of the Ras superfamily (Ras, Rho, Rab, Arf, and Ran) regulate key cellular processes such as signal transduction, cell proliferation, cell motility, and vesicle transport.
Anna Delprato
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, 2023 <p>Supplementary Figure S6 shows the inhibition of Rac1B, Rac1, and Rac1 P29S by MBQ-167</p>
Suranganie Dharmawardhane +9 more
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Signaling from the Small GTP-binding Proteins Rac1 and Cdc42 to the c-Jun N-terminal Kinase/Stress-activated Protein Kinase Pathway [PDF]
Journal of Biological Chemistry, 1996 Certain small GTP-binding proteins control the enzymatic activity of a family of closely related serine-threonine kinases known as mitogen-activated protein kinases (MAPKs). In turn, these MAPKs, such as p44(mapk) and p42(mapk), referred to herein as MAPKs, and stress-activated protein kinases, also termed c-Jun N-terminal kinases (JNKs), phosphorylate
J. Silvio Gutkind +5 more
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Spots, strips, and spiral waves in models for static and motile cells [PDF]
J. Math. Biol. 82, 28 (2021), 2019 The polarization and motility of eukaryotic cells depends on assembly and contraction of the actin cytoskeleton and its regulation by proteins called GTPases. The activity of GTPases causes assembly of filamentous actin (by GTPases Cdc42, Rac), resulting in protrusion of the cell edge.
arxiv +1 more source
, 2023 <p>Supplementary Figure S5 shows the effect of MBQ compounds on Rac activation in attached and detached cells.</p>
Suranganie Dharmawardhane +9 more
openaire +1 more source