Role of Rac GTPase activating proteins in regulation of NADPH oxidase in human neutrophils [PDF]
, 2014 Precise spatiotemporal regulation of O2 --generating NADPH oxidases (Nox) is a vital requirement. In the case of Nox1-3, which depend on the small GTPase Rac, acceleration of GTP hydrolysis by GTPase activating protein (GAP) could represent a feasible ...
Abo +68 more
core +1 more source
Preservation Time on Ice Impacts Global Gene Expression in Oyster Spat
Aquaculture, Fish and Fisheries, Volume 5, Issue 5, October 2025.ABSTRACT The pearling industry is one of Australia's most valuable and iconic industries, creating significant economic and employment opportunities across Northern Australia. To improve our understanding of the relationship between the silver‐lipped pearl oyster and its biotic and abiotic environment using transcriptomics, oyster spat are collected ...
Anita Alice Severn‐Ellis +2 more
wiley +1 more source
NLRP4E regulates actin cap formation through SRC and CDC42 during oocyte meiosis
Cellular & Molecular Biology LettersBackground Members of the nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing (NLRP) family regulate various physiological and pathological processes. However, none have been shown to regulate actin cap formation or
Li-Ya Shi +15 more
doaj +1 more source
Role of competition between polarity sites in establishing a unique front [PDF]
, 2015 Polarity establishment in many cells is thought to occur via positive feedback that reinforces even tiny asymmetries in polarity protein distribution. Cdc42 and related GTPases are activated and accumulate in a patch of the cortex that defines the front ...
Chiou, Jian-Geng +8 more
core +3 more sources
Microcirculation, Volume 32, Issue 7, October 2025.ABSTRACT Objective Microvascular hyperpermeability is a serious complication that occurs from hemorrhagic shock and resuscitation (HSR), especially when combined with acute alcohol intoxication (AAI). We tested the hypothesis that administration of Apolipoprotein M (ApoM), a lipocalin that normally resides in plasma high‐density lipoproteins (HDL) and ...
Mengmeng Chang, Jerome W. Breslin
wiley +1 more source
Spontaneous cell polarization: Feedback control of Cdc42 GTPase breaks cellular symmetry. [PDF]
, 2015 Spontaneous polarization without spatial cues, or symmetry breaking, is a fundamental problem of spatial organization in biological systems. This question has been extensively studied using yeast models, which revealed the central role of the small ...
Martin, S.G.
core +2 more sources
Citron binds to PSD-95 at glutamatergic synapses on inhibitory neurons in the hippocampus [PDF]
, 1999 Synaptic NMDA-type glutamate receptors are anchored to the second of three PDZ (PSD-95/Discs large/ZO-1) domains in the postsynaptic density (PSD) protein PSD-95.
Apperson, Michelle +3 more
core +1 more source
Dynamic cofilin phosphorylation in the control of lamellipodial actin homeostasis [PDF]
, 2007 During animal cell chemotaxis, signalling at the plasma membrane induces actin polymerisation to drive forward cell movement. Since the cellular pool of actin is limited, efficient protrusion formation also requires the coordinated disassembly of pre ...
Baum, B +4 more
core
Atypical Protein Kinases Cλ and -ζ Associate with the GTP-Binding Protein Cdc42 and Mediate Stress Fiber Loss [PDF]
, 2000 Matthew P. Coghlan +2 more
openalex +1 more source
Characterization of Novel Derivatives of MBQ-167, an Inhibitor of the GTP-binding Proteins Rac/Cdc42 [PDF]
, 2022 Julia I. Medina +9 more
openalex +1 more source