Results 131 to 140 of about 138,770 (367)

Cancer therapy by cyclin-dependent kinase inhibitors (CDKIs)

EXCLI Journal : Experimental and Clinical Sciences
A major characteristic of cancer is dysregulated cell division, which results in aberrant growth of cells. Consequently, medicinal targets that prevent cell division would be useful in the fight against cancer. The primary regulator of proliferation is a
Ali Hassanzadeh, Navid Shomali, Amin Kamrani, Mohammad Sadegh Soltani-Zangbar, Hadi Nasiri, Morteza Akbari   +5 more
doaj   +1 more source

Cell Cycle Control by a Minimal Cdk Network

PLoS Comput. Biol., 2015
In present-day eukaryotes, the cell division cycle is controlled by a complex network of interacting proteins, including members of the cyclin and cyclin-dependent protein kinase (Cdk) families, and the Anaphase Promoting Complex (APC).
C. Gérard, J. Tyson, D. Coudreuse, B. Novák   +3 more
semanticscholar   +1 more source

Immuno‐haemostatic dysregulation in heart failure with preserved ejection fraction

ESC Heart Failure, EarlyView.
Abstract Aims Heart failure with preserved ejection fraction (HFpEF) is a complex condition with partially unclear pathophysiology, in which systemic inflammation is a central contributor to changes in cardiac structure and function. The contribution of non‐traditional immune effectors—such as platelets and coagulation—remains underexplored in HFpEF ...
Giorgia D'Italia, Daniëlle M. Coenen, Titus P. Lemmens, Lloyd Brandts, Simone J. H. Wielders, Magdolna Nagy, Sanne G. J. Mourmans, Anouk Achten, Ahmad Al‐Abadi, Jerremy Weerts, Arantxa Barandiaran Aizpurua, Vanessa van Empel, Blanche Schroen, Judith M. E. M. Cosemans   +13 more
wiley   +1 more source

The Chemistry Development Kit (CDK): An Open-Source Java Library for Chemo-and Bioinformatics

Journal of chemical information and computer sciences, 2003
The Chemistry Development Kit (CDK) is a freely available open-source Java library for Structural Chemo-and Bioinformatics. Its architecture and capabilities as well as the development as an open-source project by a team of international collaborators ...
C. Steinbeck, Yongquan Han, S. Kuhn, Oliver Horlacher, Edgar Luttmann, Egon Willighagen   +5 more
semanticscholar   +1 more source

DMAPO/Boc2O‐Mediated One‐Pot Direct N‐Acylation of Sulfoximines with Carboxylic Acids

European Journal of Organic Chemistry, Accepted Article.
This report describes a general and simple method for the one‐pot direct N‐acylation of sulfoximines with carboxylic acids using our previously developed 4‐(N,N‐dimethylamino)pyridine N‐oxide (DMAPO)/di‐tert‐butyl dicarbonate (Boc2O) system. The method can be performed under mild low‐temperature reaction conditions and has a wide substrate scope.
Atsushi Umehara, Sukenao Kawai, Makoto Sasaki   +2 more
wiley   +1 more source

The Interaction of CtIP and Nbs1 Connects CDK and ATM to Regulate HR–Mediated Double-Strand Break Repair

PLoS Genetics, 2013
CtIP plays an important role in homologous recombination (HR)–mediated DNA double-stranded break (DSB) repair and interacts with Nbs1 and BRCA1, which are linked to Nijmegen breakage syndrome (NBS) and familial breast cancer, respectively.
Hailong Wang, Linda Z. Shi, Catherine C L Wong, Xuemei Han, Patty Yi-Hwa Hwang, L. Truong, Qingyuan Zhu, Zhengping Shao, David J. Chen, M. Berns, J. Yates, Longchuan Chen, Xiaohua Wu   +12 more
semanticscholar   +1 more source

From quiescence to proliferation : Cdk oscillations drive the mammalian cell cycle

Frontiers in Physiology, 2012
We recently proposed a detailed model describing the dynamics of the network of cyclin-dependent kinases (Cdks) driving the mammalian cell cycle [Gérard, C. and Goldbeter, A. (2009).
Claude eGérard, Albert eGoldbeter
doaj   +1 more source

Phylogenetic analysis of CDK and cyclin proteins in premetazoan lineages

BMC Evolutionary Biology, 2014
BackgroundThe molecular history of animal evolution from single-celled ancestors remains a major question in biology, and little is known regarding the evolution of cell cycle regulation during animal emergence.
Lihuan Cao, Fang Chen, Xian-mei Yang, Weijin Xu, Jun Xie, Long Yu   +5 more
semanticscholar   +1 more source

Somatic cell reprogramming for Parkinson's disease treatment

Ibrain, Volume 11, Issue 1, Page 59-73, Spring 2025.
The fundamental purpose of cell reprogramming to treat Parkinson's disease is to generate dopaminergic neurons (DAN) and do transplantation. There are two ways to accomplish this. One method is to induce cells into induced DA neurons (iDAN) directly or to induce cells into induced pluripotent stem cells and ultimately into iDAN in vitro. Another option
Xiaozhuo Li, Kevin Fang, Fengping Wang
wiley   +1 more source

Highlights of the Latest Advances in Research on CDK Inhibitors

Cancers, 2014
Uncontrolled proliferation is the hallmark of cancer and other proliferative disorders and abnormal cell cycle regulation is, therefore, common in these diseases.
J. Cicenas, Karthik Kalyan, Aleksandras Sorokinas, Asta Jatulyte, D. Valiūnas, A. Kaupinis, M. Valius   +6 more
semanticscholar   +1 more source