Results 141 to 150 of about 138,770 (367)
Targeting the Menin–KMT2A interaction in leukemia: Lessons learned and future directions
International Journal of Cancer, EarlyView.Abstract Chromosomal rearrangements involving the Mixed Lineage Leukemia gene (MLL1, KMT2A) are defining a genetically distinct subset in about 10% of human acute leukemias. Translocations involving the KMT2A‐locus at chromosome 11q23 are resulting in the formation of a chimeric oncogene, where the N‐terminal part of KMT2A is fused to a variety of ...
Florian Perner +3 more
wiley +1 more source
Kip/Cip and Ink4 Cdk inhibitors cooperate to induce cell cycle arrest in response to TGF-beta.
Genes & Development, 1995 G1 progression in mammalian cells requires the activity of the cyclin D-dependent kinases Cdk4 and/or Cdk6 and the cyclin E-dependent kinase Cdk2. Proliferating Mv1Lu mink lung epithelial cells and human keratinocytes contain high levels of the universal
Inga Reynisd +3 more
semanticscholar +1 more source
, 2010 An OpenTox Virtual Seminar about Bioclipse - Life Science Application and Ontology Development in Cheminformatics and Bioinformatics.
openaire +2 more sources
International Journal of Cancer, EarlyView.What's New? Multiple genetic polymorphisms characteristic of type 2 diabetes (T2D) have been associated with unfavorable prognostic outcomes in individuals with both T2D and metastatic colorectal cancer. This study evaluated the impact of T2D genetic polymorphisms on metastatic colon cancer prognosis in a cohort of non‐diabetic patients.
Raffaella Ruggiero +11 more
wiley +1 more source
Cell Cycle Control in Eukaryotes: a BioSpi model [PDF]
, 2003 This paper presents a stochastic model of the cell cycle control in eukaryotes. The framework used is based on stochastic process algebras for mobile systems. The automatic tool used in the simulation is the BioSpi. We compare our approach with classical
Lecca, Paola, Priami, Corrado
core
Calpain Proteases and the Evolving Signaling Network in Insect Embryonic Patterning
Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, EarlyView.Insect embryonic Dorsal‐Ventral (DV) patterning relies on the BMP and Toll pathways to different extents. Calcium‐dependent cystein proteases of the Calpain family also exert an important function to pattern the DV axis. In Drosophila, Calpain A cleaves the Cactus/IkappaB inhibitor and modifies Toll signals in ventral regions of the embryo. In Rhodnius
Alison Julio, Helena Araujo
wiley +1 more source
Risk Analysis Index Versus Modified Frailty Index: Outcomes After Otolaryngologic Surgery
The Laryngoscope, EarlyView.RAI and MFI‐5 are two frailty scoring systems used for perioperative risk assessment in multiple surgical specialties. This study shows that RAI outperformed MFI‐5 in predicting postoperative outcomes in patients undergoing otolaryngologic surgeries.
Lauran K. Evans +6 more
wiley +1 more source
Regulation of the human WEE1Hu CDK tyrosine 15-kinase during the cell cycle. [PDF]
, 1995 Nobumoto Watanabe +2 more
openalex +1 more source
Lipids, EarlyView.Low‐dose atorvastatin combined with ezetimibe achieves superior LDL‐C reduction (44.8%) compared with equivalent or higher‐dose statin monotherapy in Korean patients, presenting a more effective and safer therapeutic strategy potentially applicable to broader Asian populations.
Tae Oh Kim +19 more
wiley +1 more source
The Phosphatase Cdc14 Triggers Mitotic Exit by Reversal of Cdk-Dependent Phosphorylation [PDF]
, 1998 Rosella Visintin +5 more
openalex +1 more source