Results 11 to 20 of about 125,522 (281)
The Role Of Time Delays, Slow Processes And Chaos In Modulating The Cell-Cycle Clock
Mathematical Biosciences and Engineering, 2005 The regulation of the cell cycle clock is examined using a theoretical model for the embryonic cell cycle, where the clock is described as a single-limit cycle [1].
E.V. Presnov, Z. Agur
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Direct regulation of Treslin by cyclin-dependent kinase is essential for the onset of DNA replication [PDF]
, 2011 Treslin, a TopBP1-interacting protein, is necessary for deoxyribonucleic acid (DNA) replication in vertebrates. Association between Treslin and TopBP1 requires cyclin-dependent kinase (Cdk) activity in Xenopus laevis egg extracts.
Dunphy, William G. +3 more
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BMC Genomics, 2021 Background Cyclin-dependent kinases (CDKs) are protein kinases regulating important cellular processes such as cell cycle and transcription. Many CDK genes also play a critical role during adipogenic differentiation, but the role of CDK gene family in ...
Cuili Pan +8 more
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How to halve ploidy : lessons from budding yeast meiosis [PDF]
, 2012 Maintenance of ploidy in sexually reproducing organisms requires a specialized form of cell division called meiosis that generates genetically diverse haploid gametes from diploid germ cells.
Arumugam, Prakash +2 more
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Studia Mythologica Slavica, 2019 In 1973, Ivanov and Toporov developed an attempted reconstruction of the presumably central theme of ancient Slavic mythology, viz. the cosmic battle between the thunder-god Perunъ and his adversary Volosъ the cattle god, modelled after the analogous ...
Milorad Ivanković
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Cyclin E and Cdk2 control GLD-1, the mitosis/meiosis decision, and germline stem cells in Caenorhabditis elegans. [PDF]
PLoS Genetics, 2011 Coordination of the cell cycle with developmental events is crucial for generation of tissues during development and their maintenance in adults. Defects in that coordination can shift the balance of cell fates with devastating clinical effects.
Johan Jeong +2 more
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Proteogenomic characterization of cholangiocarcinoma
Hepatology, EarlyView., 2022 Proteogenomic characterization of cholangiocarcinoma with therapeutic strategies Abstract Background and Aims Cholangiocarcinoma (CCA) is a highly heterogeneous cancer with limited understanding and few effective therapeutic approaches. We aimed at providing a proteogenomic CCA characterization to inform biological processes and treatment ...
Mengjie Deng +18 more
wiley +1 more source
Cyclin-Dependent Kinase Inhibitors and Their Therapeutic Potential in Colorectal Cancer Treatment
Frontiers in Pharmacology, 2021 Cyclin-dependent kinases (CDKs) are key players in cell cycle regulation. So far, more than ten CDKs have been described. Their direct interaction with cyclins allow progression through G1 phase, transitions to S and G2 phase and finally through mitosis (
Oana-Maria Thoma +6 more
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Cascades of multisite phosphorylation control Sic1 destruction at the onset of S phase. [PDF]
, 2011 Multisite phosphorylation of proteins has been proposed to transform a graded protein kinase signal into an ultrasensitive switch-like response. Although many multiphosphorylated targets have been identified, the dynamics and sequence of individual ...
Balog, Eva Rose M +8 more
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An RB insensitive to CDK regulation
Molecular & Cellular Oncology, 2017 The N-term phosphorylation of Retinoblastoma (RB) by the p38 stress-activated protein kinase (SAPK) makes RB insensitive to cyclin-dependent kinase (CDK)-Cyclin inhibition, which enhances the transcriptional repression of E2F-driven promoters and delays ...
Manel Joaquin +2 more
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