Results 11 to 20 of about 137,554 (368)
Multisite phosphorylation code of CDK [PDF]
Nature Structural & Molecular Biology, 2019 The quantitative model of cyclin-dependent kinase (CDK) function states that cyclins temporally order cell cycle events at different CDK activity levels, or thresholds.
Mihkel Örd +7 more
semanticscholar +4 more sources
An RB insensitive to CDK regulation [PDF]
Molecular & Cellular Oncology, 2017 The N-term phosphorylation of Retinoblastoma (RB) by the p38 stress-activated protein kinase (SAPK) makes RB insensitive to cyclin-dependent kinase (CDK)-Cyclin inhibition, which enhances the transcriptional repression of E2F-driven promoters and delays ...
Manel Joaquin +2 more
doaj +4 more sources
Functional Versatility of the CDK Inhibitor p57Kip2 [PDF]
Frontiers in Cell and Developmental Biology, 2020 The cyclin/CDK inhibitor p57Kip2 belongs to the Cip/Kip family, with p21Cip1 and p27Kip1, and is the least studied member of the family. Unlike the other family members, p57Kip2 has a unique role during embryogenesis and is the only CDK inhibitor ...
Justine Creff, A. Besson
semanticscholar +6 more sources
CDK signaling via nonconventional CDK phosphorylation sites
Molecular Biology of the Cell, 2023 Since the discovery of cyclin-dependent kinases (CDKs), it has been perceived as a dogma that CDK signaling in the cell cycle is mediated via targeting the CDK consensus sites: the optimal and the minimal motifs S/T-P-x-K/R and S/T-P, respectively.
Valk, Ervin +3 more
openaire +2 more sources
The origin of CDK regulation [PDF]
Nature Cell Biology, 2001 The initiation of DNA replication is restrained by Cip/Kip proteins that inhibit Cdk2. Degradation of Xenopus Xic1, a Kip1 orthologue, is dependent on its recruitment to replication origins. This ensures that activation of Cdk2 and (subsequent initiation of replication) is co-ordinately regulated at, and localised to, replication origins.
Li, Anatoliy, Blow, J. Julian
openaire +4 more sources
CDK control pathways integrate cell size and ploidy information to control cell division
eLife, 2021 Maintenance of cell size homeostasis is a property that is conserved throughout eukaryotes. Cell size homeostasis is brought about by the co-ordination of cell division with cell growth and requires restriction of smaller cells from undergoing mitosis ...
James Oliver Patterson +3 more
doaj +1 more source
The CDK inhibitor CR8 acts as a molecular glue degrader that depletes cyclin K
Nature, 2020 Molecular glue compounds induce protein–protein interactions that, in the context of a ubiquitin ligase, lead to protein degradation1. Unlike traditional enzyme inhibitors, these molecular glue degraders act substoichiometrically to catalyse the rapid ...
Mikołaj Słabicki +23 more
semanticscholar +1 more source
CDK-Independent and PCNA-Dependent Functions of p21 in DNA Replication
Genes, 2020 p21Waf/CIP1 is a small unstructured protein that binds and inactivates cyclin-dependent kinases (CDKs). To this end, p21 levels increase following the activation of the p53 tumor suppressor.
S. Mansilla +4 more
semanticscholar +1 more source
CDK1/2/5 blockade: killing two birds with one stone
OncoImmunology, 2021 Pancreatic ductal adenocarcinoma (PDAC) is an immune resistant tumor. We recently demonstrated that inhibiting CDK1/2/5 by dinaciclib not only blocks immune checkpoint expression, but also triggers histone-dependent immunogenic cell death.
Jiao Liu, Rui Kang, Daolin Tang
doaj +1 more source
Quantifying CDK inhibitor selectivity in live cells
Nature Communications, 2020 Concerted multidisciplinary efforts have led to the development of Cyclin-Dependent Kinase inhibitors (CDKi’s) as small molecule drugs and chemical probes of intracellular CDK function.
C. Wells +16 more
semanticscholar +1 more source