Results 231 to 240 of about 138,770 (367)

Transcriptional repression of SOX2 by p53 in cancer cells regulates cell identity and migration

International Journal of Cancer, Volume 157, Issue 5, Page 980-992, 1 September 2025.
What's new? SOX2 is one of the key developmental genes with a reported altered expression in many tumors. The mechanisms underlying SOX2 regulation in cancer, however, remain elusive. This study shows that TP53 transcriptionally regulates SOX2 through binding to its promoter and the SRR2 enhancer.
Patricia Lado‐Fernández, Jéssica M. Vilas, Tânia Fernandes, Carmen Carneiro, Sabela Da Silva‐Álvarez, Valentín Estévez‐Souto, Pablo Pedrosa, Miguel González‐Barcia, Luis E. Abatti, Jennifer A. Mitchell, Carmen Rivas, Gema Moreno‐Bueno, Anxo Vidal, Manuel Collado   +13 more
wiley   +1 more source

Induction of the Cdk inhibitor p21 by LY83583 inhibits tumor cell proliferation in a p53-independent manner [PDF]

, 2002
Dimitri Lodygin, Antje Menssen, Heiko Hermeking   +2 more
openalex   +2 more sources

Effect of pretreatment lab abnormalities on the time-to-treatment discontinuation and overall survival of metastatic breast cancer patients receiving CDK 4/6i, PI3Ki, and/or mTORi. [PDF]

Breast Cancer Res Treat
Franks J, Azuero A, Kenzik K, Jahan N, Fowler M, Griffin R, Rocque G.   +6 more
europepmc   +1 more source

Mechanistic Interactions Driving Nucleus Pulposus Cell Senescence in Intervertebral Disc Degeneration: A Multi‐Axial Perspective of Mechanical, Immune, and Metabolic Pathways

JOR SPINE, Volume 8, Issue 3, September 2025.
The senescence of NPCs is at the heart of the pathogenesis of intervertebral disc degeneration (IVDD), which causes low back discomfort. ABSTRACT Background The senescence of nucleus pulposus cells (NPCs) at the heart of the pathogenesis of intervertebral disc degeneration (IVDD), which causes low back pain.
Yunbo Yang, Haoming Li, Junhui Zuo, Fei Lei   +3 more
wiley   +1 more source

Climatic droplet keratopathy in both eyes: A case report. [PDF]

Medicine (Baltimore)
Ai Shan ABDSTE, Lei DK, Zhou Y, Li X.
europepmc   +1 more source

The Hsp90β Isoform: An Attractive Target for Drug Development

Medicinal Research Reviews, Volume 45, Issue 5, Page 1452-1465, September 2025.
ABSTRACT The beta isoform of 90 kDa heat shock protein (Hsp90β) plays a critical role in maintaining cellular proteostasis by assisting in the folding and refolding of proteins, which is essential for both normal cellular function and stress response.
Subhabrata Chaudhury, Terin D'Amico, Brian S. J. Blagg   +2 more
wiley   +1 more source

Study protocol to assess clinical outcomes of breast cancer and its relationship with access to healthcare in Brazil-BREAST trial (BRaziLian outcomE for metAStatic breasT cancer): a prospective observational study in HER2-negative/hormone receptor-positive metastatic disease. [PDF]

BMJ Open
Sanvido VM, Pontes LB, Machado RH, Gomes JO, Barbante LG, Nicola ML, Tokunaga SM, Miranda TA, Laranjeira LN, Negrelli KL, Valeis N, Moutinho MSP, Helber HA, Sá RDS, Kawano-Dourado L, Cavalcanti AB, Nazário ACP.   +16 more
europepmc   +1 more source

Activation of caspase-3 by cysteamine: Possible mechanism of the CDK inhibitor p21 cleavage in duodenal ulceration

, 2000
Tetyana Khomenko, Sándor Szabó, Masashi Yoshida, Xiaoming Deng, Warner H. Florsheim, Hiroko Matsumoto   +5 more
openalex   +1 more source

Essential function of histone deacetylase 1 in proliferation control and CDK inhibitor repression [PDF]

, 2002
G. Lagger, Dónal O’Carroll, Martina Rembold, Harald Khier, Julia Tischler, Georg Weitzer, Bernd Schuettengruber, Christoph Hauser, Reinhard Brunmeir, Thomas Jenuwein, Christian Seiser   +10 more
openalex   +1 more source

Transforming Growth Factor‐Beta Signaling in Cancer: Therapeutic Implications, Challenges, and Pathways to Progress

MedComm – Oncology, Volume 4, Issue 3, September 2025.
TGF‐β inhibition is emerging as a promising cancer therapy, yet translating laboratory success to bedside implementation has suffered significant setbacks. The associated challenges include adverse drug reactions, inadequate predictive models, and activation of alternative signaling pathways.
Faizah A. Alabi, Izuchukwu F. Okpalanwaka, Adenike Oyegbesan, Ebenezar Okoyeocha, Mariam Oladejo, Sikiru O. Imodoye   +5 more
wiley   +1 more source