Опухоли женской репродуктивной системы, 2016 Current standards of treatment of endocrine-dependent cancers (breast cancer (BC), prostate cancer) imply sequential use of endocrine therapy and cytotoxic agents: it is believed, that steroid hormone antagonists cease the division of transformed cells ...
E. N. Imyanitov
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Functional characterization of the diatom cyclin-dependent kinase A2 as a mitotic regulator reveals plant-like properties in a non-green lineage [PDF]
, 2015 Background: Cyclin-dependent kinases (CDKs) are crucial regulators of cell cycle progression in eukaryotes. The diatom CDKA2 was originally assigned to the classical A-type CDKs, but its cell cycle phase-specific transcription at the G2-to-M phase ...
Bowler, Chris +4 more
core +2 more sources
Biological Role of CDK 11 and 12 in Cell Cycle and its Function in Tumorigenesis
Pakistan Journal of Medicine and Dentistry, 2020 Uninhibited proliferation and abnormal cell cycle regulation are the hallmarks of cancer. The main role of cyclin dependent kinases is to regulate the cell cycle and cell proliferation. These protein kinases are frequently down regulated or up regulated
Danish Mohammad +3 more
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The p53-MDM2 network: from oscillations to apoptosis [PDF]
, 2007 The p53 protein is well-known for its tumour suppressor function. The p53-MDM2 negative feedback loop constitutes the core module of a network of regulatory interactions activated under cellular stress.
Bose, Indrani, Ghosh, Bhaswar
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Clinical approach for diagnosing chronic kidney disease based on a series of cases in dogs [PDF]
Arquivo Brasileiro de Medicina Veterinária e ZootecniaChronic kidney disease (CDK) is the condition most frequently diagnosed in nephrology in dogs. CDK is progressive and irreversible, but the patient can be treated to decrease the rate of progression and improve the quality of life.
A.M.F.R. Tovar +3 more
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Meiotic nuclear divisions in budding yeast require PP2ACdc55-mediated antagonism of Net1 phosphorylation by Cdk [PDF]
, 2011 During meiosis, one round of deoxyribonucleic acid replication is followed by two rounds of nuclear division. In Saccharomyces cerevisiae, activation of the Cdc14 early anaphase release (FEAR) network is required for exit from meiosis I but does not lead
Arumugam, Prakash +5 more
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CDK-1 Inhibition in G2 Stabilizes Kinetochore-Microtubules in the following Mitosis. [PDF]
PLoS ONE, 2016 Cell proliferation is driven by cyclical activation of cyclin-dependent kinases (CDKs), which produce distinct biochemical cell cycle phases. Mitosis (M phase) is orchestrated by CDK-1, complexed with mitotic cyclins.
A Sophia Gayek, Ryoma Ohi
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Efficient Algorithms for Membership in Boolean Hierarchies of Regular Languages [PDF]
, 2007 The purpose of this paper is to provide efficient algorithms that decide membership for classes of several Boolean hierarchies for which efficiency (or even decidability) were previously not known. We develop new forbidden-chain characterizations for the
Glasser, Christian +2 more
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Whi5 regulation by site specific CDK-phosphorylation in Saccharomyces cerevisiae.
PLoS ONE, 2009 The Whi5 transcriptional repressor is a negative regulator of G1 cell cycle progression in Saccharomyces cerevisiae and is functionally equivalent to the Retinoblastoma (Rb) tumor suppressor protein in mammals. In early G1, Whi5 binds to and inhibits SBF
Michelle V Wagner +5 more
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Visualizing the metazoan proliferation-quiescence decision in vivo
eLife, 2020 Cell proliferation and quiescence are intimately coordinated during metazoan development. Here, we adapt a cyclin-dependent kinase (CDK) sensor to uncouple these key events of the cell cycle in Caenorhabditis elegans and zebrafish through live-cell ...
Rebecca C Adikes +20 more
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