Results 31 to 40 of about 137,554 (368)

Cyclin E and Cdk2 control GLD-1, the mitosis/meiosis decision, and germline stem cells in Caenorhabditis elegans. [PDF]

PLoS Genetics, 2011
Coordination of the cell cycle with developmental events is crucial for generation of tissues during development and their maintenance in adults. Defects in that coordination can shift the balance of cell fates with devastating clinical effects.
Johan Jeong, Jamie M Verheyden, Judith Kimble   +2 more
doaj   +1 more source

Transcriptional CDKs in the spotlight [PDF]

Transcription, 2019
At every active gene in any genome, there is a transcription cycle, defined as the collective set of biochemical reactions that control RNA polymerase activity, from promoter binding to polymerase ...
openaire   +3 more sources

The cryoelectron microscopy structure of the human CDK-activating kinase

Proceedings of the National Academy of Sciences of the United States of America, 2020
Significance Control of gene expression and the cell cycle is critical for appropriate cell growth and timely cell division. Failure of the mechanisms regulating these processes can result in proliferative diseases.
B. Greber, J. Perez-Bertoldi, K. Lim, A. Iavarone, D. Toso, E. Nogales   +5 more
semanticscholar   +1 more source

Replication factory activation can be decoupled from the replication timing program by modulating Cdk levels [PDF]

, 2010
In the metazoan replication timing program, clusters of replication origins located in different subchromosomal domains fire at different times during S phase. We have used Xenopus laevis egg extracts to drive an accelerated replication timing program in
Alexander M. Thomson, Berezney, Blasina, Blow, Blow, Boutros, Brown, Chong, Cohen, Dimitrova, Dimitrova, Dimitrova, Dimitrova, Donaldson, Eshaghi, Farkash-Amar, Feijoo, Ferenbach, Frouin, Ge, Gilbert, Goldberg, Goren, Hartley, Hayashi, Heichinger, Hiratani, Howe, J. Julian Blow, Jackson, Jeon, Karlsson-Rosenthal, Kitamura, Krasinska, Labit, Luciani, MacAlpine, Masumoto, Mickle, Moore, Nishitani, O'Keefe, Okuno, Peter J. Gillespie, Platani, Raghuraman, Raghuraman, Rempel, Santocanale, Sarkaria, Schübeler, Shechter, Shirahige, Strausfeld, Strausfeld, Swedlow, Tanaka, Vernon, White, Woodfine, Woodfine, Woodward, Wu, Zegerman, Zink   +64 more
core   +4 more sources

The Chemistry Development Kit (CDK) v2.0: atom typing, depiction, molecular formulas, and substructure searching

Journal of Cheminformatics, 2017
Background The Chemistry Development Kit (CDK) is a widely used open source cheminformatics toolkit, providing data structures to represent chemical concepts along with methods to manipulate such structures and perform computations on them.
Egon Willighagen, J. W. Mayfield, Jonathan Alvarsson, Arvid Berg, L. Carlsson, N. Jeliazkova, S. Kuhn, T. Pluskal, Miquel Rojas-Chertó, O. Spjuth, Gilleain M. Torrance, C. Evelo, R. Guha, C. Steinbeck   +13 more
semanticscholar   +1 more source

Evolution of systemic treatment for hormone-sensitive breast cancer: from sequential use of single agents to the upfront administration of drug combinations

Опухоли женской репродуктивной системы, 2016
Current standards of treatment of endocrine-dependent cancers (breast cancer (BC), prostate cancer) imply sequential use of endocrine therapy and cytotoxic agents: it is believed, that steroid hormone antagonists cease the division of transformed cells ...
E. N. Imyanitov
doaj   +1 more source

Inhibition of NF-κB-mediated signaling by the cyclin-dependent kinase inhibitor CR8 overcomes pro-survival stimuli to induce apoptosis in chronic lymphocytic leukemia cells [PDF]

, 2013
Purpose: Chronic lymphocytic leukemia (CLL) is currently incurable with standard chemotherapeutic agents, highlighting the need for novel therapies. Overcoming proliferative and cytoprotective signals generated within the microenvironment of lymphoid ...
Alison M. McCaig, Alison M. Michie, Byrd, Christian Berthou, Emilie Durieu, Emilio Cosimo, Helen Wheadon, Hervé Galons, Karine Le Ster, Kitada, Laurent Meijer, Luke J.M. Carter-Brzezinski, Michael T. Leach, Nassima Oumata, Pepper   +14 more
core   +1 more source

Proteogenomic characterization of cholangiocarcinoma

Hepatology, EarlyView., 2022
Proteogenomic characterization of cholangiocarcinoma with therapeutic strategies Abstract Background and Aims Cholangiocarcinoma (CCA) is a highly heterogeneous cancer with limited understanding and few effective therapeutic approaches. We aimed at providing a proteogenomic CCA characterization to inform biological processes and treatment ...
Mengjie Deng, Peng Ran, Lingli Chen, Yunzhi Wang, Zixiang Yu, Ke Cai, Jinwen Feng, Zhaoyu Qin, Yanan Yin, Subei Tan, Yang Liu, Chen Xu, Guoming Shi, Yuan Ji, Jian‐Yuan Zhao, Jian Zhou, Jia Fan, Yingyong Hou, Chen Ding   +18 more
wiley   +1 more source

Clinical approach for diagnosing chronic kidney disease based on a series of cases in dogs [PDF]

Arquivo Brasileiro de Medicina Veterinária e Zootecnia
Chronic kidney disease (CDK) is the condition most frequently diagnosed in nephrology in dogs. CDK is progressive and irreversible, but the patient can be treated to decrease the rate of progression and improve the quality of life.
A.M.F.R. Tovar, M.B. Carvalho, G.S. Silva, A. Bizare   +3 more
doaj   +1 more source

Biological Role of CDK 11 and 12 in Cell Cycle and its Function in Tumorigenesis

Pakistan Journal of Medicine and Dentistry, 2020
Uninhibited proliferation and abnormal cell cycle regulation are the hallmarks of cancer. The main role of cyclin dependent kinases is to regulate the cell cycle and cell proliferation. These protein kinases are frequently down regulated or up regulated
Danish Mohammad, Rida Tafveez, Zain JawedAbubaker, Shamim Mushtaq   +3 more
doaj   +1 more source