Results 41 to 50 of about 137,554 (368)
Cyclin-Dependent Kinase Inhibitors and Their Therapeutic Potential in Colorectal Cancer Treatment
Frontiers in Pharmacology, 2021 Cyclin-dependent kinases (CDKs) are key players in cell cycle regulation. So far, more than ten CDKs have been described. Their direct interaction with cyclins allow progression through G1 phase, transitions to S and G2 phase and finally through mitosis (
Oana-Maria Thoma +6 more
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Functional characterization of the diatom cyclin-dependent kinase A2 as a mitotic regulator reveals plant-like properties in a non-green lineage [PDF]
, 2015 Background: Cyclin-dependent kinases (CDKs) are crucial regulators of cell cycle progression in eukaryotes. The diatom CDKA2 was originally assigned to the classical A-type CDKs, but its cell cycle phase-specific transcription at the G2-to-M phase ...
Bowler, Chris +4 more
core +2 more sources
, 2022 Presentation at the CDK 20 years (#cdk20y) retreat in Bozen/Italy in April 2022, about the prehistoric, original and current state of the CDK.
openaire +2 more sources
Cdc2: a monopotent or pluripotent CDK? [PDF]
Cell Proliferation, 2011 Cell cycle progression is controlled by both extracellular and intracellular signalling molecules. It has been generally believed that cdc2/CDK1 only control G(2)-M transition in mammalian and many other higher eukaryotic cells. Accumulating evidence shows that cdc2 not only promotes G(2)-M transition but is also capable of regulating G(1) progress and
X. T. Hu, L. C. Moscinski
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The Journal of Cell Biology, 2007 ![Graphic][1] Cells still cycle in an embryo with only Cdk1. BARBACID/MACMILLAN We can't turn sugars into a good pinot noir, but we do resemble yeast in one surprising way. Like the fungi, mammals require only one cyclin-dependent kinase (cdk) to complete the cell cycle, say ...
openaire +2 more sources
Visualizing the metazoan proliferation-quiescence decision in vivo
eLife, 2020 Cell proliferation and quiescence are intimately coordinated during metazoan development. Here, we adapt a cyclin-dependent kinase (CDK) sensor to uncouple these key events of the cell cycle in Caenorhabditis elegans and zebrafish through live-cell ...
Rebecca C Adikes +20 more
doaj +1 more source
CDK 4/6 Inhibitors as Single Agent in Advanced Solid Tumors
Frontiers in Oncology, 2018 Cyclin-dependent kinases (CDK) 4/6 inhibitors, namely abemaciclib, palbociclib, and ribociclib, interfere with cell cycle progression, induce cell senescence and might promote cancer cell disruption by a cytotoxic T cells-mediated effect.
F. Schettini +10 more
semanticscholar +1 more source
Cdks and the Drosophila cell cycle [PDF]
Current Opinion in Genetics & Development, 1997 Cyclin-dependent kinases play essential roles in driving the cell cycle. Much progress has been made in Drosophila over the past year in identifying the specific requirements for individual cyclins in particular cell cycle events. These studies encompass many aspects of the cell cycle, from the addition of a G1 phase to the cell cycle during ...
Peter Follette, Patrick H. O'Farrell
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Whi5 regulation by site specific CDK-phosphorylation in Saccharomyces cerevisiae.
PLoS ONE, 2009 The Whi5 transcriptional repressor is a negative regulator of G1 cell cycle progression in Saccharomyces cerevisiae and is functionally equivalent to the Retinoblastoma (Rb) tumor suppressor protein in mammals. In early G1, Whi5 binds to and inhibits SBF
Michelle V Wagner +5 more
doaj +1 more source
CDK-1 Inhibition in G2 Stabilizes Kinetochore-Microtubules in the following Mitosis. [PDF]
PLoS ONE, 2016 Cell proliferation is driven by cyclical activation of cyclin-dependent kinases (CDKs), which produce distinct biochemical cell cycle phases. Mitosis (M phase) is orchestrated by CDK-1, complexed with mitotic cyclins.
A Sophia Gayek, Ryoma Ohi
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