Results 51 to 60 of about 138,770 (367)
Spectrum and Degree of CDK Drug Interactions Predicts Clinical Performance
Molecular Cancer Therapeutics, 2016 Therapeutically targeting aberrant intracellular kinase signaling is attractive from a biological perspective but drug development is often hindered by toxicities and inadequate efficacy.
Ping Chen +13 more
semanticscholar +1 more source
Targeting the cyclin-dependent kinases (CDK) 4/6 in estrogen receptor-positive breast cancers
Breast Cancer Research, 2016 Despite significant advances in early detection and treatment, breast cancer still remains a major cause of morbidity and mortality for women. Our understanding of the molecular heterogeneity of the disease has significantly expanded over the past decade
R. Finn, A. Aleshin, D. Slamon
semanticscholar +1 more source
A New Trick for Cyclin-Cdk [PDF]
Developmental Cell, 2003 New work in Drosophila demonstrates that cdk4 loss causes phenotypes similar to the loss of JAK/STAT pathway components. Cdk4 overexpression can bypass requirements for JAK but not STAT. These results demonstrate a new function for Cdk4 and a new mode of STAT activation.
Debra L. Silver, Denise J. Montell
openaire +3 more sources
Coordination of chromatid separation and spindle elongation by antagonistic activities of mitotic and S-phase CDKs. [PDF]
PLoS Genetics, 2013 Because cohesion prevents sister-chromatid separation and spindle elongation, cohesion dissolution may trigger these two events simultaneously. However, the relatively normal spindle elongation kinetics in yeast cohesin mutants indicates an additional ...
Fengshan Liang +2 more
doaj +1 more source
A quantitative model of the initiation of DNA replication in Saccharomyces cerevisiae predicts the effects of system perturbations. [PDF]
, 2012 BackgroundEukaryotic cell proliferation involves DNA replication, a tightly regulated process mediated by a multitude of protein factors. In budding yeast, the initiation of replication is facilitated by the heterohexameric origin recognition complex ...
DaSilva, Lance F +6 more
core +3 more sources
Applications of the InChI in cheminformatics with the CDK and Bioclipse [PDF]
Journal of Cheminformatics, 2013 The InChI algorithms are written in C++ and not available as Java library. Integration into software written in Java therefore requires a bridge between C and Java libraries, provided by the Java Native Interface (JNI) technology.We here describe how the InChI library is used in the Bioclipse workbench and the Chemistry Development Kit (CDK ...
Spjuth, Ola +3 more
openaire +5 more sources
Indian Journal of Medical and Paediatric Oncology, 2019 The cyclin D-cyclin-dependent kinase (CDK) 4/6 pathway controls the cell cycle machinery by regulating the G1-to-S-phase transition. Dysregulation of this pathway, resulting in increased cellular proliferation, is frequently observed in a variety of ...
Tamojit Chaudhuri +8 more
doaj +1 more source
Genetic background and climatic droplet keratopathy incidence in a Mapuche population from Argentina. [PDF]
PLoS ONE, 2013 PURPOSE:To determine whether the incidence of and susceptibility to climatic droplet keratopathy (CDK), an acquired, often bilateral degenerative corneal disease, is influenced by the genetic background of the individuals who exhibit the disorder ...
Theodore G Schurr +5 more
doaj +1 more source
Genes & Development, 1994 Cell-cell contact and TGF-beta can arrest the cell cycle in G1. Mv1Lu mink epithelial cells arrested by either mechanism are incapable of assembling active complexes containing the G1 cyclin, cyclin E, and its catalytic subunit, Cdk2.
K. Polyak +6 more
semanticscholar +1 more source
Dynactin-dependent cortical dynein and spherical spindle shape correlate temporally with meiotic spindle rotation in Caenorhabditis elegans. [PDF]
, 2015 Oocyte meiotic spindles orient with one pole juxtaposed to the cortex to facilitate extrusion of chromosomes into polar bodies. In Caenorhabditis elegans, these acentriolar spindles initially orient parallel to the cortex and then rotate to the ...
Andaya, Armann +9 more
core +1 more source