Results 141 to 150 of about 67,859 (329)

ATM, ATR and DNA-PKcs expressions correlate to adverse clinical outcomes in epithelial ovarian cancers [PDF]

, 2014
Background: Ataxia-telangiectasia mutated (ATM), ataxia-telangiectasia mutated and rad3 related (ATR) and DNA-dependent protein kinase catalytic sub-unit (DNA-PKcs) play critical roles in DNA damage response (DDR) by linking DNA damage sensing to DDR ...
Abdel-Fatah, Banerjee, Bensimon, Bhatti, Branzei, Brem, Chen, Chou, Colton, Crijns, Crijns, Dejmek, Ditch, Flynn, Hsu, Hurov, Kong, Kononen, Levy, Lewis, Marchetti, McShane, Nam, Neal, Rabik, Ratner, Romero, Sangster-Guity, Shen, Shiloh, Shiloh, Sorensen, Sultana, Sultana, Weterings, Yoshida   +35 more
core   +2 more sources

Phosphorylation at the Helm: Kinase‐Mediated Regulation of Primary Cilia Assembly and Disassembly

Cytoskeleton, EarlyView.
ABSTRACT The primary cilium serves as an antenna of most vertebrate cells and is important for conveying cues from several signaling pathways into appropriate cellular responses during development and homeostasis. Cilia assembly and disassembly processes are thought to be strictly controlled; however, the precise nature of molecular events underlying ...
Andrea Lacigová, Lukáš Čajánek
wiley   +1 more source

The aberrant upstream pathway regulations of CDK1 protein were implicated in the proliferation and apoptosis of ovarian cancer cells

Journal of Ovarian Research, 2017
Background Upregulation of Cyclin dependent kinase 1 (CDK1) protein is closely related with the prognosis of several malignant tumors. Chk1-CDC25C-CDK1 signaling and P53-P21WAF1-CDK1 signaling pathways are closely related with the cell cycle G2/M phase ...
Ruitao Zhang, Huirong Shi, Fang Ren, Minghui Zhang, Pengcheng Ji, Wenwen Wang, Chuanna Liu   +6 more
doaj   +1 more source

The laminA/NF-Y protein complex reveals an unknown transcriptional mechanism on cell proliferation [PDF]

, 2016
Lamin A is a component of the nuclear matrix that also controls proliferation by largely unknown mechanisms. NF-Y is a ubiquitous protein involved in cell proliferation composed of three subunits (-YA -YB -YC) all required for the DNA ...
Alonzi, Tonino, Capogrossi, Maurizio C., Carlomosti, Fabrizio, Ciana, Paolo, Cicchillitti, Lucia, Dell'Anna, Maria Lucia, Dell'Omo, Giulia, Gurtner, Aymone, Magenta, Alessandra, Mancone, Carmine, Manni, Isabella, Piaggio, Giulia, Picardo, Mauro, Regazzo, Giulia, Rizzo, Maria Giulia, Spagnuolo, Manuela, Tripodi, Marco   +16 more
core   +2 more sources

Chromosome alignment and Kif18A action rely on spindle-localized control of Cdk1 activity

Frontiers in Cell and Developmental Biology
IntroductionDuring mitosis, chromosome alignment at the mitotic spindle equator grants correct chromosome segregation and proper nuclei formation in daughter cells.
Angela Flavia Serpico, Caterina Pisauro, Asia Trano, Domenico Grieco, Domenico Grieco   +4 more
doaj   +1 more source

Identification of transcriptional and metabolic programs related to mammalian cell size [PDF]

, 2014
SummaryBackgroundRegulation of cell size requires coordination of growth and proliferation. Conditional loss of cyclin-dependent kinase 1 in mice permits hepatocyte growth without cell division, allowing us to study cell size in vivo using ...
Bjorklund, Mikael, Caldez, Matias J., Diril, M. Kasim, Fuhrer, Tobias, Kaldis, Philipp, Miettinen, Teemu P., Pessa, Heli K. J., Sauer, Uwe   +7 more
core   +3 more sources

Organoid‐tissue extracellular vesicles

Interdisciplinary Medicine, EarlyView.
Abstract Extracellular vesicles (EVs) are lipid bilayer structures secreted by cells that act as intercellular messengers. Tissue‐derived EVs (TEVs), harvested from the tissue interstitium, directly reflect the actual physiological or pathological state of the tissue microenvironment.
Han Liu, Ting Cheng, Guangfeng Li, Zhidao Xia, Chenglong Wang, Ke Xu, Jiacan Su   +6 more
wiley   +1 more source

Fcp1 phosphatase controls Greatwall kinase to promote PP2A-B55 activation and mitotic progression

eLife, 2015
During cell division, progression through mitosis is driven by a protein phosphorylation wave. This wave namely depends on an activation-inactivation cycle of cyclin B-dependent kinase (Cdk) 1 while activities of major protein phosphatases, like PP1 and ...
Rosa Della Monica, Roberta Visconti, Nando Cervone, Angela Flavia Serpico, Domenico Grieco   +4 more
doaj   +1 more source

Resetting a functional G1 nucleus after mitosis [PDF]

, 2016
© The Author(s) 2015. The maintenance of the correct cellular information goes beyond the simple transmission of an intact genetic code from one generation to the next. Epigenetic changes, topological cues and correct protein-protein interactions need to
De Castro, IJ, Gokhan, E, Vagnarelli, P
core   +2 more sources

Calpain Proteases and the Evolving Signaling Network in Insect Embryonic Patterning

Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, EarlyView.
Insect embryonic Dorsal‐Ventral (DV) patterning relies on the BMP and Toll pathways to different extents. Calcium‐dependent cystein proteases of the Calpain family also exert an important function to pattern the DV axis. In Drosophila, Calpain A cleaves the Cactus/IkappaB inhibitor and modifies Toll signals in ventral regions of the embryo. In Rhodnius
Alison Julio, Helena Araujo
wiley   +1 more source