Results 31 to 40 of about 14,231 (159)
Computational and Structural Biotechnology Journal, 2019 Deregulation of Cdk5 is a hallmark in neurodegenerative diseases and its complex with p25 forms Cdk5/p25, thereby causes severe neuropathological insults.
Amir Zeb +5 more
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Cell Adhesion & Migration, 2010 Cell adhesion is a fundamental property of epithelial cells required for anchoring, migration and survival. During cell migration, the formation and disruption of adhesion sites is stringently regulated by integration of multiple, sequential signals acting in distinct regions of the cell.
Brajendra K, Tripathi, Peggy S, Zelenka
openaire +2 more sources
PLoS ONE, 2015 Cyclin-dependent kinase 5 (CDK5) is a cytoplasmic serine/ threonine kinase. Knockdown of CDK5 enhances paclitaxel sensitivity in human ovarian cancer cells.
Shu Zhang +16 more
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Ocular expression of cyclin‐dependent kinase 5 in patients with proliferative diabetic retinopathy
Journal of Diabetes Investigation, 2022 Aims/Introduction Inhibition of peroxisome proliferator‐activated receptor gamma (PPARγ) phosphorylation mediated by cyclin‐dependent kinase 5 (Cdk5) is one of the main mechanisms of action of antidiabetic drugs.
Hiroki Sano +6 more
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Focusing on cyclin-dependent kinases 5: A potential target for neurological disorders
Frontiers in Molecular Neuroscience, 2022 Cyclin-dependent kinases 5 (Cdk5) is a special member of proline-directed serine threonine kinase family. Unlike other Cdks, Cdk5 is not directly involved in cell cycle regulation but plays important roles in nervous system functions. Under physiological
Zhen Tian +3 more
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Cyclin-dependent kinase 5 acts as a promising biomarker in clear cell Renal Cell Carcinoma
BMC Cancer, 2019 Background This research provides the first evidence of CDK5 in ccRCC prognosis and correlation with different p21 expression in overall survival (OS) analysis.
Liangsong Zhu +4 more
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Inhibition of Cdk5 increases osteoblast differentiation and bone mass and improves fracture healing
Bone Research, 2022 Identification of regulators of osteoblastogenesis that can be pharmacologically targeted is a major goal in combating osteoporosis, a common disease of the elderly population. Here, unbiased kinome RNAi screening in primary murine osteoblasts identified
Mubashir Ahmad +17 more
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Cdk5 in Neuroskeletal Dynamics [PDF]
Neurosignals, 2003 Signal transduction in a broad sense refers to intracellular, molecular changes triggered by cues outside the cell in order to bring about behavioral responses such as migration, differentiation, secretion, or death. Until recently, the best-studied end targets of signal transduction pathways were transcriptional regulators that contribute to changes ...
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Regulation of Kalirin by Cdk5 [PDF]
Journal of Cell Science, 2008 Kalirin, one of the few Rho guanine nucleotide exchange factors (GEFs) that contains spectrin-like repeats, plays a critical role in axon extension and maintenance of dendritic spines. PC12 cells were used to determine whether Cdk5, a critical participant in both processes, regulates the action of Kalirin.
Xiaonan, Xin +6 more
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Biological functions of CDK5 and potential CDK5 targeted clinical treatments
Oncotarget, 2017 Cyclin dependent kinases are proline-directed serine/threonine protein kinases that are traditionally activated upon association with a regulatory subunit. For most CDKs, activation by a cyclin occurs through association and phosphorylation of the CDK's T-loop.
Shupp, Alison +2 more
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