Results 31 to 40 of about 28,778 (201)
Cdk5 controls lymphatic vessel development and function by phosphorylation of Foxc2. [PDF]
, 2015 The lymphatic system maintains tissue fluid balance, and dysfunction of lymphatic vessels and valves causes human lymphedema syndromes. Yet, our knowledge of the molecular mechanisms underlying lymphatic vessel development is still limited. Here, we show
Adams, R.H. +12 more
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A Cdk5-derived peptide inhibits Cdk5/p25 activity and improves neurodegenerative phenotypes
Proceedings of the National Academy of Sciences, 2023 Aberrant activity of cyclin-dependent kinase (Cdk5) has been implicated in various neurodegenerative diseases. This deleterious effect is mediated by pathological cleavage of the Cdk5 activator p35 into the truncated product p25, leading to prolonged Cdk5 activation and altered substrate specificity. Elevated p25 levels have been reported in humans and
Ping-Chieh Pao +17 more
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Cancer Cell International, 2019 Background Bridging integrator 1 (BIN1) has showed outstanding tumor-suppressive potential via inhibiting c-MYC-mediated tumorigenesis. However, a frequent phosphorylation of c-MYC at Ser-62 site could block the BIN1/c-MYC interaction and limits the ...
Xiangyu Zhang +8 more
doaj +1 more source
The Structural Perspective on CDK5 [PDF]
Neurosignals, 2003 Cyclin-dependent kinase 5 (CDK5) plays an essential role in the development of the central nervous system during mammalian embryogenesis. In the adult, CDK5 is required for the maintenance of neuronal architecture. Its deregulation has profound cytotoxic effects and has been implicated in the development of neurodegenerative diseases such as Alzheimer ...
Mapelli, Marina, Musacchio, Andrea
openaire +4 more sources
Active Cdk5 Immunoprecipitation and Kinase Assay
Bio-Protocol, 2017 Cdk5 activity is regulated by the amounts of two activator proteins, p35 and p39 (Tsai et al., 1994; Zheng et al., 1998; Humbert et al., 2000). The p35-Cdk5 and p39-Cdk5 complexes have differing sensitivity to salt and detergent concentrations (Hisanaga ...
Andrew Bankston, Li Ku, Yue Feng
doaj +1 more source
Dopaminergic and glutamatergic signaling crosstalk in Huntington's disease neurodegeneration : the role of p25/cyclin-dependent kinase 5 [PDF]
, 2008 Altered glutamatergic and dopaminergic signaling has been proposed as contributing to the specific striatal cell death observed in Huntington's disease (HD).
Alberch i Vié, Jordi +5 more
core +2 more sources
Identification of LIMK2 as a therapeutic target in castration resistant prostate cancer [PDF]
, 2019 This study identified LIMK2 kinase as a disease-specific target in castration resistant prostate cancer (CRPC) pathogenesis, which is upregulated in response to androgen deprivation therapy, the current standard of treatment for prostate cancer. Surgical
Broman, Meaghan M. +13 more
core +1 more source
Regulation of hippocampal and behavioral excitability by cyclin-dependent kinase 5.
PLoS ONE, 2009 Cyclin-dependent kinase 5 (Cdk5) is a proline-directed serine/threonine kinase that has been implicated in learning, synaptic plasticity, neurotransmission, and numerous neurological disorders.
Ammar H Hawasli +7 more
doaj +1 more source
Computational and Structural Biotechnology Journal, 2019 Deregulation of Cdk5 is a hallmark in neurodegenerative diseases and its complex with p25 forms Cdk5/p25, thereby causes severe neuropathological insults.
Amir Zeb +5 more
doaj +1 more source
Focusing on cyclin-dependent kinases 5: A potential target for neurological disorders
Frontiers in Molecular Neuroscience, 2022 Cyclin-dependent kinases 5 (Cdk5) is a special member of proline-directed serine threonine kinase family. Unlike other Cdks, Cdk5 is not directly involved in cell cycle regulation but plays important roles in nervous system functions. Under physiological
Zhen Tian +3 more
doaj +1 more source