Results 41 to 50 of about 28,778 (201)
CDK5 activator p35 downregulates E‐cadherin precursor independently of CDK5
FEBS Letters, 2008 Dysfunction of E-cadherins often results in metastasis of cancerous cells. Here we show that p35, a critical regulator of cyclin-dependent kinase 5 (CDK5), specifically depletes the precursor form of E-cadherin, but not the mature form, by using a precursor-specific antibody.
Lin, Shuyong +4 more
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Inactivation of Cyclin-Dependent Kinase 5 in Hair Cells Causes Hearing Loss in Mice
Frontiers in Molecular Neuroscience, 2018 Cyclin-dependent kinase 5 (CDK5) is abundantly expressed in post-mitotic cells including neurons. It is involved in multiple cellular events, such as cytoskeletal dynamics, signaling cascades, gene expression, and cell survival, et al.
Xiaoyan Zhai +7 more
doaj +1 more source
Cell Adhesion & Migration, 2010 Cell adhesion is a fundamental property of epithelial cells required for anchoring, migration and survival. During cell migration, the formation and disruption of adhesion sites is stringently regulated by integration of multiple, sequential signals acting in distinct regions of the cell.
Brajendra K, Tripathi, Peggy S, Zelenka
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PLoS ONE, 2015 Cyclin-dependent kinase 5 (CDK5) is a cytoplasmic serine/ threonine kinase. Knockdown of CDK5 enhances paclitaxel sensitivity in human ovarian cancer cells.
Shu Zhang +16 more
doaj +1 more source
Ocular expression of cyclin‐dependent kinase 5 in patients with proliferative diabetic retinopathy
Journal of Diabetes Investigation, 2022 Aims/Introduction Inhibition of peroxisome proliferator‐activated receptor gamma (PPARγ) phosphorylation mediated by cyclin‐dependent kinase 5 (Cdk5) is one of the main mechanisms of action of antidiabetic drugs.
Hiroki Sano +6 more
doaj +1 more source
Cyclin-dependent kinase 5 acts as a promising biomarker in clear cell Renal Cell Carcinoma
BMC Cancer, 2019 Background This research provides the first evidence of CDK5 in ccRCC prognosis and correlation with different p21 expression in overall survival (OS) analysis.
Liangsong Zhu +4 more
doaj +1 more source
Inhibition of Cdk5 increases osteoblast differentiation and bone mass and improves fracture healing
Bone Research, 2022 Identification of regulators of osteoblastogenesis that can be pharmacologically targeted is a major goal in combating osteoporosis, a common disease of the elderly population. Here, unbiased kinome RNAi screening in primary murine osteoblasts identified
Mubashir Ahmad +17 more
doaj +1 more source
Advances in tetrahydropyrido[1,2-a]isoindolone (valmerins) series: Potent glycogen synthase kinase 3 and cyclin dependent kinase 5 inhibitors. [PDF]
, 2015 International audienceAn efficient synthetic strategy was developed to modulate the structure of the tetrahydropyridine isoindolone (Valmerin) skeleton. A library of more than 30 novel final structures was generated.
Akssira, Mohamed +12 more
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Cdk5 in Neuroskeletal Dynamics [PDF]
Neurosignals, 2003 Signal transduction in a broad sense refers to intracellular, molecular changes triggered by cues outside the cell in order to bring about behavioral responses such as migration, differentiation, secretion, or death. Until recently, the best-studied end targets of signal transduction pathways were transcriptional regulators that contribute to changes ...
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Regulation of Kalirin by Cdk5 [PDF]
Journal of Cell Science, 2008 Kalirin, one of the few Rho guanine nucleotide exchange factors (GEFs) that contains spectrin-like repeats, plays a critical role in axon extension and maintenance of dendritic spines. PC12 cells were used to determine whether Cdk5, a critical participant in both processes, regulates the action of Kalirin.
Xiaonan, Xin +6 more
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