Results 51 to 60 of about 28,778 (201)

Mechanisms Regulating the Association of Protein Phosphatase 1 with Spinophilin and Neurabin [PDF]

, 2018
Protein phosphorylation is a key mediator of signal transduction, allowing for dynamic regulation of substrate activity. Whereas protein kinases obtain substrate specificity by targeting specific amino acid sequences, serine/threonine phosphatase ...
Baucum, Anthony J., II, Edler, Michael C., Kaur, Harjot, Morris, Cameron W., Salek, Asma B., Watkins, Darryl S., Yamamoto, Bryan K.   +6 more
core   +1 more source

Forebrain-specific deletion of Cdk5 in pyramidal neurons results in mania-like behavior and cognitive impairment [PDF]

, 2017
Cyclin-dependent kinase 5 (Cdk5) is associated with synaptic plasticity and cognitive function. Previous reports have demonstrated that Cdk5 is necessary for memory formation, although others have reported Cdk5 conditional knockout mouse models ...
Cho, Sukhee, Rudenko, Andrii, Su, Susan Chih-Chieh, Tsai, Li-Huei   +3 more
core   +1 more source

Gene expression profiles of skin from cyclin dependent kinases 5-knockdown mice [PDF]

Animal Bioscience
Objective This study aimed to identify genes regulated by cyclin dependent kinases 5 (CDK5) that participate in hair pigmentation in mice. Methods The mRNA expression profiles of skin samples from CDK5-knockdown mice were constructed using high ...
Shanshan Yang, Dingxing Jiao, Tao Song, Ping Rui, Ruiwen Fan, Zengjun Ma   +5 more
doaj   +1 more source

Intranasal rapamycin ameliorates Alzheimer-like cognitive decline in a mouse model of Down syndrome [PDF]

, 2018
Background: Down syndrome (DS) individuals, by the age of 40s, are at increased risk to develop Alzheimer-like dementia, with deposition in brain of senile plaques and neurofibrillary tangles.
Arena, Andrea, Barone, Eugenio, Blarzino, Carla, Butterfield, D. Allan, Di Domenico, Fabio, Lanzillotta, Chiara, Mosca, Luciana, Perluigi, Marzia, Tramutola, Antonella, Zuliani, Ilaria   +9 more
core   +3 more sources

CDK5: Key Regulator of Apoptosis and Cell Survival

Biomedicines, 2019
The atypical cyclin-dependent kinase 5 (CDK5) is considered as a neuron-specific kinase that plays important roles in many cellular functions including cell motility and survival. The activation of CDK5 is dependent on interaction with its activator p35,
Rabih Roufayel, Nimer Murshid
doaj   +1 more source

Inhibiting cyclin-dependent kinase 5 in the nucleus accumbens enhances the expression of amphetamine-induced locomotor conditioning [PDF]

, 2014
When psychostimulant drugs like amphetamine are administered repeatedly in the presence of a contextual stimulus complex, long-lasting associations form between the unconditioned effects of the drug and the contextual stimuli.
B.F. Singer, Banasikowski, Benavides, Bibb, Britt, Buraei, Cervo, Cruz, Fischer, Fischer, Gipson, Hawasli, J. Forneris, Leyton, Leyton, Li, Moses, P. Vezina, Pierce, Price, Robinson, Singer, Stewart, Taylor, Vezina, Vezina, Vezina, Xin   +27 more
core   +1 more source

DualPG‐DTA: A Large Language Model‐Powered Graph Neural Network Framework for Enhanced Drug‐Target Affinity Prediction and Discovery of Novel CDK9 Inhibitors Exhibiting in Vivo Anti‐Leukemia Activity

Advanced Science, EarlyView.
This study introduces DualPG‐DTA, a framework integrating two pre‐trained models to generate molecular and protein representations. It constructs dual graphs processed by specialized neural networks with dynamic attention for feature fusion, achieving superior benchmark performance.
Yihao Chen, Jindi Huang, Cong Liu, Shipeng Zhang, Xinze Li, Zhang Zhang, Tie‐Gen Chen, Ling Wang   +7 more
wiley   +1 more source

Dual Targeting of Tau Kinases and Autophagy by Abemaciclib Independent of CDK4/6 Inhibition

Advanced Science, EarlyView.
Abemaciclib rescues cognitive function and attenuates tau pathology in Alzheimer's disease models, but not through its known cancer‐fighting mechanism. This study demonstrates that abemaciclib operates independently of CDK4/6 inhibition, instead directly targeting tau kinases CaMKII and GSK3β while simultaneously promoting autophagic clearance of ...
Jihui Han, June‐Hyun Jeong, Dongjoon Lee, Yujin Jung, Yujin Jin, Eun Sun Jung, Haeng Jun Kim, Woo Youn Kim, Chang‐Han Lee, Inhee Mook‐Jung   +9 more
wiley   +1 more source

CDK5 [PDF]

Cell Adhesion & Migration, 2009
Neurogenesis takes place in the mammalian hippocampus throughout the whole life and deficient adult hippocampal neurogenesis has been related to neurological conditions like Alzheimer disease (AD), Parkinson disease (PD) and epilepsy. The molecular mechanisms by which immature neurons and their extending neurites find their appropriate position and ...
Albert, Tobias, Monika, Saxena, Vincent, Lelievre   +2 more
openaire   +2 more sources

TFP5/TP5 peptide provides neuroprotection in the MPTP model of Parkinson′s disease

Neural Regeneration Research, 2016
Cyclin-dependent kinase 5 (Cdk5) is a member of the serine-threonine kinase family of cyclin-dependent kinases. Cdk5 is critical to normal mammalian nervous system development and plays important regulatory roles in multiple cellular functions.
B K Binukumar, Harish C Pant
doaj   +1 more source