Results 71 to 80 of about 14,231 (159)

CRISPR Enabled Precision Oncology: From Gene Editing to Tumor Microenvironment Remodeling

Med Research, Volume 2, Issue 1, Page 106-129, March 2026.
CRISPR technology has progressed from a prokaryotic immune system to a diverse suite of editing platforms, including Cas nucleases, base and prime editors, and RNA‐targeting enzymes. These advances enable precise genomic and epigenomic interventions, high‐throughput functional screening, and immune engineering.
Kailai Li, Peixin Huang, Yue Qian, Anqi Lin, Jingjun He, Junyi Shen, Li Chen, Kai Miao, Jian Zhang   +8 more
wiley   +1 more source

Proteomic insights into the invasiveness and tumor progression of non‐functioning pituitary adenomas: A scoping review

Journal of Neuroendocrinology, Volume 38, Issue 3, March 2026.
Abstract Nonfunctioning pituitary adenomas (NFPAs) are common intracranial tumors that, despite being histologically benign, can exhibit invasive growth, as well as postoperative tumor progression. Surgical resection is the primary treatment of choice; however, residual tumor tissue is frequently observed, with between 30% and 50% of these cases ...
Thomas Skoglund, Linus Köster, Annika Thorsell, Oskar Ragnarsson, Gudmundur Johannsson, Tobias Hallén   +5 more
wiley   +1 more source

Mechanistic insight of cyclin-dependent kinase 5 in modulating lung cancer growth

Chinese Journal of Physiology, 2019
Lung harbors the growth of primary and secondary tumors. Even though numerous factors regulate the complex signal transduction and cytoskeletal remodeling toward the progression of lung cancer, cyclin-dependent kinase 5 (Cdk5), a previously known kinase ...
G. M. Shazzad Hossain Prince, Tsung-Ying Yang, Ho Lin, Mei-Chih Chen   +3 more
doaj   +1 more source

Role of Septin7 in mitochondrial dynamics and oxidative metabolism in C2C12 skeletal muscle cells

The Journal of Physiology, Volume 604, Issue 5, Page 1971-1994, 1 March 2026.
Abstract figure legend Knockdown of Septin7 alters the expression of markers responsible for mitochondrial dynamics. Members of the electron transport chain are also affected by diminished Septin7 level resulting in functional changes of mitochondrial respiration. Abstract Mitochondria are dynamic organelles that undergo fusion and fission.
Andrea Telek, Ivett Gabriella Szabó, Anikó Keller‐Pintér, Mónika Gönczi, Eliza Guti, László Szabó, Brigitta Tillmann, Zoltán Márton Kohler, László Juhász, Péter Bai, Szilárd Póliska, Zsuzsanna Gaál, László Csernoch, János Fodor   +13 more
wiley   +1 more source

DualPG‐DTA: A Large Language Model‐Powered Graph Neural Network Framework for Enhanced Drug‐Target Affinity Prediction and Discovery of Novel CDK9 Inhibitors Exhibiting In Vivo Anti‐Leukemia Activity

Advanced Science, Volume 13, Issue 12, 27 February 2026.
This study introduces DualPG‐DTA, a framework integrating two pre‐trained models to generate molecular and protein representations. It constructs dual graphs processed by specialized neural networks with dynamic attention for feature fusion, achieving superior benchmark performance.
Yihao Chen, Jindi Huang, Cong Liu, Shipeng Zhang, Xinze Li, Zhang Zhang, Tie‐Gen Chen, Ling Wang   +7 more
wiley   +1 more source

All-Trans Retinoic Acid Induces DU145 Cell Cycle Arrest through Cdk5 Activation

Cellular Physiology and Biochemistry, 2014
Background/Aims: All-trans retinoic acid (ATRA), the active form of vitamin A, plays an important role in the growth arrest of numerous types of cancer cells.
Eugene Lin, Mei-Chih Chen, Chih-Yang Huang, Shih-Lan Hsu, William J. Huang, Mao-Sheng Lin, Jungle Chi-Hsiang Wu, Ho Lin   +7 more
doaj   +1 more source

Computational Algorithmic Innovations in Differential Equation‐Based Dynamic Process Modeling

Engineering Reports, Volume 8, Issue 2, February 2026.
This study presents algorithmic innovations in Neural Ordinary Differential Equations (NeuralODEs) for dynamic process modeling of complex biochemical systems. Using the DARPP‐32 signaling network as a benchmark, the proposed framework demonstrates accurate replication of ODE and Rule‐Based Model behaviors while offering enhanced modularity ...
Guobin Zeng
wiley   +1 more source

Cell-Penetrating Fragments of the Cdk5 Regulatory Subunit Are Protective in Models of Neurodegeneration

Pharmaceuticals, 2010
Cdk5 is essential for neuronal differentiation processes in the brain. Activation of Cdk5 requires the association with the mostly neuron-specific p35 or p39.
Jan Liman, Jochen H. Weishaupt, Mathias Bähr, Gunnar P.H. Dietz   +3 more
doaj   +1 more source

Stress-Induced CDK5 Activation Disrupts Axonal Transport via Lis1/Ndel1/Dynein

Cell Reports, 2015
Axonal transport is essential for neuronal function, and defects in transport are associated with multiple neurodegenerative diseases. Aberrant cyclin-dependent kinase 5 (CDK5) activity, driven by the stress-induced activator p25, also is observed in ...
Eva Klinman, Erika L.F. Holzbaur
doaj   +1 more source

Cdk5 protects huntingtin

The Journal of Cell Biology, 2005
![Graphic][1] Cdk5 (red) phosphorylates htt (green) and protects it from caspases.A cyclin-dependent kinase protects neurons from toxic fragments of huntingtin (htt), according to Luo et al.
openaire   +2 more sources