Results 151 to 160 of about 61,476 (246)

Insights Into the Interplay Between the Senescent Cells and Immune Cells. [PDF]

Aging Cell
Jaros M, Schmidt M, Neubert L, Kamp JC, von Vietinghoff S, Bräsen JH, Schmitt R, Melk A.   +7 more
europepmc   +1 more source

Macrophage Lipid Homeostasis Drives IVDD via a Senescence‐Dependent Impairment of Efferocytosis

Cell Proliferation, EarlyView.
Intervertebral disc degeneration (IVDD) has been a leading cause of low back pain and lacks disease‐modifying therapies. Although dysregulated disc lipid metabolism is implicated, its impact on the immune microenvironment, particularly macrophages, remains unknown.
Jinyu Wang, Shiyong Ling, Qi Wang, Xuege Qiao, Jianpeng Xing, Siyang Ji, Linhui Han, Chen Yan, Zhishen Niu, Lei Yuan, Baolian Zhao, Kaiqiang Sun, Jiangang Shi   +12 more
wiley   +1 more source

Cytology‐First Diagnostic Workflow for Melanoma of Unknown Primary With Molecular Profiling

Cytopathology, EarlyView.
Cytology‑first diagnostic workflow for melanoma of unknown primary. Fine‑needle aspiration of an enlarged lymph node enables rapid cytologic evaluation and immunocytochemical confirmation of melanocytic lineage (SOX10). This early cytologic diagnosis facilitates timely surgical excision and comprehensive genomic profiling, supporting integrated ...
Hong Yu, Mokhtar Abdelhammed, Xu Cao, Nisha S. Ramani   +3 more
wiley   +1 more source

Sex differences and psycho‐oncological support needs in patients with high melanoma risk and melanoma survivors

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Summary Background and objectives Despite rising survival rates, emotional distress remains a major issue for melanoma patients. However, survivors and individuals at increased risk of melanoma are rarely included in distress assessments, leaving their specific needs poorly understood.
Alina M. Torrez, Alexander P. E. Michels, Diana Zwahlen, Elisabeth V. Goessinger, Sara E. Cerminara, Armelle Odermatt, Vanessa Zahner, Jill Simon, Julia‐Tatjana Maul, Alexander A. Navarini, Lara Valeska Maul   +10 more
wiley   +1 more source

Integrative network analysis identifies candidate genes shared between ferroptosis and cuproptosis pathways in rheumatoid arthritis pathogenesis. [PDF]

PLoS One
Ahmad A, Khalil S, Law D, De Los Ríos-Escalante PR, Abdel-Maksoud MA, Almutairi S, Alabbad AF, Ahmad W, Ahmad A.   +8 more
europepmc   +1 more source

Update of the S1‐guideline atypical fibroxanthoma (AFX) and pleomorphic dermal sarcoma (PDS)

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Summary Atypical fibroxanthoma (AFX) and pleomorphic dermal sarcoma (PDS) are rare cutaneous neoplasms representing histomorphological, genetic as well as epigenetic variants of one disease spectrum. Both tumors manifest as nonspecific, often ulcerated nodules in chronically sun‐damaged skin. AFX is a well‐demarcated, often rapidly growing tumor.
Doris Helbig, Mirjana Ziemer, Diana Crisan, Edgar Dippel, Michael Erdmann, Uwe Hillen, Muemtaz Koeksal, Ulrike Leiter, Thomas Mentzel, Lars Erik Podleska, Jochen Utikal, Dagmar von Bubnoff, Carsten Weishaupt, Selma Ugurel   +13 more
wiley   +1 more source

Genetics‐Informed Pharmacological Intervention in Gestational Diabetes Mellitus: Current Therapeutic Alignment, Emerging Targets and a Translational Roadmap

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Background Gestational diabetes mellitus (GDM) complicates roughly one in seven pregnancies and predicts later maternal type 2 diabetes mellitus (T2DM). Yet its pharmacological management still rests on a handful of agents (insulin, metformin and glibenclamide), none of them selected on the basis of the disease's molecular genetics.
Wael Osman
wiley   +1 more source

The critical issue of grade 2 vs grade 3 in IDH-mutant gliomas. [PDF]

Neuro Oncol
Ng HK.
europepmc   +1 more source

Mechanisms underpinning the progression of nondysplastic Barrett's oesophagus to cancer

The FEBS Journal, EarlyView.
Barrett's oesophagus confers a low but significant cancer risk. The condition is common but we do not have effective biomarkers to identify susceptible patients. We believe that there is no single factor that determines cancer risk and an understanding of the combinations of interactions (via gene expression and natural selection) between the Barrett's
Yannick H. Derwa, Meng‐Lay Lin, Stuart A. C. McDonald   +2 more
wiley   +1 more source

An Integrative Multi‐Omic Biomarker Panel Distinguishes Hepatocellular Carcinoma From Chronic Liver Disease in HBV‐Predominant Populations

Hepatology Research, EarlyView.
ABSTRACT Aim DNA methylation is a promising diagnostic biomarker for various cancers including hepatocellular carcinoma (HCC). We aimed to identify aberrant DNA methylation and protein alterations via integrated approaches and develop a highly predictive biomarker panel for blood‐based discrimination of HCC from non‐HCC chronic liver disease (CLD) in ...
Hao Zhuang, Xiaopei Hao, Tingting Zhang, Deqiang Li, Guanghao Li, Zhongyi Li, Yuanlin Xu, Shuaiya Ma, Xiangjun Qian, Bo Meng, Xianzhou Zhang, Tiantian Zheng, Feng Han, Hao Wang, Yongmei Li, Nanmu Yang   +15 more
wiley   +1 more source