Results 161 to 170 of about 61,476 (246)

NFE2L2‐mutated urothelial carcinomas frequently show concomitant myxoid and squamous features and have high PD‐L1 expression

Histopathology, EarlyView.
Aims NFE2L2 encodes the transcription factor, NRF2, which is a regulator of cellular oxidative stress responses and metabolic homeostasis. NFE2L2 alterations are implicated in multiple cancers, with significant study in thoracic oncology, with an adverse prognosis, aggressive behaviour, metabolic reprogramming and diminished responses to chemotherapy ...
Dane Wuori, Alexander Guzzetta, Melissa Y. Tjota, Peng Wang, Tatjana Antic, Jung Woo Kwon   +5 more
wiley   +1 more source

Gene-radon interaction effects on lung cancer risk: validation of susceptibility loci using archived DNA from German Uranium miners. [PDF]

Genes Environ
Rosenberger A, Bonzheim I, Fend F, Hochstrat B, Johnen G, Brik A, Rozynek P, Bickeböller H, Mörtl S, Gomolka M.   +9 more
europepmc   +1 more source

Cutaneous lymphomas – an update

Histopathology, EarlyView.
Primary cutaneous lymphomas and lymphoproliferative disorders are defined by integrated clinical, histopathological, immunophenotypic and genetic features as diagnostic criteria also in the 5th edition of the WHO classification of haematolymphoid tumors.
Werner Kempf, Christina Mitteldorf
wiley   +1 more source

Cellular senescence-related gene variants as risk factors for recurrent pregnancy loss. [PDF]

Mol Biol Rep
Nabinger E, Pretto L, Cremonese Filippi-Chiela E, Woycinck Kowalski T, Vieira Sanseverino MT, Sales Luiz Vianna F, Rosa Fraga L.   +6 more
europepmc   +1 more source

Low frequency of MTAP co‐deletion with CDKN2A in peritoneal mesothelioma suggests an independent diagnostic role for MTAP

Histopathology, EarlyView.
Aims Loss of MTAP expression by immunohistochemistry (IHC) is widely used as a surrogate for CDKN2A homozygous deletion (HD) in pleural mesothelioma (PM), but its diagnostic value in peritoneal mesothelioma (PeM) is less well defined. We investigated whether the observed limited reliability of MTAP IHC in PeM reflects a lower frequency of MTAP/CDKN2A ...
Andrea Quaranta, Donato Mancini, Concetta Caporusso, Andrea Marzullo, Luigi Vimercati, Cecilia Salzillo, Federica Pezzuto, Fiorella Calabrese, Gabriella Serio   +8 more
wiley   +1 more source

The detection of MTAP loss in non-small cell lung cancer: a novel biomarker with therapeutic implications. [PDF]

Transl Lung Cancer Res
Choi E, Koorapati G, Kumar PA.
europepmc   +1 more source

Distinct Rb expression pattern in HPV‐associated neuroendocrine carcinomas of the uterine cervix

Histopathology, EarlyView.
Most uterine cervical neuroendocrine carcinoma (UCNEC) cases are HPV‐associated and are characterized by partial loss of Rb, p16 overexpression, and cyclin D1 negativity. A minority of UCNECs exhibit a distinct pattern, characterized by HPV negativity, retained Rb expression, focal p16 expression and cyclin D1 positivity.
Nobuko Yasutake, Misato Komamizu, Takeshi Iwasaki, Ryosuke Kuga, Tomomi Manako, Mikiko Hashisako, Rina Jiromaru, Tomoko Sho, Norihito Yuge, Kenzo Sonoda, Hideaki Yahata, Yoshinao Oda, Hidetaka Yamamoto   +12 more
wiley   +1 more source

Case Report: Acquired CDKN2A/B deletion and mTOR inhibitor resistance in TSC2-mutant metastatic epithelioid angiomyolipoma. [PDF]

Front Med (Lausanne)
He S, Yang J, Yang J, Li C, Shen J, Ye X, Liu Z, Shen W, Zheng J, Wang Y.   +9 more
europepmc   +1 more source

Do alternative classification systems improve prognostication in phyllodes tumours of the breast? A comparative clinicopathological study

Histopathology, EarlyView.
In this cohort, high stromal mitotic activity and malignant heterologous elements best predicted recurrence in breast phyllodes tumours. The WHO 5th Edition showed the strongest correlation with outcomes. Tan et al. showed near‐complete concordance, while the Refined Criteria overclassified malignancy without a clear prognostic refinement.
Yuri Merlotti Gomes, João Pedro dos Reis da Costa, Roberto Bonfim Pimenta Peixoto, João Henrique Quintão, Solange Moraes Sanches, Almir Galvão Vieira Bitencourt, Fabiana Baroni Alves Makdissi, Renato Cagnacci Neto, Guilherme Rocha Melo Gondim, Emílio Marcelo Pereira, Cynthia Aparecida Bueno de Toledo Osório, Helenice Gobbi, Marina De Brot, Rodrigo Fonseca Abreu   +13 more
wiley   +1 more source

Molecular biomarkers as key determinants of outcome in mantle cell lymphoma: results from the FIL V-RBAC trial. [PDF]

Blood Adv
Moia R, Almasri M, Carazzolo ME, Cividini L, Tabanelli V, Melle F, Genuardi E, Cosentino C, Maher N, Bellia M, Mahmoud AM, Evangelista A, Quaglia FM, Fiori S, Bomben R, Tisi MC, Riva M, Merli A, Rotondo F, Corradini P, Farina L, Castellino C, Castellino A, Zilioli VR, Muzi C, Piazza F, Re A, Hohaus S, Rossi FG, Musuraca G, Di Rocco A, Puccini B, Sciarra R, Ballerini F, Cavallo F, Bruna R, Moioli A, Bernardelli A, Patti C, Olivieri J, Bianchi B, Loseto G, Spina M, Usai SV, Stefani PM, Stelitano C, Drandi D, Zinzani P, Ferreri AJM, Balzarotti M, Ladetto M, Ferrero S, Pileri SA, Gaidano G, Visco C.   +54 more
europepmc   +1 more source