Results 181 to 190 of about 61,476 (246)

TNFSF14/LIGHT responses in intestinal and oesophageal fibroblasts are differentially modulated by hydroxylase inhibitors

The Journal of Physiology, EarlyView.
Abstract figure legend LIGHT is a mutual mediator of intestinal and oesophageal fibroblast inflammation with common as well as tissue‐specific effects. Hydroxylase inhibitors can selectively suppress inflammatory factors in both cell types, albeit targeting different signalling pathways.
Cian M. Ohlendieck, Carlos Matellan, Cristina Bauset, Bella Raphael, Mary Nwaezeigwe, Emer Flynn, Kevin Okamoto, Desmond Winter, Colm Collins, Katie Doogan, Seán T. Martin, Glen Doherty, Seema S. Aceves, Mario C. Manresa   +13 more
wiley   +1 more source

<i>CDKN2A</i> mRNA Over-expression Is Associated With CD8+ T Cell Exclusion and IDO1-Mediated Adaptive Immune Resistance in Gastric Adenocarcinoma. [PDF]

Cancer Diagn Progn
Lehrer S, Rheinstein P.
europepmc   +1 more source

Aquaporin‐4 Orchestrates Muscle Cell Differentiation and Satellite Cell Preservation: A Novel Target in Age‐Related Muscle Decline

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 6, December 2026.
ABSTRACT Background Impaired muscle regeneration is a key contributor to age‐related muscle decline, yet the molecular mechanisms linking muscle water homeostasis to regenerative failure remain incompletely understood. Aquaporin‐4 (AQP4), a major skeletal muscle water channel, may have functions beyond water transport that are relevant to muscle ...
María D. Girón, Manuel Manzano, Suzette L. Pereira, Antonio Reinoso, Chiara Burgio, Nora Montero‐Martin, Guillermo Jiménez‐Jiménez, Josep M. Argilés, Ricardo Rueda, José M. López‐Pedrosa, Rafael Salto   +10 more
wiley   +1 more source

The superior prognostic role of pRB1 over p16 immunohistochemistry as a biomarker in meningiomas. [PDF]

Acta Neuropathol Commun
Gött H, Tellermann J, Becker H, Fodi C, Paßlack P, Hoffmann E, Di Francesco ME, Merk DJ, Honegger J, Tabatabai G, Tatagiba M, Behling F, Schittenhelm J.   +12 more
europepmc   +1 more source

Monitoring pharmacodynamic and molecular drug targets in liquid biopsy: Exploratory study in liver cancer with modelling of EGFR Receptor engagement

British Journal of Clinical Pharmacology, Volume 92, Issue 11, Page 3902-3913, November 2026.
Abstract Aim Liquid biopsy is minimally invasive (compared with tissue biopsy) and has previously been used to generate systems data regarding drug elimination via hepatic enzymes and transporters. This study extends quantitative assessment of systems parameters in liquid biopsy to pharmacodynamic (PD) and disease markers relevant to cancer development
Zubida M. Al‐Majdoub, Armin Sepp, Amin Rostami‐Hodjegan, Brahim Achour   +3 more
wiley   +1 more source

Expanding the molecular grading criteria in IDH-mutant astrocytoma. [PDF]

Neuro Oncol
Virata MC, Samanamud J, Slocum CC, Kandoi S, Nguyen P, Savani MR, Shi DD, Sharma S, Hiya S, Maldonado-Díaz C, Clare K, Yokoda RT, Vij M, Mir E, Nishikawa Y, Umphlett M, Yong RL, Bederson JB, Silva-Hurtado TJ, Brem S, Hambardzumyan D, Snuderl M, Viapiano MS, Abdullah KG, McBrayer SK, Hatanpaa KJ, Walker JM, Tsankova NM, Richardson TE.   +28 more
europepmc   +1 more source

Genome Sequencing Outperforms Exome Sequencing in Formalin‐Fixed Paraffin Embedded Tumors Leading to Improved Treatment Options

Cancer Medicine, Volume 15, Issue 11, November 2026.
ABSTRACT Precision oncology is based on comprehensive molecular characterization of a patient's tumor. This is mostly realized by next‐generation sequencing panels or exome sequencing. Data on the value of genome sequencing from formalin‐fixed paraffin embedded (FFPE) material in a clinical setting is still scarce.
Nadja Ballin, Alexander Ott, Michaela Pogoda, Florian Harmuth, Vijay Kumar Ulaganathan, Anton Karelin, Cristiana Roggia, Irina Bonzheim, Stephan Singer, Holly Sundberg‐Malek, Pavlos Missios, Stephan Ossowski, Tobias B. Haack, Olaf Riess, Michael Bitzer, Nisar Malek, Christopher Schroeder, Sorin Armeanu‐Ebinger   +17 more
wiley   +1 more source

Immunohistochemical Loss of MTAP as a Diagnostic and Prognostic Surrogate of <i>CDKN2A/B</i> Homozygous Deletion: A Narrative Review. [PDF]

Diagnostics (Basel)
Salzano S, Caltabiano R, Palicelli A, Zizzo M, Fabozzi M, Koufopoulos N, Boutas I, Cazzato G, Zanelli M, Broggi G.   +9 more
europepmc   +1 more source

Clinicogenomic Features and Outcomes of Adenoid Cystic Carcinoma With Central Nervous System Metastases: A Single‐Institution Cohort Study

Head &Neck, Volume 48, Issue 11, Page 3193-3201, November 2026.
ABSTRACT Background Adenoid cystic carcinoma (ACC) is a rare malignancy with a propensity for perineural invasion and hematogenous spread. Central nervous system (CNS) involvement is uncommon, and detailed clinical and genomic data on this aspect of the disease remain limited.
Omar Elghawy, Jack Stylli, Martin Kurian, Eitan Halper‐Stromberg, Aditi Singh, Christopher D'Avella, Lee Hartner, Roger B. Cohen   +7 more
wiley   +1 more source

What Is Pediatric Melanoma? Clinical and Genomic Features and the Role of Next-Generation Sequencing in Tumor Classification. [PDF]

Int J Dermatol
Sargen MR.
europepmc   +1 more source