Results 201 to 210 of about 61,476 (246)

PRAME Augments K63‐Linked Ubiquitination and Stabilization of METTL3 to Promote Lung Adenocarcinoma Metastasis

MedComm, Volume 7, Issue 11, November 2026.
PRAME promotes lung adenocarcinoma metastasis by inducing K63‐linked ubiquitination of METTL3 at lysine 235, thereby enhancing METTL3 stability and m6A methyltransferase complex assembly. Elevated METTL3 activity increases m6A modification of TGFB2 mRNA, leading to activation of TGF‐β signaling and metastatic progression of lung adenocarcinoma (LUAD ...
Xia Yang, Xuemei Xu, Yaxuan Zhang, Jiamei Guo, Zhiyu Ye, Qiaorui Bai, Xiuqiao Yang, Shujun Liang, Xiang Dong, Xin Zhang, Jiyong Gu, Shuqin Dai, Hongchun Du, Meiwan Chen, Tianyu Tao, Hongyu Guan, Jueheng Wu, Han Tian, Junchao Cai, Mengfeng Li, Xu Li, Yi Yang   +21 more
wiley   +1 more source

The clinical and molecular landscape of thalamic glioma. [PDF]

Neuro Oncol
Zhang L, Wang H, Huang G, Qi X, Carcaboso AM, Wang C, Feng J, Han S, Cheng Z, Ma Z, Yang Y, Xu H, Chen M, Li Y, Zhang X, Cui G, Lyu J, Duan Z, Xu A, Yan C.   +19 more
europepmc   +1 more source

Liquid Biopsy: Past, Present, and Future

MedComm, Volume 7, Issue 11, November 2026.
Liquid biopsy has expanded from cancer genotyping to a broader strategy for probing both oncologic and nononcologic conditions through circulating analytes and multilayer molecular readouts. This review traces the field's past, present, and future—summarizing where liquid biopsy is most actionable today, why performance varies across contexts, and ...
Jiachen Liu, Dianjie Zeng, Keran Zhao, Yuxi Wang, Huijie Hu, Fei Deng, Yinhuai Wang, Liya Sun, Liangmin Fu   +8 more
wiley   +1 more source

High-grade astrocytoma with piloid features: A clinical and genomic analysis of prognostic factors using a large cohort. [PDF]

Neuro Oncol
Zhang S, Singh O, Dazelle K, Quezado M, Cimino PJ, Abdullaev Z, Wu J, Lucas CH, Schreck KC, Holdhoff M, Pytel P, Goodwill V, Macaulay R, McDonald W, Seidman R, Wood M, Bharani K, Neltner J, Richard H, Chang K, Szymanski L, Yip S, Mukherjee A, Lopes Abath Neto O, Sharma SJ, Green R, Brown D, Gubbiotti MA, Ballester LY, Eschbacher J, Smith-Cohn M, Gokden M, Vincentelli C, Yong W, Lee J, Mount C, Fulmer J, Sun M, Ligon K, Santi M, Pai EL, Yeaney G, Alexandrescu S, Raghavan R, Fernandes I, Reis GF, Mandel J, Caccamo D, Rao S, Butt OH, Dahiya S, Stone S, Conway K, Nasrallah MP, Fuller C, Toland A, Lukas RV, Cachia D, Uhlmann EJ, McCord M, Helgager J, Han K, Perry A, Perez S, Daoud E, BeDell D, Highfield H, Kobalka P, Nix JS, Nduom E, Neill S, Gilbert MR, Lakis N, Fonseca A, Shen C, Yoda R, Monterroza L, Cohen AL, Cathcart S, Al Amin M, Campian J, Aldape K.   +81 more
europepmc   +1 more source

Atherosclerosis: From Pathogenesis to Therapeutic Interventions

MedComm, Volume 7, Issue 11, November 2026.
The diagram outlines the core mechanisms driving atherosclerosis, including endothelial dysfunction, inflammatory responses, phenotypic switching of smooth muscle cells, and the gut–vascular axis. It also presents the corresponding therapeutic approaches now under development, such as gene therapies, immunotherapies, and nanotechnology platforms ...
Enge Zhou, Chenxi Zhan, Yuting Li, Yi Zeng, Renfei Luo, Xin Ouyang, Shixing Liu, Renqiang Yang, Nianlong Yan, Long Jiang   +9 more
wiley   +1 more source

Development of an immunocompetent cutaneous squamous cell carcinoma model identifies VISTA and CTLA-4 as targetable immune checkpoints. [PDF]

J Immunother Cancer
Rodriguez Rosario AE, Rangel R, Balbin N, Nizami ZN, Hadi J, Noor A, Dong L, Corona A, Bhavani N, Cruz Sanchez RM, Sunga GM, Veeramachaneni R, Manyam GC, Wang J, Yu W, Sikora AG, N Myers J, Rangel R.   +17 more
europepmc   +1 more source

Gastric Cancer: Epidemiology, Risk Factors, Pathogenesis, Clinical Features, Diagnosis, and Management

MedComm, Volume 7, Issue 11, November 2026.
This comprehensive review summarizes gastric cancer epidemiology, multifactorial risk factors (like infectious, dietary, genetic), pathogenesis such as precancerous evolution, molecular alterations, and a focus on the bidirectional interactions between gastric cancer cells and macrophages in the tumor microenvironment.
Yixuan Xin, Xingya Wang, Yangtao Wu, Qian Liu, Qian Ren, Hui Wang, Jingbo Zhai   +6 more
wiley   +1 more source

Clinicopathologic and FISH-Based Evaluation of CDKN2A/B and EGFR in IDH Mutant Astrocytomas. [PDF]

Noro Psikiyatr Ars
Yıldırım AY, Çetin S, Dolaş İ, Bilgiç B, Ünverengil G.   +4 more
europepmc   +1 more source

Comprehensive genomic profiling of mucosal melanoma reveals novel fusion transcripts and dysregulation of cell‐cycle, MAPK, and PI3K pathways

The Journal of Pathology, Volume 270, Issue 3, Page 380-395, November 2026.
Abstract Mucosal melanomas (MMs) are rare, aggressive cancers with poor outcomes and limited response to standard therapies. A significant knowledge gap exists regarding their genomic landscape and corresponding druggable targets. This study explores this issue through a multi‐omic analysis, including whole exome‐, RNA‐, and targeted sequencing, of ...
Matilde Monti, Martina Brigida Romanello, Luca Agnelli, Matteo Orlandi, Luca Bertoli, Sara Picinoli, Irene Pezzali, Giulio Eugenio Mandelli, Daniela Medicina, Giovanni Ribaudo, Adele Busico, Elena Conca, Vilma Pellegrini, Piera Balzarini, Daniele Gallucci, Anna Di Matteo, Davide Lombardi, Claudia Ghigna, Giancarlo Pruneri, Alessandra Gianoncelli, Marzia Rossato, William Vermi   +21 more
wiley   +1 more source