Results 181 to 190 of about 19,601 (224)

T-cell receptor clonotypic diversity and specialization in digestive system cancers. [PDF]

NPJ Precis Oncol
Li L, Li J, Wang F, Jiang R, Wang H, Li X, Zhen Y.   +6 more
europepmc   +1 more source

VNAR: shark single-domain antibodies for the new era of medical biotechnology. [PDF]

Front Immunol
Olivares-Olivares RA, Bravo AR, Garrido-Soto C, Carvajal JJ, Manubens A, Rivas M, Bustamente C, Retamal-Díaz A, Kalergis AM, Lay MK.   +9 more
europepmc   +1 more source

TCRBinder: Unified pre-trained language model with paired-chain synergy for predicting T-cell receptor binding specificity. [PDF]

PLoS Comput Biol
Dong W, Yang Q, Xu L, Li X, Wang K, Dong S, Luo G, Zhang X, Yang T, Gao X, Wang G.   +10 more
europepmc   +1 more source

Ontogeny of the avian intestinal immunoglobulin repertoire: Modification in CDR3 length and conserved VH-pseudogene usage

Molecular Immunology, 2013
Immunoglobulins play an important role in maintenance of mucosal homeostasis in the gut. The antigen binding specificity of these immunoglobulins depends for a large part on the hypervariable CDR3 region.
Gerco Den Hartog, Richard P M A Crooijmans, Huub F J Savelkoul   +2 more
exaly   +2 more sources

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Measuring CDR3 length variability in individuals during ontogeny

Journal of Immunological Methods, 1994
The portion of the antibody sequence that contributes most to the conformation of the antigen-combining site is the third complementarity-determining region (CDR3). The CDR3 in antibody heavy chains are somatically produced by the rearrangement of three different immunoglobulin (Ig) gene segments, VH, D and JH, and are therefore highly variable in ...
Ellen Hsu
exaly   +3 more sources

Comparison of CDR3 length among thymocyte subpopulations: Impacts of MHC and BV segment on the CDR3 shortening

Molecular Immunology, 2007
Thymocytes are thought to be selected on the basis of antigen specificity between TCR and peptide-MHC (pMHC) ligands. The specificity depends primarily on extensive diversities of complementarity determining region 3 (CDR3), whose specificity is considered to be determined through thymocyte selection.
Takaji, Matsutani, Takehiko, Ohmori, Masaki, Ogata, Hiroyuki, Soga, Shigeru, Kasahara, Takeshi, Yoshioka, Ryuji, Suzuki, Tsunetoshi, Itoh   +7 more
openaire   +2 more sources

Identification of autoimmune encephalomyelitis-associated common CDR3 sequences by CDR3 spectratyping and subsequent DNA hybridization

Journal of Neuroimmunology, 2002
In previous studies, we demonstrated that T cell receptor (TCR) Vbeta8.2 and Vbeta10, both of which are frequently used by encephalitogenic T cells, spectratypes expand oligoclonally in spinal cord lesions of Lewis rats with experimental autoimmune encephalomyelitis (EAE) and that the DSSYEQYF and WDGSGNVLYF sequences are predominantly found in the ...
Youngheun, Jee, Yoh, Matsumoto
openaire   +2 more sources

Backbone Flexibility of CDR3 and Immune Recognition of Antigens

Journal of Molecular Biology, 2014
Conformational entropy is an important component of protein-protein interactions; however, there is no reliable method for computing this parameter. We have developed a statistical measure of residual backbone entropy in folded proteins by using the ϕ-ψ distributions of the 20 amino acids in common secondary structures. The backbone entropy patterns of
Haidar, Jaafar N., Zhu, Wei, Lypowy, Jacqueline, Pierce, Brian G., Bari, Amtul, Persaud, Kris, Luna, Xenia, Snavely, Marshall, Ludwig, Dale, Weng, Zhiping   +9 more
openaire   +3 more sources

Models for antigen receptor gene rearrangement: CDR3 length

Immunology & Cell Biology, 2007
Despite the various processing steps involved in V(D)J recombination, which could potentially introduce many biases in the length distribution of complementarity determining region 3 (CDR3) segments, the observed CDR3 length distributions for complete repertoires are very close to a normal‐like distribution.
Ravit, Saada, Moran, Weinberger, Gitit, Shahaf, Ramit, Mehr   +3 more
openaire   +2 more sources