Results 191 to 200 of about 19,601 (224)

Computational Modeling of Antibody and T-Cell Receptor (CDR3 Loops)

2022
Antibodies and T-cell receptors have been a subject of much interest due to their central role in the immune system and their potential applications in several biotechnological and medical applications from cancer therapy to vaccine development. A unique feature of these two lymphocyte receptors is their ability to bind a huge variety of different ...
Frederikke I, Marin, Paolo, Marcatili
openaire   +2 more sources

CDR3 repertoire diversity of CD8+ T lymphocytes in patients with HCV

Cellular Immunology, 2019
T cell receptors (TCR) diversity is known to serve as a defining hallmark of the antigen-reactive T cell repertoire. Complementarity determining region 3 (CDR3) was the most important region for the recognition of peptide-major histocompatibility complex (MHC) complexes and represented the diversity of TCR repertoire.
Yu, Ping, Mengjia, Song, Meng, Wang, Zhiqin, Li, Yi, Zhang   +4 more
openaire   +2 more sources

The dynamic TRβ/IGH CDR3 repertoire features in patients with liver transplantation

Transplant Immunology, 2023
At present, little is known about the immune mechanism of liver transplantation caused by decompensated cirrhosis. Lymphocytes play an essential important role in the immune rejection of liver transplantation. In this study, we aimed to comprehensively analyze changes in complementary determinant 3 (CDR3) repertoire of T cell receptor β chain (TRβ) and
Junning, Zhang, Zhenyu, Liu, Guangyu, Wang, Xueli, Yang, Weiguo, Sui, Haonan, Guo, Xianliang, Hou   +6 more
openaire   +2 more sources

Assembly of IgH CDR3: Mechanism, Regulation, and Influence on Antibody Diversity

International Reviews of Immunology, 1992
The most variable portion of immunoglobulin molecules is the third complementarity determining region (CDR3) of the heavy chain. This is simply because CDR3 encompasses the region of the rearranged gene where the three gene segments (VH-DH-JH) are joined.
L, VanDyk, K, Meek
openaire   +2 more sources

Structural restriction in the heavy chain CDR3 of human rheumatoid factors

The Journal of Immunology, 1995
Abstract We have compared the variable regions of 14 new IgM rheumatoid factors (RFs), produced in healthy human immunized donors (HIDs) with RFs originating from patients with rheumatoid arthritis (RA) and monoclonal Ig RFs (paraproteins or M-components, MC).
M, Børretzen, I, Randen, J B, Natvig, K M, Thompson   +3 more
openaire   +2 more sources

A shared TCR CDR3 sequence in NOD mouse autoimmune diabetes

International Immunology, 1999
T cells involved in autoimmune diseases have been characterized by the genetic elements used to construct their autoimmune TCR. In the present study, we sequenced the alpha and beta chains of the TCR expressed by a CD4(+) T cell clone, C9, functional in NOD mouse diabetes. Clone C9 can adoptively transfer diabetes or, when attenuated, C9 can be used to
Y, Tikochinski, D, Elias, C, Steeg, H, Marcus, M, Kantorowitz, T, Reshef, V, Ablamunits, I R, Cohen, A, Friedmann   +8 more
openaire   +2 more sources

Standardized analysis for the quantification of Vβ CDR3 T-cell receptor diversity

Journal of Immunological Methods, 2006
Assessment of the diversity of the T-cell receptor (TCR) repertoire is often determined by measuring the frequency and distribution of individually rearranged TCRs in a population of T cells. Spectratyping is a common method used to measure TCR repertoire diversity, which examines genetic variation in the third complementarity-determining region (CDR3)
Long, S Alice, Khalili, Jahan, Ashe, Jimiane, Berenson, Ron, Ferrand, Christophe, Bonyhadi, Mark   +5 more
openaire   +4 more sources

Affinity-matured antibody with a disulfide bond in H-CDR3 loop

Archives of Biochemistry and Biophysics
Affinity maturation increases antigen-binding affinity and specificity of antibodies by somatic hypermutation. Various monoclonal antibodies against (4-hydroxy-3-nitrophenyl)acetyl (NP) were obtained during affinity maturation. Among them, highly matured anti-NP antibodies, such as E11 and E3, possess Cys96H and Cys100H in the complementarity ...
Mutsumi Yoshida, Yuya Hanazono, Nobutaka Numoto, Satoshi Nagao, Saaya Yabuno, Yumi Kitagawa, Hiroshi Sekiguchi, Nobutoshi Ito, Takachika Azuma, Masayuki Oda   +9 more
openaire   +2 more sources

Anti-CDR3 Therapy for B-Cell Malignancies

2013
Abstract : Immunotherapy is rapidly becoming accepted as an effective way to treat human cancer. A large proportion of B-cell malignancies express the product of their rearranged immunoglobulin (IG) genes on the cell surface. Surface-expressed IG constitutes a de facto tumor-specific target antigen.
openaire   +1 more source

Rational design of a peptide analog of the L3T4 CDR3-like region

ImmunoMethods, 1992
The CD4 glycoprotein functions in synergy with the T cell receptor complex to generate the signals involved in T cell activation. The exact role CD4 plays in this process is not fully understood. In an attempt to further define the role of CD4 in T helper activation, we developed a structural model of the mouse CD4 (L3T4) based on the X-ray crystal ...
James M. McDonnell, James M. Varnum, Kevin H. Mayo, Bradford A. Jameson   +3 more
openaire   +1 more source