Results 41 to 50 of about 4,481,323 (329)

3D culture of alginate-hyaluronic acid hydrogel supports the stemness of human mesenchymal stem cells

Scientific Reports
The three-dimensional (3D) cell culture system is being employed more frequently to investigate cell engineering and tissue repair due to its close mimicry of in vivo microenvironments.
Amorn Pangjantuk, Palakorn Kaokaen, Phongsakorn Kunhorm, Nipha Chaicharoenaudomrung, Parinya Noisa   +4 more
doaj   +1 more source

Characterization of the catalytic properties of the membrane-anchored metalloproteinase ADAM9 in cell-based assays.

Biochemical Journal, 2017
ADAM9 (A Disintegrin And Metalloprotease 9) is a membrane-anchored metalloproteinase that has been implicated in pathological retinal neovascularization and in tumor progression.
Thorsten Maretzky, S. Swendeman, Elin Mogollon, G. Weskamp, Umut Şahin, K. Reiss, C. Blobel   +6 more
semanticscholar   +1 more source

Electrochemical microdevice for cell-based assays [PDF]

, 2009
課題番号 ...
スズキ ヒロアキ, 鈴木 博章
core  

Multicentre comparison of a diagnostic assay: Aquaporin-4 antibodies in neuromyelitis optica [PDF]

, 2016
Objective Antibodies to cell surface central nervous system proteins help to diagnose conditions which often respond to immunotherapies. The assessment of antibody assays needs to reflect their clinical utility.
Aktas, O. (Orhan), Altintas, A. (Ayse), Barington, T. (Torben), Berki, T. (Tímea), Berthele, A. (Achim), Bertolotto, A. (Antonio), Comabella, M. (Manuel), Costa, C. (Carme), Deniz, G. (Gunnur), Giometto, B., Granieri, L., Hamann, D. (Dörte), Hartung, H.P., Hintzen, R.Q. (Rogier), Höftberger, R. (Romana), Illes, Z. (Zsolt), Jarius, S. (Sven), Kral, V. (Vlastimil), Leite, M.I. (M. Isabel), Lillevang, S.T. (Søren T.), Marignier, R. (Romain), Montalban, X. (Xavier), Nielsen, H.H. (Helle Hvilsted), Nytrova, P. (Petra), Palace, J. (Jacqueline), Paul, F. (Friedemann), Pelt - Gravesteijn, E.D. (Daniëlle) van, Probst, M. (Monika), Reindl, M. (Markus), Rentzsch, K. (Kristin), Ruiz, A. (Anne), Saiz, A. (Albert Abe), Saschenbrecker, S. (Sandra), Schanda, K. (Kathrin), Siva, A. (Aksel), Sobek, O. (Ondrej), Tintoré, M., Trillenberg, P. (Peter), Tuller, F. (Friederike), Vedeler, C. (Christian), Vincent, A.J.P.E. (Arnoud), Waters, P. (Patrick), Wildemann, B. (Brigitte), Woodhall, M. (Mark), Zuliani, L. (Luigi)   +44 more
core   +1 more source

Leveraging current insights on IL‐10‐producing dendritic cells for developing effective immunotherapeutic approaches

FEBS Letters, EarlyView.
In vivo IL‐10 produced by tissue‐resident tolDC is involved in maintaining/inducing tolerance. Depending on the agent used for ex vivo tolDC generation, cells acquire common features but prime T cells towards anergy, FOXP3+ Tregs, or Tr1 cells according to the levels of IL‐10 produced. Ex vivo‐induced tolDC were administered to patients to re‐establish/
Konstantina Morali, Gloria Giacomello, Michela Vuono, Silvia Gregori   +3 more
wiley   +1 more source

A luminescence-based protocol for assessing fructose metabolism via quantification of ketohexokinase enzymatic activity in mouse or human hepatocytes

STAR Protocols, 2021
Summary: Ketohexokinase (KHK) catalyzes the first step of fructose metabolism. Inhibitors of KHK enzymatic activity are being evaluated in clinical trials for the treatment of non-alcoholic fatty liver disease (NAFLD) and diabetes.
Se-Hyung Park, Robert N. Helsley, Leila Noetzli, Ho-Chou Tu, Kristina Wallenius, Gavin O’Mahony, Jeremie Boucher, Jianming Liu, Samir Softic   +8 more
doaj  

Nanopatterned Extracellular Matrices Enable Cell-Based Assays with a Mass Spectrometric Readout

Nano letters (Print), 2017
Cell-based assays are finding wider use in evaluating compounds in primary screens for drug development, yet it is still challenging to measure enzymatic activities as an end point in a cell-based assay.
Maria D. Cabezas, C. Mirkin, M. Mrksich
semanticscholar   +1 more source

Cell wall composition and biofilm formation of azoles-susceptible and -resistant Candida glabrata strains [PDF]

, 2016
In the present study, three strains of Candida glabrata have been investigated to shed light on the mechanisms involved in azole resistance during adherence and biofilm formation.
Angiolella, Letizia, Castagnola, Massimo, Iavarone, Federica, Leone, Claudia, Marzano, Valeria, Vavala, Elisabetta, Vitali, Alberto   +6 more
core   +5 more sources

FoxO1 signaling in B cell malignancies and its therapeutic targeting

FEBS Letters, EarlyView.
FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac, Petra Pavelkova, Laura Ondrisova, Marek Mraz   +3 more
wiley   +1 more source

Identification of a 3-Alkylpyridinium Compound from the Red Sea Sponge Amphimedon chloros with In Vitro Inhibitory Activity against the West Nile Virus NS3 Protease. [PDF]

, 2018
Viruses are underrepresented as targets in pharmacological screening efforts, given the difficulties of devising suitable cell-based and biochemical assays.
Duggan, Brendan M, Emwas, Abdul-Hamid, Gerwick, William H, Kharbatia, Najeh, Kremb, Stephan, O'Rourke, Aubrie, Raji, Misjudeen, Sioud, Salim, Voolstra, Christian R   +8 more
core   +3 more sources