Results 41 to 50 of about 1,959,228 (334)
Cell-Based Assays for Screening Androgen Receptor Ligands [PDF]
Seminars in Reproductive Medicine, 2015 The androgen receptor (AR, NR3C4) mediates the majority of androgen effects on target cells. The AR is activated following ligand binding that result is enhanced of target gene transcription. Several cell-based model systems have been developed that allow sensitive detection and monitoring of steroids or other compounds with AR bioactivity.
Campana C, PEZZI, Vincenzo, Rainey WE
openaire +3 more sources
Scientific ReportsThe three-dimensional (3D) cell culture system is being employed more frequently to investigate cell engineering and tissue repair due to its close mimicry of in vivo microenvironments.
Amorn Pangjantuk +4 more
doaj +1 more source
Measuring CPT-1-mediated respiration in permeabilized cells and isolated mitochondria
STAR Protocols, 2021 Summary: Carnitine palmitoyltransferase-1 (CPT-1) is a rate-controlling enzyme for long-chain fatty acid oxidation. This manuscript provides protocols for measuring CPT-1-mediated respiration in permeabilized, adherent cell monolayers and mitochondria ...
Krista Yang +3 more
doaj +1 more source
Ceramic materials lead to underestimated DNA quantifications : a method for reliable measurements [PDF]
, 2010 In the context of investigating cell-material interactions or of material-guided generation of tissues, DNA quantification represents an elective method to precisely assess the number of cells attached or embedded within different substrates. Nonetheless,
Martin, I., Piccinini, E., Sadr, N.
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Sickle Cell Disease Is an Inherent Risk for Asthma in a Sibling Comparison Study
Pediatric Blood &Cancer, EarlyView.ABSTRACT Introduction Sickle cell disease (SCD) and asthma share a complex relationship. Although estimates vary, asthma prevalence in children with SCD is believed to be comparable to or higher than the general population. Determining whether SCD confers an increased risk for asthma remains challenging due to overlapping symptoms and the ...
Suhei C. Zuleta De Bernardis +9 more
wiley +1 more source
Time-lapse live-cell imaging of pyroptosis by confocal microscopy
STAR Protocols, 2023 Summary: Pyroptosis is a type of regulated necrosis executed by gasdermin. Osmotic cell swelling and membrane perforation are the key features of pyroptosis.
Shuai Jiang, Kunpeng Qin, Li Sun
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A quantitative approach for measuring the reservoir of latent HIV-1 proviruses. [PDF]
, 2019 A stable latent reservoir for HIV-1 in resting CD4+ T cells is the principal barrier to a cure1-3. Curative strategies that target the reservoir are being tested4,5 and require accurate, scalable reservoir assays.
Antar, Annukka AR +25 more
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Comparison of Short-Term Estrogenicity Tests for Identification of Hormone-Disrupting Chemicals [PDF]
, 1999 The aim of this study was to compare results obtained by eight different short-term assays of estrogenlike actions of chemicals conducted in 10 different laboratories in five countries. Twenty chemicals were selected to represent direct-acting estrogens,
Ana M. Soto +34 more
core +2 more sources
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background While Wilms tumor (WT) typically has a favorable prognosis, relapsed cases—especially those with high‐risk histology—remain therapeutically challenging after intensive frontline therapy. The combination of vincristine and irinotecan has demonstrated activity in pediatric solid tumors, and pazopanib, a multi‐targeted tyrosine kinase ...
Maria Debora De Pasquale +6 more
wiley +1 more source