Results 311 to 320 of about 3,251,205 (352)
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Adipose cell-free DNA in diabetes
Clinica Chimica Acta, 2023Cancer-associated necrosis is a well-known source of cell-free DNA (cfDNA). However, the origins of cfDNA are not strictly limited to cancer. Additionally, dietary exposure induces apoptosis-induced proliferation in adipocytes, leading to the release of cfDNA.
Humardani, Farizky Martriano +2 more
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Application of cell free DNA in ART
Placenta, 2022Various biopsy and sampling methods are used for preimplantation genetic diagnosis (PGD) of embryo. This method benefits blastomer/trophectoderm biopsy to improve the clinical outcome of in vitro fertilization (IVF). However, all of these procedures are invasive and have adverse effects on embryo development.
Amin Alizadegan +10 more
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Med
The analysis of cell-free DNA (cfDNA) has emerged as a cornerstone of minimally invasive liquid biopsies. We summarize the key advancements of the last five years-deepening insights into fundamental cfDNA biology, innovations in wet- and dry-lab approaches, and the amassment of clinical outcome data-and discuss prospects of this field for the coming ...
W H Adrian, Tsui, Y M Dennis, Lo
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The analysis of cell-free DNA (cfDNA) has emerged as a cornerstone of minimally invasive liquid biopsies. We summarize the key advancements of the last five years-deepening insights into fundamental cfDNA biology, innovations in wet- and dry-lab approaches, and the amassment of clinical outcome data-and discuss prospects of this field for the coming ...
W H Adrian, Tsui, Y M Dennis, Lo
openaire +2 more sources
A Cell-free DNA Blood-Based Test for Colorectal Cancer Screening.
New England Journal of MedicineBACKGROUND Colorectal cancer is the third most diagnosed cancer in adults in the United States. Early detection could prevent more than 90% of colorectal cancer-related deaths, yet more than one third of the screening-eligible population is not up to ...
Daniel C. Chung +12 more
semanticscholar +1 more source
2019
Cell-free DNA (cfDNA) found in the plasma or serum is derived from multiple sources, including tumor cells. The fraction of cfDNA derived from tumor cells is termed circulating tumor DNA (ctDNA). Despite the low levels of ctDNA in normal cfDNA, advances in digital polymerase chain reaction (PCR) and next-generation sequencing (NGS) technologies have ...
Hiroyuki Yamamoto +2 more
openaire +1 more source
Cell-free DNA (cfDNA) found in the plasma or serum is derived from multiple sources, including tumor cells. The fraction of cfDNA derived from tumor cells is termed circulating tumor DNA (ctDNA). Despite the low levels of ctDNA in normal cfDNA, advances in digital polymerase chain reaction (PCR) and next-generation sequencing (NGS) technologies have ...
Hiroyuki Yamamoto +2 more
openaire +1 more source
Application of Cell-free DNA Analysis to Cancer Treatment.
New England Journal of Medicine, 2018Emerging Roles of Cell-free Tumor DNA in Oncology The capacity to detect new cancers, treatment-resistant variants, and tumor heterogeneity by noninvasive technology on the basis of tumor DNA in th...
R. Corcoran, B. Chabner
semanticscholar +1 more source
Cell-free DNA Screening for Aneuploidy
Clinical Obstetrics & Gynecology, 2023Cell-free DNA (cfDNA) screening has high detection for the common fetal autosomal aneuploidies, but is not diagnostic. The positive predictive value should be utilized in counseling after a positive cell-free DNA screen, and diagnostic testing should be offered for confirmation.
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Cell-Free DNA in Hematologic Malignancies
JCO Oncology PracticeLiquid biopsy techniques using cell-free DNA (cfDNA) play an increasingly important role in the characterization and surveillance of solid tumors. For blood cancers, molecular response assessment techniques using circulating malignant cells or bone marrow aspirates are well established in clinical care. However, cfDNA has an emerging role in hematology
Joseph G. Schroers-Martin +1 more
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Circulating cell free DNA: Preanalytical considerations
Clinica Chimica Acta, 2013Despite the growing interest in circulating cell-free DNA (ccfDNA) analysis in various clinical fields, especially oncology and prenatal diagnosis, few studies on sample handling have been reported and no analytical consensus is available. The lack of consistency between the various protocols for sample handling and the techniques used for ccfDNA ...
El Messaoudi, Safia +3 more
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The Journal of molecular diagnostics : JMD, 2017
The analysis of cell-free DNA (cfDNA) as a sensitive biomarker for cancer diagnosis and monitoring has resulted in a need for efficient and standardized cfDNA isolation. In this study, we compared the isolation efficiency of the QIAamp circulating nucleic acid kit (QIA) with four other cfDNA isolation kits: the PME free-circulating DNA Extraction Kit ...
Sorber, Laure +6 more
openaire +3 more sources
The analysis of cell-free DNA (cfDNA) as a sensitive biomarker for cancer diagnosis and monitoring has resulted in a need for efficient and standardized cfDNA isolation. In this study, we compared the isolation efficiency of the QIAamp circulating nucleic acid kit (QIA) with four other cfDNA isolation kits: the PME free-circulating DNA Extraction Kit ...
Sorber, Laure +6 more
openaire +3 more sources