Results 21 to 30 of about 371,071 (337)

Cell-penetrating peptides and their analogues as novel nanocarriers for drug delivery [PDF]

BioImpacts, 2015
Introduction: The impermeability of biological membranes is a major obstacle in drug delivery; however, some peptides have transition capabilities of biomembranes.
Samira Jafari, Solmaz Maleki Dizaj, khosro adibkia   +2 more
doaj   +1 more source

Designed Multifunctional Peptides for Intracellular Targets

Antibiotics, 2022
Nature’s way for bioactive peptides is to provide them with several related functions and the ability to cooperate in performing their job. Natural cell-penetrating peptides (CPP), such as penetratins, inspired the design of multifunctional constructs ...
Davor Juretić
doaj   +1 more source

Delivered complementation in planta (DCIP) enables measurement of peptide-mediated protein delivery efficiency in plants

Communications Biology, 2023
Using a fluorescence complementation assay, Delivered Complementation in Planta (DCIP), we demonstrate cell-penetrating peptide-mediated cytosolic delivery of peptides and recombinant proteins in Nicotiana benthamiana.
Jeffrey W. Wang, Henry J. Squire, Natalie S. Goh, Heyuan Michael Ni, Edward Lien, Cerise Wong, Eduardo González-Grandío, Markita P. Landry   +7 more
doaj   +1 more source

Constrained cell penetrating peptides

Drug Discovery Today: Technologies, 2017
In this review we provide an overview of recent developments in the field of cell penetrating peptides (CPPs) on research that aims to achieve better control over their transduction properties - one of the big challenges - by means of restraining them.
S A, Bode, D W P M, Löwik
openaire   +2 more sources

Cell-penetrating peptide sequence and modification dependent uptake and subcellular distribution of green florescent protein in different cell lines

Scientific Reports, 2019
Protein therapy holds great promise for treating a variety of diseases. To act on intracellular targets, therapeutic proteins must cross the plasma membrane.
Sanjay G. Patel, E. Sayers, Lin He, R. Narayan, Thomas L. Williams, Emily M. Mills, R. Allemann, Louis Y. P. Luk, A. Jones, Y. Tsai   +9 more
semanticscholar   +1 more source

Cell Penetration Properties of a Highly Efficient Mini Maurocalcine Peptide

Pharmaceuticals, 2013
Maurocalcine is a highly potent cell-penetrating peptide isolated from the Tunisian scorpion Maurus palmatus. Many cell-penetrating peptide analogues have been derived from the full-length maurocalcine by internal cysteine substitutions and sequence ...
Michel De Waard, Lucie Dardevet, Jean-Marc Sabatier, Céline Tisseyre, Eloi Bahembera, Michel Ronjat   +5 more
doaj   +1 more source

Effect of Synthetic Cell-Penetrating Peptides on TrkA Activity in PC12 Cells

Journal of Pharmacological Sciences, 2008
As TrkA, a high-affinity receptor of nerve growth factor (NGF), is a potential target for relieving uncontrolled inflammatory pain, an effective inhibitor of TrkA has been required for pain management.
Munetaka Hirose, Mayumi Takatori, Yoshihiro Kuroda, Mineo Abe, Eri Murata, Tetsuro Isada, Koyo Ueda, Kenji Shigemi, Masayuki Shibazaki, Fumihiro Shimizu, Masashi Hirata, Keita Fukazawa, Masahiro Sakaguchi, Kyoko Kageyama, Yoshifumi Tanaka   +14 more
doaj   +1 more source

Cyclic Dipeptide Shuttles as a Novel Skin Penetration Enhancement Approach: Preliminary Evaluation with Diclofenac. [PDF]

PLoS ONE, 2016
This study demonstrates the effectiveness of a peptide shuttle in delivering diclofenac into and through human epidermis. Diclofenac was conjugated to a novel phenylalanyl-N-methyl-naphthalenylalanine-derived diketopiperazine (DKP) shuttle and to TAT (a ...
Yousuf Mohammed, Meritxell Teixidó, Sarika Namjoshi, Ernest Giralt, Heather Benson   +4 more
doaj   +1 more source

hnRNPK-derived cell-penetrating peptide inhibits cancer cell survival

Molecular Therapy: Oncolytics, 2021
hnRNPK is a multifunctional protein that plays an important role in cancer cell proliferation and metastasis via its RNA- and DNA-binding properties.
Pavan Kumar Puvvula, Stephanie Buczkowski, Anne M. Moon   +2 more
doaj   +1 more source

Cell-Penetrating Peptides—Mechanisms of Cellular Uptake and Generation of Delivery Systems

Pharmaceuticals, 2010
The successful clinical application of nucleic acid-based therapeutic strategies has been limited by the poor delivery efficiency achieved by existing vectors. The development of alternative delivery systems for improved biological activity is, therefore,
Sara Trabulo, Ana Luísa Cardoso, Miguel Mano, Maria C. Pedroso de Lima   +3 more
doaj   +1 more source