Results 41 to 50 of about 371,071 (337)

Cell-Penetrating Peptide Conjugated SERS Nanosensor for in Situ Intracellular pH Imaging of Single Living Cells during Cell Cycle.

Analytical Chemistry, 2019
Intracellular pH is an important modulator of cell functions, and its subtle change may dramatically affect the cellular activities and cause diseases. A reliable imaging of the intracellular pH is still a great challenge.
Xiao-Shan Zheng, Cheng Zong, Xin Wang, B. Ren   +3 more
semanticscholar   +1 more source

Cell penetrating peptide modified M2 macrophage derived exosomes treat spinal cord injury and rheumatoid arthritis by loading curcumin

Materials & Design, 2023
Effectively suppressing the hyperactivated inflammatory response is a critical strategy for treating inflammatory diseases, such as spinal cord injury (SCI) and rheumatoid arthritis (RA).
Zhuo Li, Yajiang Yuan, Zhongming Zhang, Xiuming Zhang, Hui Yang, Huanan Li, Bao Han, Ziyang Deng, Zipeng Zhou, Xiangyi Fan   +9 more
doaj   +1 more source

Cell-Penetrating Peptide and Transferrin Co-Modified Liposomes for Targeted Therapy of Glioma

Molecules, 2019
Glioma is one of the most aggressive and common malignant brain tumors. Due to the presence of the blood-brain barrier (BBB), the effectiveness of therapeutics is greatly affected. In this work, to develop an efficient anti-glioma drug with targeting and
Xi Wang, Yarong Zhao, Shiyan Dong, Robert J. Lee, Dongsheng Yang, Huan Zhang, Lesheng Teng   +6 more
semanticscholar   +1 more source

Cyclization increases bactericidal activity of arginine-rich cationic cell-penetrating peptide for Neisseria gonorrhoeae. [PDF]

Microbiol Spectr
John CM, Otala SA, Jarvis GA.
europepmc   +2 more sources

Non-metabolic membrane tubulation and permeability induced by bioactive peptides. [PDF]

PLoS ONE, 2007
BACKGROUND:Basic cell-penetrating peptides are potential vectors for therapeutic molecules and display antimicrobial activity. The peptide-membrane contact is the first step of the sequential processes leading to peptide internalization and cell activity.
Antonin Lamazière, Fabienne Burlina, Claude Wolf, Gérard Chassaing, Germain Trugnan, Jesus Ayala-Sanmartin   +5 more
doaj   +1 more source

Cell penetrating peptide functionalized perfluorocarbon nanoemulsions for targeted cell labeling and enhanced fluorine‐19 MRI detection

Magnetic Resonance in Medicine, 2019
A bottleneck in developing cell therapies for cancer is assaying cell biodistribution, persistence, and survival in vivo. Ex vivo cell labeling using perfluorocarbon (PFC) nanoemulsions, paired with 19F MRI detection, is a non‐invasive approach for cell ...
Dina V. Hingorani, Fanny Chapelin, E. Stares, S. Adams, H. Okada, E. Ahrens   +5 more
semanticscholar   +1 more source

Synthesis and Antiproliferative Activities of Conjugates of Paclitaxel and Camptothecin with a Cyclic Cell-Penetrating Peptide

Molecules, 2019
Cell-penetrating peptide [WR]5 has been previously shown to be an efficient molecular transporter for various hydrophilic and hydrophobic molecules. The peptide was synthesized using Fmoc/tBu solid-phase chemistry, and one arginine was replaced with one ...
N. El-Sayed, A. Shirazi, M. Sajid, Shang Eun Park, K. Parang, R. Tiwari   +5 more
semanticscholar   +1 more source

Designing and enhancing the antifungal activity of corneal specific cell penetrating peptide using gelatin hydrogel delivery system

International Journal of Nanomedicine, 2019
Background Fungal keratitis is a major cause of corneal blindness accounting for more than one-third of microbiologically proven cases. The management of fungal keratitis is through topical or systemic antifungal medications alone or in combination with ...
Chatterjee Amit, Shalini Muralikumar, Sargunam Janaki, M. Lakshmipathy, K. Therese, V. Umashankar, P. Padmanabhan, Janakiraman Narayanan   +7 more
semanticscholar   +1 more source

Cell-penetrating peptides enhance peptide vaccine accumulation and persistence in lymph nodes to drive immunogenicity

Proceedings of the National Academy of Sciences of the United States of America, 2022
Significance Current peptide antigen vaccine strategies have shown modest success in eliciting robust T cell priming. We defined mechanisms of action for a promising strategy based on covalently linking peptide antigens to cell-penetrating peptides (CPPs)
Coralie M Backlund, Rebecca L. Holden, K. Moynihan, Daniel Garafola, C. Farquhar, Naveen K Mehta, L. Maiorino, Sydney Pham, J. Iorgulescu, D. Reardon, Catherine J. Wu, B. Pentelute, D. Irvine   +12 more
semanticscholar   +1 more source

Peptide-based delivery of therapeutics in cancer treatment

Materials Today Bio, 2022
Current delivery strategies for cancer therapeutics commonly cause significant systemic side effects due to required high doses of therapeutic, inefficient cellular uptake of drug, and poor cell selectivity.
Timothy Samec, Jessica Boulos, Serena Gilmore, Anthony Hazelton, Angela Alexander-Bryant   +4 more
doaj   +1 more source