Results 21 to 30 of about 1,294,637 (299)

Size-controlled insulin-secreting cell clusters [PDF]

Acta Biomaterialia, 2012
The search for an effective cure for type I diabetes from the transplantation of encapsulated pancreatic β-cell clusters has so far produced sub-optimal clinical outcomes. Previous efforts have not controlled the size of transplanted clusters, a parameter implicated in affecting long-term viability and the secretion of therapeutically sufficient ...
Adam D, Mendelsohn, Crystal, Nyitray, Mark, Sena, Tejal A, Desai   +3 more
openaire   +2 more sources

Machine learning-based cluster analysis of immune cell subtypes and breast cancer survival

Scientific Reports, 2023
Host immunity involves various immune cells working in concert to achieve balanced immune response. Host immunity interacts with tumorigenic process impacting disease outcome. Clusters of different immune cells may reveal unique host immunity in relation
Zhanwei Wang, Dionyssios Katsaros, Junlong Wang, Nicholetta Biglio, Brenda Y. Hernandez, Peiwen Fei, Lingeng Lu, Harvey Risch, Herbert Yu   +8 more
doaj   +1 more source

Exploration the global single-cell ecological landscape of adenomyosis-related cell clusters by single-cell RNA sequencing

Frontiers in Genetics, 2022
Background: Adenomyosis (AM) is a common benign uterine disease that threatens the normal life of patients. Cells associated with microenvironmental immune ecology are crucial in AM, although they are not as well understood at the cellular level.Methods:
Jiajing Lin, Li Liu, Fengque Zheng, Saiqiong Chen, Weiwei Yang, Jingjing Li, Steven Mo, Ding-Yuan Zeng   +7 more
doaj   +1 more source

Semisoft clustering of single-cell data [PDF]

Proceedings of the National Academy of Sciences, 2018
Motivated by the dynamics of development, in which cells of recognizable types, or pure cell types, transition into other types over time, we propose a method of semisoft clustering that can classify both pure and intermediate cell types from data on gene expression from individual cells.
Zhu, Lingxue, Lei, Jing, Klei, Lambertus, Devlin, Bernie, Roeder, Kathryn   +4 more
openaire   +2 more sources

Beta cell count instead of beta cell mass to assess and localize growth in beta cell population following pancreatic duct ligation in mice. [PDF]

PLoS ONE, 2012
BACKGROUND: Pancreatic-tail duct ligation (PDL) in adult rodents has been reported to induce beta cell generation and increase beta cell mass but increases in beta cell number have not been demonstrated.
Marie Chintinne, Geert Stangé, Bart Denys, Zhidong Ling, Peter In 't Veld, Daniel Pipeleers   +5 more
doaj   +1 more source

Collective signal processing in cluster chemotaxis: roles of adaptation, amplification, and co-attraction in collective guidance [PDF]

, 2015
Single eukaryotic cells commonly sense and follow chemical gradients, performing chemotaxis. Recent experiments and theories, however, show that even when single cells do not chemotax, clusters of cells may, if their interactions are regulated by the ...
Camley, Brian A., Levine, Herbert, Rappel, Wouter-Jan, Zimmermann, Juliane   +3 more
core   +3 more sources

Islet-like clusters derived from mesenchymal stem cells in Wharton's Jelly of the human umbilical cord for transplantation to control type 1 diabetes. [PDF]

PLoS ONE, 2008
BACKGROUND: There is a widespread interest in developing renewable sources of islet-replacement tissue for type I diabetes mellitus. Human mesenchymal cells isolated from the Wharton's jelly of the umbilical cord (HUMSCs), which can be easily obtained ...
Kuo Ching Chao, Kuo Fang Chao, Yu Show Fu, Shing Hwa Liu   +3 more
doaj   +1 more source

Signaling clusters in the cell membrane [PDF]

Current Opinion in Cell Biology, 2011
Large-scale molecular assemblies, or signaling clusters, at the cell membrane are emerging as important regulators of cell signaling. Here, we review new findings and describe shared characteristics common to signaling clusters from a diverse set of cellular systems. The well-known T cell receptor cluster serves as our paradigmatic model. Specifically,
Niña C, Hartman, Jay T, Groves
openaire   +2 more sources

Active Flows Cluster Cell Surface Proteins [PDF]

Developmental Cell, 2012
The plasma membrane of cells is a dynamic mixture of different lipids, proteins, and sugars. In a recent issue of Cell, Gowrishankar et al. (2012) propose a model for how the actin cortex may generate and regulate lateral heterogeneity in the plasma membrane by actively clustering cell surface molecules.
openaire   +3 more sources

Nutrient shielding in clusters of cells

Physical Review E, 2013
Cellular nutrient consumption is influenced by both the nutrient uptake kinetics of an individual cell and the cells' spatial arrangement. Large cell clusters or colonies have inhibited growth at the cluster's center due to the shielding of nutrients by the cells closer to the surface.
Lavrentovich, Maxim Olegovich, Koschwanez, John H, Nelson, David   +2 more
openaire   +5 more sources