Results 41 to 50 of about 1,294,637 (299)
Frontiers in Oncology, 2018 The isolation of clusters of circulating tumor cells (CTCs) from cancer patients has recently challenged the accepted view that the initiation of secondary tumors during metastasis involves the dissemination of individual cancer cells.
Alexander N. May +2 more
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Mediators of Inflammation, 2023 Osteosarcoma (OS) is a malignant tumor with an extremely poor prognosis, especially in progressive patients. Immunotherapy based on immune checkpoint inhibitors (ICIs) is considered to be a promising treatment option for OS.
Yu Chen +9 more
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Dynamic L-type CaV1.2 channel trafficking facilitates CaV1.2 clustering and cooperative gating. [PDF]
, 2018 L-type CaV1.2 channels are key regulators of gene expression, cell excitability and muscle contraction. CaV1.2 channels organize in clusters throughout the plasma membrane.
Brust-Mascher, Ingrid +8 more
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The influence of nutrient supply and cell density on the growth and survival of intervertebral disc cells in 3D culture [PDF]
European Cells & Materials, 2011 The adult human intervertebral disc (IVD) is normally avascular. Changes to the extracellular matrix in degenerative disc disease may promote vascularisation and subsequently alter cell nutrition and disc homeostasis. This study examines the influence of
S Stephan, WE Johnson, S Roberts
doaj
Cell-to-cell variation sets a tissue-rheology-dependent bound on collective gradient sensing
, 2017 When a single cell senses a chemical gradient and chemotaxes, stochastic receptor-ligand binding can be a fundamental limit to the cell's accuracy. For clusters of cells responding to gradients, however, there is a critical difference: even genetically ...
Camley, Brian A., Rappel, Wouter-Jan
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Modeling the mechanobioelectricity of cell clusters [PDF]
Biomechanics and Modeling in Mechanobiology, 2020 AbstractWe propose a continuum finite strain theory for the interplay between the bioelectricity and the poromechanics of a cell cluster. Specifically, we refer to a cluster of closely packed cells, whose mechanics is governed by a polymer network of cytoskeletal filaments joined by anchoring junctions, modeled through compressible hyperelasticity. The
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Single-Cell Transcriptional Profiling of Cells Derived From Regenerating Alveolar Ducts
Frontiers in Medicine, 2020 Lung regeneration occurs in a variety of adult mammals after surgical removal of one lung (pneumonectomy). Previous studies of murine post-pneumonectomy lung growth have identified regenerative “hotspots” in subpleural alveolar ducts; however, the cell ...
Alexandra B. Ysasi +14 more
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The neutron star inner crust and symmetry energy
, 2012 The cell structure of clusters in the inner crust of a cold \beta-equilibrium neutron star is studied within a Thomas Fermi approach and compared with other approaches which include shell effects. Relativistic nuclear models are considered.
Constança Providência +3 more
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Cell clusters softening triggers collective cell migration in vivo
Nature Materials, 2022 Abstract Embryogenesis, tissue repair and cancer metastasis rely on collective cell migration. In vitro studies propose that cells are stiffer while migrating in stiff substrates, but softer when plated in compliant surfaces which are typically considered as non-permissive for migration.
Cristian L. Marchant +3 more
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Microwell bag culture for large-scale production of homogeneous islet-like clusters
Scientific Reports, 2022 Pluripotent stem-cell derived cells can be used for type I diabetes treatment, but we require at least 105–106 islet-like clusters per patient. Although thousands of uniform cell clusters can be produced using a conventional microwell plate, numerous ...
Ryo Suenaga +6 more
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