Results 51 to 60 of about 1,294,637 (299)
Geometry shapes evolution of early multicellularity
, 2014 Organisms have increased in complexity through a series of major evolutionary transitions, in which formerly autonomous entities become parts of a novel higher-level entity.
Kerr, Ben +3 more
core +3 more sources
An extracellular steric seeding mechanism for Eph-ephrin signaling platform assembly [PDF]
, 2010 Erythropoetin-producing hepatoma (Eph) receptors are cell-surface protein tyrosine kinases mediating cell-cell communication. Upon activation, they form signaling clusters.
A Radu Aricescu +57 more
core +1 more source
Possible New Strategies for the Treatment of Congenital Hyperinsulinism
Frontiers in Endocrinology, 2020 ObjectiveCongenital hyperinsulinism (CHI) is a rare disease characterized by persistent hypoglycemia as a result of inappropriate insulin secretion, which can lead to irreversible neurological defects in infants.
Jelena Sikimic +10 more
doaj +1 more source
Frontiers in Cell and Developmental Biology, 2021 Background: The tumor microenvironment affects the occurrence and development of cancers, including clear cell renal cell carcinoma (ccRCC). However, how the immune contexture interacts with the cancer phenotype remains unclear.Methods: We identified and
Wenhao Xu +12 more
doaj +1 more source
Fracture of complex metallic alloys: An atomistic study of model systems [PDF]
, 2006 Molecular dynamics simulations of crack propagation are performed for two extreme cases of complex metallic alloys (CMAs): In a model quasicrystal the structure is determined by clusters of atoms, whereas the model C15 Laves phase is a simple periodic ...
Abraham FF +16 more
core +4 more sources
Graph analysis of cell clusters forming vascular networks [PDF]
Royal Society Open Science, 2018 This manuscript describes the experimental observation of vasculogenesis in chick embryos by means of network analysis. The formation of the vascular network was observed in the area opaca of embryos from 40 to 55 h of development.
A. P. Alves +3 more
doaj +1 more source
Ribosomal trafficking is reduced in Schwann cells following induction of myelination. [PDF]
, 2015 Local synthesis of proteins within the Schwann cell periphery is extremely important for efficient process extension and myelination, when cells undergo dramatic changes in polarity and geometry.
Love, James M, Shah, Sameer B
core +2 more sources
Scattering of Cell Clusters in Confinement [PDF]
Biophysical Journal, 2016 Epithelial-to-mesenchymal transition (EMT) enables scattering of cell clusters and disseminates motile cells to distant locations in vivo during embryonic development and cancer metastasis. Both stiffness and topography of the extracellular matrix (ECM) have been shown to influence EMT.
openaire +2 more sources
Cell‐Taxi: Mesenchymal Cells Carry and Transport Clusters of Cancer Cells
Small, 2022 Abstract Cell clusters that collectively migrate from primary tumors appear to be far more potent in forming distant metastases than single cancer cells. A better understanding of the collective cell migration phenomenon and the involvement of various cell types during this process is needed.
Jana Zarubova +6 more
openaire +4 more sources
Single-Cell Transcriptomes Reveal a Complex Cellular Landscape in the Middle Ear and Differential Capacities for Acute Response to Infection. [PDF]
, 2020 Single-cell transcriptomics was used to profile cells of the normal murine middle ear. Clustering analysis of 6770 transcriptomes identified 17 cell clusters corresponding to distinct cell types: five epithelial, three stromal, three lymphocyte, two ...
Draf, Clara +6 more
core