Results 41 to 50 of about 16,339,920 (405)

Cell cycle analysis of a cell proliferation-associated human nuclear antigen defined by the monoclonal antibody Ki-67.

Journal of Immunology, 1984
The monoclonal antibody Ki-67 detects a nuclear antigen that is present only in proliferating cells. The aim of the present investigation was to clarify whether the Ki-67 nuclear antigen is restricted in its expression to certain phases of the cell cycle.
J. Gerdes, H. Lemke, H. Baisch, H. Wacker, U. Schwab, H. Stein   +5 more
semanticscholar   +1 more source

Cell Cycle and Apoptosis

Neoplasia, 2000
In multicellular organisms, cell proliferation and death must be regulated to maintain tissue homeostasis. Many observations suggest that this regulation may be achieved, in part, by coupling the process of cell cycle progression and programmed cell death by using and controlling a shared set of factors.
PUCCI, B., KASTEN, M., GIORDANO, A.
openaire   +6 more sources

Cooperation of the BTB-Zinc finger protein, Abrupt, with cytoskeletal regulators in Drosophila epithelial tumorigenesis

Biology Open, 2015
The deregulation of cell polarity or cytoskeletal regulators is a common occurrence in human epithelial cancers. Moreover, there is accumulating evidence in human epithelial cancer that BTB-ZF genes, such as Bcl6 and ZBTB7A, are oncogenic.
Nezaket Turkel, Marta Portela, Carole Poon, Jason Li, Anthony M. Brumby, Helena E. Richardson   +5 more
doaj   +1 more source

Multiscale modelling of cancer progression and treatment control : the role of intracellular heterogeneities in chemotherapy treatment [PDF]

, 2015
Cancer is a complex, multiscale process involving interactions at intracellular, intercellular and tissue scales that are in turn susceptible to microenvironmental changes.
Chaplain, Mark Andrew Joseph, Powathil, Gibin   +1 more
core   +1 more source

Cell cycle and differentiation [PDF]

Current Opinion in Plant Biology, 2004
The development of multicellular organisms relies on the temporal and spatial control of cell proliferation and cell growth. The relationship between cell-cycle progression and development is complex and characterized by mutual dependencies. On the level of the individual cell, this interrelationship has implications for pattern formation and cell ...
Jakoby, M., Schnittger, A.
openaire   +3 more sources

A novel loss-of-function mutation of the voltage-gated potassium channel Kv10.2 involved in epilepsy and autism

Orphanet Journal of Rare Diseases, 2022
Background Novel developmental mutations associated with disease are a continuous challenge in medicine. Clinical consequences caused by these mutations include neuron and cognitive alterations that can lead to epilepsy or autism spectrum disorders ...
Jesús Galán-Vidal, Paula G. Socuéllamos, María Baena-Nuevo, Lizbeth Contreras, Teresa González, María S. Pérez-Poyato, Carmen Valenzuela, Domingo González-Lamuño, Alberto Gandarillas   +8 more
doaj   +1 more source

Fate specification and tissue-specific cell cycle control of the Caenorhabditis elegans intestine [PDF]

, 2010
Coordination between cell fate specification and cell cycle control in multicellular organisms is essential to regulate cell numbers in tissues and organs during development, and its failure may lead to oncogenesis.
Alexandra Segref, Ashcroft N., Ashcroft N. R., Bao Z., Bei Y., Bischoff M., Boutros R., Boxem M., Busino L., Caroline Clucas, Clucas C., Desai A., Edgar L. G., Fire A., Fraser A. G., Galaktionov K., Goldstein B., Goldstein B., Gregorieff A., Hebeisen M., Iain L. Johnstone, Jin J., Juan Cabello, Kaletta T., Kamath R. S., Kikuchi A., Kipreos E. T., Kipreos E. T., Korswagen H. C., Kostic I., Kristjansdottir K., Lin R., Maduro M. F., Marcos Gonzalez-Gaitan, Nishi Y., Ougolkov A., Pellettieri J., Polakis P., Praitis V., Ralf Schnabel, Rivers D. M., Rocheleau C. E., Rocheleau C. E., Schierenberg E., Schlesinger A., Schnabel R., Shirayama M., Sokal R. R., Sulston J. E., Sulston J. E., Thorpe C. J., Thorpe C. J., Timmons L.   +52 more
core   +2 more sources

Regulation of Cell Cycles

Journal of Investigative Dermatology, 1976
Of the major achievements in cell biology during the last 25 years, none is more important than the understanding of regulation of cell cycles. In 1953 two fundamental observations concerning DNA were made. Watson and Crick suggested that the three-dimensional structure of DNA exists as a double helix with specific base pairings, and Howard and Pelc ...
Elizabeth A. Duell, Donald A. Chambers, John J. Voorhees, Cynthia L. Marcelo   +3 more
openaire   +3 more sources

Monitoring cytosolic H2O2 fluctuations arising from altered plasma membrane gradients or from mitochondrial activity

Nature Communications, 2019
Reliable methods of measuring intracellular H2O2 fluctuations are necessary to advance redox biology. Here the authors design a H2O2 sensor based on the fission yeast peroxiredoxin Tpx1 to sense nanomolar fluctuations of intracellular H2O2 in response to
Mercè Carmona, Laura de Cubas, Eric Bautista, Marta Moral-Blanch, Iria Medraño-Fernández, Roberto Sitia, Susanna Boronat, José Ayté, Elena Hidalgo   +8 more
doaj   +1 more source

Epidermal growth factor-mediated T-cell factor/lymphoid enhancer factor transcriptional activity is essential but not sufficient for cell cycle progression in nontransformed mammary epithelial cells [PDF]

, 2004
Because beta-catenin target genes such as cyclin D1 are involved in cell cycle progression, we examined whether beta-catenin has a more pervasive role in normal cell proliferation, even upon stimulation by non-Wnt ligands.
Asthagiri, Anand R., Graham, Nicholas A.
core   +1 more source