WEE1 kinase inhibition reverses G2/M cell cycle checkpoint activation to sensitize cancer cells to immunotherapy [PDF]
OncoImmunology, 2018 Intrinsic resistance to cytotoxic T-lymphocyte (CTL) killing limits responses to immune activating anti-cancer therapies. Here, we established that activation of the G2/M cell cycle checkpoint results in tumor cell cycle pause and protection from ...
Lillian Sun +9 more
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Genetic aberrations in iPSCs are introduced by a transient G1/S cell cycle checkpoint deficiency [PDF]
Nat Commun, 2020 A number of point mutations have been identified in reprogrammed pluripotent stem cells such as iPSCs and ntESCs. The molecular basis for these mutations has remained elusive however, which is a considerable impediment to their potential medical ...
R. Araki +12 more
semanticscholar +2 more sources
Acetylation of MORC2 by NAT10 regulates cell-cycle checkpoint control and resistance to DNA-damaging chemotherapy and radiotherapy in breast cancer [PDF]
Nucleic Acids Res, 2020 MORC family CW-type zinc finger 2 (MORC2) is an oncogenic chromatin-remodeling enzyme with an emerging role in DNA repair. Here, we report a novel function for MORC2 in cell-cycle checkpoint control through an acetylation-dependent mechanism.
Hong-Yi Liu +7 more
semanticscholar +2 more sources
A cell cycle checkpoint for the endoplasmic reticulum [PDF]
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2020 The generation of new cells is one of the most fundamental aspects of cell biology. Proper regulation of the cell cycle is critical for human health, as underscored by many diseases associated with errors in cell cycle regulation, including both cancer and hereditary diseases.
Niwa M.
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Negative regulator of E2F transcription factors links cell cycle checkpoint and DNA damage repair [PDF]
Proc Natl Acad Sci U S A, 2018 Significance DNA is frequently damaged by both endogenous and exogenous factors. In response to DNA damage, cells activate checkpoints to arrest cell cycle progression, allowing sufficient time for DNA repair.
Lili Wang +4 more
semanticscholar +2 more sources
PEG Induces High Expression of the Cell Cycle Checkpoint Gene WEE1 in Embryogenic Callus of Medicago truncatula: Potential Link between Cell Cycle Checkpoint Regulation and Osmotic Stress [PDF]
Front Plant Sci, 2017 Polyethylene glycol (PEG) can be used to mimic osmotic stress in plant tissue cultures to study mechanisms of tolerance. The aim of this experiment was to investigate the effects of PEG (M.W. 6000) on embryogenic callus of Medicago truncatula.
A. Elmaghrabi +3 more
semanticscholar +2 more sources
TOP2A inhibition and its cellular effects related to cell cycle checkpoint adaptation pathway [PDF]
Scientific ReportsIn this study, we investigate the G2 checkpoint activated by chromosome entanglements, the so-called Decatenation Checkpoint (DC), which can be activated by TOP2A catalytic inhibition.
Maria Arroyo +5 more
doaj +2 more sources
Cell Cycle Checkpoint Kinase and Drug Resistance of Lung Cancer [PDF]
Chinese Journal of Lung Cancer, 2021 Lung cancer is the most commonly diagnosed cancer and the leading cause of cancer death. Although great progress has been made in chemotherapy, radiotherapy and targeted therapy, the emergence of acquired drug resistance hinders the efficacy of clinical ...
Zhiyin KE, Ailing LIANG, Yongjun LIU
doaj +2 more sources
npj Breast Cancer, 2017 Cell cycle: Breast cancer subtypes exhibit distinct checkpoint dysfunctions Unique subtypes of breast cancer display distinctive patterns of genomic instability that affect cell division. Jacquelyn J.
Jacquelyn J. Bower +8 more
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Cell-cycle Checkpoints and Aneuploidy on the Path to Cancer [PDF]
In Vivo, 2018 The cell cycle is a complex sequence of events through which a cell duplicates its contents and divides, and involves many regulatory proteins for proper cellular reproduction, including cyclin proteins and cyclin-dependent kinases, oncogenes and tumor-suppressor genes, and mitotic checkpoint proteins.
Amareshwar T K Singh +1 more
openaire +4 more sources