npj Breast Cancer, 2017 Cell cycle: Breast cancer subtypes exhibit distinct checkpoint dysfunctions Unique subtypes of breast cancer display distinctive patterns of genomic instability that affect cell division. Jacquelyn J.
Jacquelyn J. Bower +8 more
doaj +2 more sources
PEG Induces High Expression of the Cell Cycle Checkpoint Gene WEE1 in Embryogenic Callus of Medicago truncatula: Potential Link between Cell Cycle Checkpoint Regulation and Osmotic Stress [PDF]
Front Plant Sci, 2017 Polyethylene glycol (PEG) can be used to mimic osmotic stress in plant tissue cultures to study mechanisms of tolerance. The aim of this experiment was to investigate the effects of PEG (M.W. 6000) on embryogenic callus of Medicago truncatula.
A. Elmaghrabi +3 more
semanticscholar +2 more sources
A checkpoint-oriented cell cycle simulation model [PDF]
Cell Cycle, 2019 Modeling and in silico simulations are of major conceptual and applicative interest in studying the cell cycle and proliferation in eukaryotic cells. In this paper, we present a cell cycle checkpoint-oriented simulator that uses agent-based simulation modeling to reproduce the dynamics of a cancer cell population in exponential growth.
Bernard, David +6 more
openaire +5 more sources
Mechanism for remodelling of the cell cycle checkpoint protein MAD2 by the ATPase TRIP13 [PDF]
Nature, 2018 C. Alfieri, Leifu Chang, D. Barford
semanticscholar +2 more sources
Cell cycle checkpoint factor p15Ink4b is a novel regulator of osteoclast differentiation [PDF]
Sci RepShunya Tsuji +11 more
openalex +2 more sources
Regulation of Glycolysis by Pdk Functions as a Metabolic Checkpoint for Cell Cycle Quiescence in Hematopoietic Stem Cells [PDF]
Cell Stem Cell, 2013 Keiyo Takubo +12 more
openalex +2 more sources
GRK2-mediated AKT activation controls cell cycle progression and G2 checkpoint in a p53-dependent manner [PDF]
Cell Death DiscoveryCell cycle checkpoints, activated by stressful events, halt the cell cycle progression, and prevent the transmission of damaged DNA. These checkpoints prompt cell repair but also trigger cell death if damage persists.
Verónica Rivas +6 more
doaj +2 more sources
β-TrCP1 facilitates cell cycle checkpoint activation, DNA repair, and cell survival through ablation of β-TrCP2 in response to genotoxic stress [PDF]
J Biol Chem, 2021 Sehbanul Islam +3 more
openalex +2 more sources
DNA damage checkpoint execution and the rules of its disengagement
Frontiers in Cell and Developmental Biology, 2022 Chromosomes are susceptible to damage during their duplication and segregation or when exposed to genotoxic stresses. Left uncorrected, these lesions can result in genomic instability, leading to cells’ diminished fitness, unbridled proliferation or ...
Candice Qiu Xia Yam +4 more
doaj +1 more source
The ATM-E6AP-MASTL axis mediates DNA damage checkpoint recovery
eLife, 2023 Checkpoint activation after DNA damage causes a transient cell cycle arrest by suppressing cyclin-dependent kinases (CDKs). However, it remains largely elusive how cell cycle recovery is initiated after DNA damage.
Yanqiu Li +6 more
doaj +1 more source