Results 21 to 30 of about 775,653 (341)

Checkpoint inhibition of origin firing prevents inappropriate replication outside of S-phase

eLife, 2021
Checkpoints maintain the order of cell cycle events during DNA damage or incomplete replication. How the checkpoint response is tailored to different phases of the cell cycle remains poorly understood.
Mark C Johnson, Geylani Can, Miguel Monteiro Santos, Diana Alexander, Philip Zegerman   +4 more
doaj   +1 more source

Dysregulated G2 phase checkpoint recovery pathway reduces DNA repair efficiency and increases chromosomal instability in a wide range of tumours

Oncogenesis, 2021
Defective DNA repair is being demonstrated to be a useful target in cancer treatment. Currently, defective repair is identified by specific gene mutations, however defective repair is a common feature of cancers without these mutations.
Madushan Fernando, Pascal H. G. Duijf, Martina Proctor, Alexander J. Stevenson, Anna Ehmann, Shivam Vora, Dubravka Skalamera, Mark Adams, Brian Gabrielli   +8 more
doaj   +1 more source

Characterization of nucleolar SUMO isopeptidases unveils a general p53-independent checkpoint of impaired ribosome biogenesis

Nature Communications, 2023
Ribosome biogenesis is a multi-step process, in which a network of trans-acting factors ensures the coordinated assembly of pre-ribosomal particles in order to generate functional ribosomes.
Judith Dönig, Hannah Mende, Jimena Davila Gallesio, Kristina Wagner, Paul Hotz, Kathrin Schunck, Tanja Piller, Soraya Hölper, Sara Uhan, Manuel Kaulich, Matthias Wirth, Ulrich Keller, Georg Tascher, Katherine E. Bohnsack, Stefan Müller   +14 more
doaj   +1 more source

Crosstalk between Plk1, p53, cell cycle, and G2/M DNA damage checkpoint regulation in cancer: computational modeling and analysis

npj Systems Biology and Applications, 2021
Different cancer cell lines can have varying responses to the same perturbations or stressful conditions. Cancer cells that have DNA damage checkpoint-related mutations are often more sensitive to gene perturbations including altered Plk1 and p53 ...
Yongwoon Jung, Pavel Kraikivski, Sajad Shafiekhani, Scott S. Terhune, Ranjan K. Dash   +4 more
doaj   +1 more source

Cell size checkpoint control by the retinoblastoma tumor suppressor pathway. [PDF]

PLoS Genetics, 2006
Size control is essential for all proliferating cells, and is thought to be regulated by checkpoints that couple cell size to cell cycle progression.
Su-Chiung Fang, Chris de los Reyes, James G Umen   +2 more
doaj   +1 more source

Direct monitoring of the strand passage reaction of DNA topoisomerase II triggers checkpoint activation. [PDF]

PLoS Genetics, 2013
By necessity, the ancient activity of type II topoisomerases co-evolved with the double-helical structure of DNA, at least in organisms with circular genomes.
Katherine L Furniss, Hung-Ji Tsai, Jo Ann W Byl, Andrew B Lane, Amit C Vas, Wei-Shan Hsu, Neil Osheroff, Duncan J Clarke   +7 more
doaj   +1 more source

Acceleration or Brakes: Which Is Rational for Cell Cycle-Targeting Neuroblastoma Therapy?

Biomolecules, 2021
Unrestrained proliferation is a common feature of malignant neoplasms. Targeting the cell cycle is a therapeutic strategy to prevent unlimited cell division.
Kiyohiro Ando, Akira Nakagawara
doaj   +1 more source

Elevated levels of the polo kinase Cdc5 override the Mec1/ATR checkpoint in budding yeast by acting at different steps of the signaling pathway. [PDF]

PLoS Genetics, 2010
Checkpoints are surveillance mechanisms that constitute a barrier to oncogenesis by preserving genome integrity. Loss of checkpoint function is an early event in tumorigenesis.
Roberto Antonio Donnianni, Matteo Ferrari, Federico Lazzaro, Michela Clerici, Benjamin Tamilselvan Nachimuthu, Paolo Plevani, Marco Muzi-Falconi, Achille Pellicioli   +7 more
doaj   +1 more source

A mitotic phosphorylation feedback network connects Cdk1, Plk1, 53BP1, and Chk2 to inactivate the G(2)/M DNA damage checkpoint.

PLoS Biology, 2010
DNA damage checkpoints arrest cell cycle progression to facilitate DNA repair. The ability to survive genotoxic insults depends not only on the initiation of cell cycle checkpoints but also on checkpoint maintenance.
Marcel A T M van Vugt, Alexandra K Gardino, Rune Linding, Gerard J Ostheimer, H Christian Reinhardt, Shao-En Ong, Chris S Tan, Hua Miao, Susan M Keezer, Jeijin Li, Tony Pawson, Timothy A Lewis, Steven A Carr, Stephen J Smerdon, Thijn R Brummelkamp, Michael B Yaffe   +15 more
doaj   +1 more source

Novel functions of the phosphatase SHP2 in the DNA replication and damage checkpoints. [PDF]

PLoS ONE, 2012
Replication stress- and DNA damage-induced cell cycle checkpoints are critical for maintaining genome stability. To identify protein phosphatases involved in the activation and maintenance of the checkpoints, we have carried out RNA interference-based ...
Yiu Huen Tsang, Xianxian Han, Wing Yu Man, Nelson Lee, Randy Y C Poon   +4 more
doaj   +1 more source