Mechanism for remodelling of the cell cycle checkpoint protein MAD2 by the ATPase TRIP13 [PDF]
Nature, 2018 C. Alfieri, Leifu Chang, D. Barford
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Expanding roles of cell cycle checkpoint inhibitors in radiation oncology
International Journal of Radiation Biology, 2021 Purpose Radiation-induced activation of cell cycle checkpoints have been of long-standing interest. The WEE1, CHK1 and ATR kinases are key factors in cell cycle checkpoint regulation and are essential for the S and G2 checkpoints.
S. Hauge +5 more
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Targeting cell cycle regulation via the G2-M checkpoint for synthetic lethality in melanoma
Cell Cycle, 2021 Disruption of cell cycle checkpoints has been well established as a hallmark of cancer. In particular, the G1-S transition mediated by the cyclin D-cyclin-dependent kinase 4/6 (CDK4/6) pathway is dysregulated in more than 90% of melanoma cases. Therefore,
Nicholas Barnaba, Jeannine R. LaRocque
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Acceleration or Brakes: Which Is Rational for Cell Cycle-Targeting Neuroblastoma Therapy?
Biomolecules, 2021 Unrestrained proliferation is a common feature of malignant neoplasms. Targeting the cell cycle is a therapeutic strategy to prevent unlimited cell division.
Kiyohiro Ando, Akira Nakagawara
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Elevated levels of the polo kinase Cdc5 override the Mec1/ATR checkpoint in budding yeast by acting at different steps of the signaling pathway. [PDF]
PLoS Genetics, 2010 Checkpoints are surveillance mechanisms that constitute a barrier to oncogenesis by preserving genome integrity. Loss of checkpoint function is an early event in tumorigenesis.
Roberto Antonio Donnianni +7 more
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Definitions, 2020 Cell growth and division proceeds through an ordered set of events called cell cycle, which is divided into four distinct phases namely G1 (the first gap phase), S (DNA synthesis), G2 (the second gap phase), and M (mitosis).
Wenjian Ma
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Novel functions of the phosphatase SHP2 in the DNA replication and damage checkpoints. [PDF]
PLoS ONE, 2012 Replication stress- and DNA damage-induced cell cycle checkpoints are critical for maintaining genome stability. To identify protein phosphatases involved in the activation and maintenance of the checkpoints, we have carried out RNA interference-based ...
Yiu Huen Tsang +4 more
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Centrosome-associated regulators of the G2/M checkpoint as targets for cancer therapy
Molecular Cancer, 2009 In eukaryotic cells, control mechanisms have developed that restrain cell-cycle transitions in response to stress. These regulatory pathways are termed cell-cycle checkpoints.
Broaddus Russell R +5 more
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Phosphorylation of the MBF repressor Yox1p by the DNA replication checkpoint keeps the G1/S cell-cycle transcriptional program active. [PDF]
PLoS ONE, 2011 BACKGROUND:In fission yeast Schizosaccharomyces pombe G1/S cell-cycle regulated transcription depends upon MBF. A negative feedback loop involving Nrm1p and Yox1p bound to MBF leads to transcriptional repression as cells exit G1 phase.
Catia Caetano +2 more
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Cell Cycle Regulation by Checkpoints [PDF]
, 2014 Cell cycle checkpoints are surveillance mechanisms that monitor the order, integrity, and fidelity of the major events of the cell cycle. These include growth to the appropriate cell size, the replication and integrity of the chromosomes, and their accurate segregation at mitosis. Many of these mechanisms are ancient in origin and highly conserved, and
Matthew J. O'Connell, Kevin J Barnum
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