Results 41 to 50 of about 812,761 (308)
Cell cycle: Checkpoint proteins and kinetochores [PDF]
Current Biology, 1997 Vertebrate homologs of yeast spindle assembly checkpoint proteins are localized to kinetochores and may act as a sensor for proper chromosome attachment to the mitotic spindle.
openaire +3 more sources
Journal of Immunotherapy for Cancer, 2018 BackgroundNatural killer (NK) cells recognize and lyse target tumor cells in an MHC-unrestricted fashion and complement antigen- and MHC-restricted killing by T-lymphocytes.
J. Friedman +8 more
semanticscholar +1 more source
A yeast cell cycle pulse generator model shows consistency with multiple oscillatory and checkpoint mutant datasets [PDF]
arXiv, 2023 The regulatory mechanisms driving progression of the yeast cell cycle appears to be comprised of an interacting network of transcription factors (TFs), cyclin-dependent kinases (CDK) and ubiquitin ligases. From a systems perspective the controlling regulatory network must produce robust periodic behavior during proliferative phases, but have the ...
arxiv
EBioMedicine, 2014 The identification of SYK as a molecular target in B-lineage leukemia/lymphoma cells prompted the development of SYK inhibitors as a new class of anti-cancer drug candidates.
Fatih M. Uckun +5 more
doaj +1 more source
The anaphase-promoting complex or cyclosome supports cell survival in response to endoplasmic reticulum stress. [PDF]
PLoS ONE, 2012 The anaphase-promoting complex or cyclosome (APC/C) is a multi-subunit ubiquitin ligase that regulates exit from mitosis and G1 phase of the cell cycle.
Meifan Chen +2 more
doaj +1 more source
The Transcription Factor E4F1 Coordinates CHK1-Dependent Checkpoint and Mitochondrial Functions [PDF]
Cell Reports, Elsevier, 2015, 11 (2), pp.220-233.
\<10.1016/j.celrep.2015.03.024\>, 2015 Recent data support the notion that a group of key transcriptional regulators involved in tumorigenesis, including MYC, p53, E2F1, and BMI1, share an intriguing capacity to simultaneously regulate metabolism and cell cycle. Here, we show that another factor, the multifunctional protein E4F1, directly controls genes involved in mitochondria functions ...
arxiv +1 more source
Cell cycle checkpoint in cancer: a therapeutically targetable double-edged sword
Journal of experimental & clinical cancer research : CR, 2016 Major currently used anticancer therapeutics either directly damage DNA or target and upset basic cell division mechanisms like DNA replication and chromosome segregation.
R. Visconti, R. Della Monica, D. Grieco
semanticscholar +1 more source
Toward a systems-level view of mitotic checkpoints [PDF]
Prog Biophys Mol Biol. 2015 Mar;117(2-3):217-24, 2016 Reproduction and natural selection are the key elements of life. In order to reproduce, the genetic material must be doubled, separated and placed into two new daughter cells, each containing a complete set of chromosomes and organelles. In mitosis, transition from one process to the next is guided by intricate surveillance mechanisms, known as the ...
arxiv +1 more source
CDC5 inhibits the hyperphosphorylation of the checkpoint kinase Rad53, leading to checkpoint adaptation. [PDF]
PLoS Biology, 2010 The Saccharomyces cerevisiae polo-like kinase Cdc5 promotes adaptation to the DNA damage checkpoint, in addition to its numerous roles in mitotic progression.
Genevieve M Vidanes +6 more
doaj +1 more source
Wild-type p53 is a cell cycle checkpoint determinant following irradiation.
Proceedings of the National Academy of Sciences of the United States of America, 1992 Cell cycle checkpoints appear to contribute to an increase in cell survival and a decrease in abnormal heritable genetic changes following exposure to DNA damaging agents.
S. Kuerbitz +3 more
semanticscholar +1 more source