Results 41 to 50 of about 775,653 (341)
The anaphase-promoting complex or cyclosome supports cell survival in response to endoplasmic reticulum stress. [PDF]
PLoS ONE, 2012 The anaphase-promoting complex or cyclosome (APC/C) is a multi-subunit ubiquitin ligase that regulates exit from mitosis and G1 phase of the cell cycle.
Meifan Chen +2 more
doaj +1 more source
Cell Reports, 2020 Summary: Cell-autonomous changes in p53 expression govern the duration and outcome of cell-cycle arrest at the G2 checkpoint for DNA damage. Here, we report that mitogen-activated protein kinase (MAPK) signaling integrates extracellular cues with p53 ...
Siddharth De +3 more
doaj +1 more source
Cell cycle checkpoint in cancer: a therapeutically targetable double-edged sword
Journal of experimental & clinical cancer research : CR, 2016 Major currently used anticancer therapeutics either directly damage DNA or target and upset basic cell division mechanisms like DNA replication and chromosome segregation.
R. Visconti, R. Della Monica, D. Grieco
semanticscholar +1 more source
PLoS ONE, 2011 BackgroundIn fission yeast Schizosaccharomyces pombe G1/S cell-cycle regulated transcription depends upon MBF. A negative feedback loop involving Nrm1p and Yox1p bound to MBF leads to transcriptional repression as cells exit G1 phase. However, activation
Catia Caetano +2 more
doaj +1 more source
Cell Cycle Regulation by Checkpoints [PDF]
, 2014 Cell cycle checkpoints are surveillance mechanisms that monitor the order, integrity, and fidelity of the major events of the cell cycle. These include growth to the appropriate cell size, the replication and integrity of the chromosomes, and their accurate segregation at mitosis. Many of these mechanisms are ancient in origin and highly conserved, and
Kevin J, Barnum, Matthew J, O'Connell
openaire +2 more sources
Intrinsic checkpoint deficiency during cell cycle re-entry from quiescence
bioRxiv, 2019 The authors find that human cells re-entering the cell cycle from quiescence have both an impaired p53-dependent DNA replication origin licensing checkpoint and slow origin licensing.
J. Matson +5 more
semanticscholar +1 more source
bir1 deletion causes malfunction of the spindle assembly checkpoint and apoptosis in yeast
Frontiers in Oncology, 2012 Cell division in yeast is a highly regulated and well studied event. Various checkpoints are placed throughout the cell cycle to ensure faithful segregation of sister chromatids.
Qun eRen +5 more
doaj +1 more source
BMC Cell Biology, 2005 Background Mammalian cells have been reported to have a p53-dependent tetraploidy checkpoint that blocks cell cycle progression in G1 in response to failure of cell division.
Stearns Tim, Wong Connie
doaj +1 more source
Cell cycle checkpoint control [PDF]
Experimental & Molecular Medicine, 1997 Genetic instability is considered to be a major driving force of malignancy of cancer cells, and at least some of cancer-associated genetic instability is known to be caused by defects in the cell cycle checkpoint control. Patients of the cancer-prone genetic disorder ataxia telangiectagia frequently develop malignant lymphoma and their cells are ...
Hiroshi Murakami, Hiroto Okayama
openaire +1 more source
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source