Fluorescent Reporters and Biosensors for Probing the Dynamic Behavior of Protein Kinases
Proteomes, 2015 Probing the dynamic activities of protein kinases in real-time in living cells constitutes a major challenge that requires specific and sensitive tools tailored to meet the particular demands associated with cellular imaging.
Juan A. González-Vera, May C. Morris
doaj +1 more source
Cells, 2022 Psoriasis is a persistent T-cell-supported inflammatory cutaneous disorder, which is defined by a significant expansion of basal cells in the epidermis. Cell cycle and STAT genes that control cell cycle progression and viral infection have been revealed ...
Subhashini Dorai, Daniel Alex Anand
doaj +1 more source
Functional modules in the Arabidopsis core cell cycle binary protein-protein interaction network [PDF]
, 2010 As in other eukaryotes, cell division in plants is highly conserved and regulated by cyclin-dependent kinases (CDKs) that are themselves predominantly regulated at the posttranscriptional level by their association with proteins such as cyclins. Although
Boruc, Joanna +8 more
core +4 more sources
Keratinocyte differentiation-dependent human papillomavirus gene regulation [PDF]
, 2017 Human papillomaviruses (HPVs) cause diseases ranging from benign warts to invasive cancers. HPVs infect epithelial cells and their replication cycle is tightly linked with the differentiation process of the infected keratinocyte.
Graham, Sheila V.
core +1 more source
Dynamic proteomics of human protein level and localization across the cell cycle. [PDF]
PLoS ONE, 2012 Regulation of proteins across the cell cycle is a basic process in cell biology. It has been difficult to study this globally in human cells due to lack of methods to accurately follow protein levels and localizations over time. Estimates based on global
Shlomit Farkash-Amar +8 more
doaj +1 more source
Trithorax group proteins: switching genes on and keeping them active [PDF]
, 2011 Cellular memory is provided by two counteracting groups of chromatin proteins termed Trithorax group (TrxG) and Polycomb group (PcG) proteins. TrxG proteins activate transcription and are perhaps best known because of the involvement of the TrxG protein ...
Cavalli, G. +3 more
core +1 more source
Frontiers in Neuroscience, 2018 Adult neurogenesis (AN) is an ongoing developmental process that generates newborn neurons in the olfactory bulb (OB) and the hippocampus (Hi) throughout life and significantly contributes to brain plasticity.
Saad Omais, Carine Jaafar, Noël Ghanem
doaj +1 more source
Cell cycle: Checkpoint proteins and kinetochores [PDF]
Current Biology, 1997 Vertebrate homologs of yeast spindle assembly checkpoint proteins are localized to kinetochores and may act as a sensor for proper chromosome attachment to the mitotic spindle.
openaire +3 more sources
Cdc53p acts in concert with Cdc4p and Cdc34p to control the G1 to S phase transition and identifies a conserved family of proteins [PDF]
, 1996 Regulation of cell cycle progression occurs in part through the targeted degradation of both activating and inhibitory subunits of the cyclin-dependent kinases. During G1, CDC4, encoding a WD-40 repeat protein, and CDC34, encoding a ubiquitin-conjugating
Adams, Alison E M +7 more
core +3 more sources
The Saccharomyces cerevisiae Mob2p-Cbk1p kinase complex promotes polarized growth and acts with the mitotic exit network to facilitate daughter cell-specific localization of Ace2p transcription factor. [PDF]
, 2002 The Saccharomyces cerevisiae mitotic exit network (MEN) is a conserved signaling network that coordinates events associated with the M to G1 transition. We investigated the function of two S.
Drubin, David G +5 more
core +2 more sources